3.4.21.B40: kallikrein 9

This is an abbreviated version!
For detailed information about kallikrein 9, go to the full flat file.

Reaction

proteolytic cleavage of polypeptides, preferential cleavage site at paired basic amino acid residues =

Synonyms

EGF-binding protein, EGF-BP, EGF-BP C, epidermal growth factor urogastrone, epidermal growth factor-binding protein, epidermal growth factor-binding protein type C, GK-9, high molecular weight epidermal growth factor, hk9, HMW-EGF, human tissue kallikrein 9, K9, kallikrein 9, kallikrein-related peptidase 9, KLK-S3, KLK9, mGK-9, mK9, mouse kallikrein 9, S01.307, S3 kallikrein, SEV, submandibular enzymatic vasocontrictor, tissue kallikrein, tissue kallikrein 9

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B40 kallikrein 9

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Results	in table
4	AA Sequence
1	Application
1	CAS Registry Number
4	Cloned(Commentary)
17	Disease/ Diagnostics
9	Inhibitors
1	kcat/KM [mM/s]
2	KM Value [mM]
3	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
14	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
5	Purification (Commentary)
2	Reaction
4	Reaction Type
13	Reference
28	Source Tissue
2	Specific Activity [micromol/min/mg]
27	Substrates and Products (Substrate)
4	Subunits
33	Synonyms
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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Substrates Products on EC 3.4.21.B40 - kallikrein 9

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-aminobenzoyl-TSVIRRVQ-ethylenediamine + H2O

?

Rattus norvegicus

-

-

647361

-

-

?

AAPF-7-amido-4-methylcoumarin + H2O

AAPF + 7-amino-4-methylcoumarin

Homo sapiens

Q9UKQ9

15% activity compared to LLVY-7-amido-4-methylcoumarin

752721

-

-

?

benzyloxycarbonyl-Arg-Val-Arg-Arg-4-methyl-coumaryl-7-amide + H2O

benzyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin

Mus musculus

-

low activity

647359

-

-

?

benzyloxycarbonyl-Gln-Arg-Arg-4-methyl-coumaryl-7-amide + H2O

benzyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin

Mus musculus

-

-

647359

-

-

?

benzyloxycarbonyl-Glu-Lys-Lys-4-methyl-coumaryl-7-amide + H2O

benzyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methylcoumarin

Mus musculus

-

low activity

647359

-

-

?

benzyloxycarbonyl-Leu-Lys-Arg-4-methyl-coumaryl-7-amide + H2O

benzyloxycarbonyl-Leu-Lys-Arg + 7-amino-4-methylcoumarin

Mus musculus

-

-

647359

-

-

?

D-Val-Leu-Arg-NHPhNO2

?

Mus musculus

-

-

668778

-

-

?

gurmarin + H2O

?

Rattus norvegicus

-

-

677927

-

-

?

L-kininogen + H2O

kinin + ?

Mus musculus

-

-

668778

-

-

?

LLVY-7-amido-4-methylcoumarin + H2O

LLVY + 7-amino-4-methylcoumarin

Homo sapiens

Q9UKQ9

preferred substrate

752721

-

-

?

midkine + H2O

?

Homo sapiens

Q9UKQ9

-

752721

-

-

?

Nalpha-benzoyl-L-arginine ethyl ester

?

Mus musculus

-

-

668778

-

-

?

Nalpha-p-Tosyl-L-arginine methyl ester

?

Mus musculus

-

-

668778

-

-

?

o-aminobenzoyl-SVIRRVQ-ethylenediamine + H2O

?

Rattus norvegicus

-

-

647361

-

-

?

o-aminobenzoyl-TSVIRRPQ-ethylenediamine + H2O

?

Rattus norvegicus

-

-

647361

-

-

?

p-toluenesulfonyl-L-arginine methyl ester + H2O

p-toluenesulfonyl-L-arginine + methyl alcohol

Rattus norvegicus

-

-

677927

-

-

?

polypeptide + H2O

peptides

3 entries

pre-[epidermal growth factor] + H2O

epidermal growth factor + ?

Mus musculus

-

-

668778

-

-

?

prorenin 2 + H2O

renin 2 + ?

2 entries

Pyr-Arg-Tyr-Lys-Arg-4-methyl-coumaryl-7-amide + H2O

Pyr-Arg-Tyr-Lys-Arg + 7-amino-4-methylcoumarin

Mus musculus

-

best substrate

647359

-

-

?

tissue kallikrein 10 + H2O

?

Homo sapiens

Q9UKQ9

-

752721

-

-

?

additional information

?

-

4 entries

polypeptide + H2O

peptides

Homo sapiens

Q9UKQ9

-

647358

-

647358

?

polypeptide + H2O

peptides

Mus musculus

-

-

647359

-

647359

?

polypeptide + H2O

peptides

Rattus norvegicus

-

-

647361

-

647361

?

prorenin 2 + H2O

renin 2 + ?

Mus musculus

-

recombinant substrate, enzymatically inactive proform

647359

product is the enzymatically active enzyme form

647359

?

prorenin 2 + H2O

renin 2 + ?

Mus musculus

-

specific for mouse prorenin 2 from submandibular gland

647359

product is the enzymatically active enzyme form

647359

?

additional information

?

-

Homo sapiens

Q9UKQ9

enzyme is regulated by steroid hormones in breast cancer cell line BT-474

647358

-

-

?

additional information

?

-

Homo sapiens

Q9UKQ9

the enzyme has strong preference for tyrosine over phenylalanine at the P1 cleavage position

752721

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme has strong preference for tyrosine over phenylalanine at the P1 cleavage position

752721

-

-

?

additional information

?

-

Rattus norvegicus

-

rK9 is able to accommodate aromatic residues in position P1, and prefer a prolyl and hydrophobic residues in position P2'

677927

-

-

?