3.4.21.B41: kallikrein 10
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For detailed information about kallikrein 10, go to the full flat file.
Word Map on EC 3.4.21.B41
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3.4.21.B41
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kallikreins
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ovarian
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breast
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prognostic
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carcinoma
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diagnostics
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methylation-specific
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medicine
- 3.4.21.B41
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kallikreins
- ovarian
- breast
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prognostic
- carcinoma
- diagnostics
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methylation-specific
- medicine
Reaction
proteolytic cleavage of polypeptides =
Synonyms
hK10, human kallikrein 10, K10, kallikrein 10, kallikrein-like protein 1, kallikrein-related peptidase 10, KLK-L1, KLK10, NES1, prostase, S01.246, tissue kallikrein-related peptidase 10
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diagnostics
medicine
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hypermethylated KLK10 is frequent in hepatocellular carcinoma and may be useful as marker for clinical application
diagnostics
KLK10 methylation can be used as a biomarker for non-small cell lung cancer
diagnostics
enzyme KLK10 is significantly associated with other prognostic markers in gastroesophageal junction adenocarcinoma and Barrett esophagus, including depth of invasion, indicating its potential as independent biomarker
diagnostics
KLK10 overexpression correlates with poor prognosis in colorectal cancer, being associated with liver metastases, decreased disease-free, and overall survival. Negative correlation between KLK10 expression and tumor grade, indicating that these two parameters. KLK10 expression, assessed by immunohistochemistry, is an independent indicator of poor prognosis. Assessment of KLK10 can be incorporatedto a multi-molecular prognostic model to achieve better and more accurate assessment of disease prognosis are affected by independent mechanisms
diagnostics
elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a favorable prognosis in advanced high-grade serous ovarian cancer patients
diagnostics
urinary KLK10 is a promising non-invasive biomarker for the inoperability and incurability of gastric cancer
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kallikrein 10 may serve as a biomarker for uterine serous papillary carcinoma
medicine
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high status KLK10 expression is a significant factor for disease-free survival and overall survival of colorectal cancer patients. KLK10 gene expression may be used as a marker of unfavorable prognosis for colorectal cancer