3.4.21.B40: kallikrein 9

This is an abbreviated version!
For detailed information about kallikrein 9, go to the full flat file.

Reaction

proteolytic cleavage of polypeptides, preferential cleavage site at paired basic amino acid residues =

Synonyms

EGF-binding protein, EGF-BP, EGF-BP C, epidermal growth factor urogastrone, epidermal growth factor-binding protein, epidermal growth factor-binding protein type C, GK-9, high molecular weight epidermal growth factor, hk9, HMW-EGF, human tissue kallikrein 9, K9, kallikrein 9, kallikrein-related peptidase 9, KLK-S3, KLK9, mGK-9, mK9, mouse kallikrein 9, S01.307, S3 kallikrein, SEV, submandibular enzymatic vasocontrictor, tissue kallikrein, tissue kallikrein 9

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B40 kallikrein 9

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Results	in table
4	AA Sequence
1	Application
1	CAS Registry Number
4	Cloned(Commentary)
17	Disease/ Diagnostics
9	Inhibitors
1	kcat/KM [mM/s]
2	KM Value [mM]
3	Metals/Ions
4	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
14	Organism
3	pH Optimum
1	pH Range
1	Posttranslational Modification
5	Purification (Commentary)
2	Reaction
4	Reaction Type
13	Reference
28	Source Tissue
2	Specific Activity [micromol/min/mg]
27	Substrates and Products (Substrate)
4	Subunits
33	Synonyms
1	Temperature Optimum [°C]
1	Temperature Stability [°C]

Disease

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Disease on EC 3.4.21.B40 - kallikrein 9

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Androgen-Insensitivity Syndrome

Induction of epidermal growth factor by tri-iodo-L-thyronine in the submandibular glands of mice with testicular feminization.

6793565

Carcinogenesis

Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.

30150285

Hypertension

Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.

26469898

Infections

Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection.

8757813

Neoplasms

Epidermal Growth Factor (EGF) Autocrine Activation of Human Platelets Promotes EGF Receptor-Dependent Oral Squamous Cell Carcinoma Invasion, Migration, and Epithelial Mesenchymal Transition.

30150285

Neoplasms

The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.

28455445

Ovarian Neoplasms

Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.

29095848

Tuberculosis

Epidermal growth factor-binding protein in Mycobacterium avium and Mycobacterium tuberculosis: a possible role in the mechanism of infection.

8757813

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