3.4.21.B4: granzyme K

This is an abbreviated version!
For detailed information about granzyme K, go to the full flat file.

Reaction

endopeptidase activity. Cleaves after Lys and Arg =

Synonyms

fragmentin, Gr3, granzyme 3, granzyme K, granzyme tryptase K, GRK, grzK, Gzm K, GzmK, lymphocyte tryptase 2, RNK-Tryp-2, S01.146, tryptase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B4 granzyme K

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Results	in table
3	AA Sequence
1	CAS Registry Number
10	Cloned(Commentary)
1	Crystallization (Commentary)
59	Disease/ Diagnostics
1	Expression
9	General Information
1	General Stability
52	Inhibitors
7	Ki Value [mM]
4	KM Value [mM]
3	Localization
7	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
30	Organism
5	pH Optimum
2	pI Value
1	Posttranslational Modification
4	Protein Variants
9	Purification (Commentary)
1	Reaction
23	Reaction Type
30	Reference
36	Source Tissue
5	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
1	Subunits
33	Synonyms

Inhibitors

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Inhibitors on EC 3.4.21.B4 - granzyme K

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

3,3-diphenylpropanoyl-Pro-(4-AmPhGly)P(OPh)2

Homo sapiens

-

potent inhibitor

652711

3,4-dichloroisocoumarin

2 entries

4-aminobenzamidine

2 entries

Aprotinin

5 entries

benzamidine

4 entries

bikunin

3 entries

-

carbobenzoxy-Thr-(4-AmPhGly)P(OPh)2

Homo sapiens

-

quite specific but weak inhibitor

652711

D-Phe-Pro-Arg-CH2Cl

Rattus norvegicus

-

good inhibitor

652655

diisopropylfluorophosphate

Homo sapiens

-

complete inhibition at 0.1 mM

668782

Glu-Gly-Arg-chloromethyl ketone

2 entries

human blood plasma

Homo sapiens

-

-

651948

-

inter-alpha-inhibitor protein

Homo sapiens

P49863

physiological inhibitor, significantly inhibits catalytic activity in vitro

753550

-

inter-alpha-trypsin inhibitor

Homo sapiens

-

complete inhibition at 66 nM

668782

-

inter-alpha-trypsin inhibitor complex

Homo sapiens

-

physiologic inhibitor

651948

-

Kunitz-type inhibitor aprotinin

Homo sapiens

-

-

651948

-

L-Phe-L-Pro-L-Arg-chloromethyl ketone

Homo sapiens

-

complete inhibition at 0.1 mM

668782

leupeptin

5 entries

N-acetyl-YRFK-chloromethylketone

Homo sapiens

-

-

717935

PefablocSC

3 entries

Phe-Pro-Arg-chloromethyl ketone

3 entries

phenylmethylsulfonyl fluoride

2 entries

Phenylmethylsulfonylfluoride

Homo sapiens

-

2 mM

679100

second carboxy-terminal Kunitz-type domain of bikunin

3 entries

-

Soybean trypsin inhibitor

Homo sapiens

-

50% inhibition at 0.025 mM

650656

-

Tos-Lys-CH2Cl

Homo sapiens

-

complete inhibition at 0.1 mM

668782

Z-LysP(OPh)2

Homo sapiens

-

best inhibitor

652711

Z-Trp-Ch2Cl

Rattus norvegicus

-

moderate inhibitor

652655

Zn2+

Homo sapiens

-

significant reduction of enzyme activity

650656

3,4-dichloroisocoumarin

Homo sapiens

-

complete inactivation at 0.1 mM

650656

3,4-dichloroisocoumarin

Homo sapiens

-

complete inhibition at 0.1 mM

668782

4-aminobenzamidine

Homo sapiens

-

81% inactivation at 5 mM

651259

4-aminobenzamidine

Mus musculus

-

57% inactivation at 5 mM

651259

Aprotinin

Homo sapiens

-

94% inactivation at 0.005 mM

651259

Aprotinin

Homo sapiens

-

93% inactivation at 0.015 mM

651948

Aprotinin

Homo sapiens

-

complete inhibition at 0.015 mM

668782

Aprotinin

Homo sapiens

-

0.015 mM

679100

Aprotinin

Mus musculus

-

89% inactivation at 0.005 mM

651259

benzamidine

Homo sapiens

-

50% inhibition at 27 mM

650656

benzamidine

Homo sapiens

-

55% inactivation at 27 mM

651259

benzamidine

Homo sapiens

-

56% inactivation at 27 mM

651948

benzamidine

Mus musculus

-

57% inactivation at 27 mM

651259

bikunin

Homo sapiens

-

light chain of inter-alpha-trypsin inhibitor

651259

-

bikunin

Homo sapiens

-

subunit of inter-alpha-trypsin inhibitor complex, physiologic inhibitor

651948

-

bikunin

Mus musculus

-

light chain of inter-alpha-trypsin inhibitor

651259

-

Glu-Gly-Arg-chloromethyl ketone

Homo sapiens

-

97% inactivation at 0.1 mM

651259

Glu-Gly-Arg-chloromethyl ketone

Mus musculus

-

52% inactivation at 0.1 mM

651259

leupeptin

Homo sapiens

-

50% inhibition at 0.2 mM

650656

leupeptin

Homo sapiens

-

92% inactivation at 0.2 mM

651259

leupeptin

Homo sapiens

-

22% inactivation at 0.2 mM

651948

leupeptin

Homo sapiens

-

50% inhibition at 0.2 mM

668782

leupeptin

Mus musculus

-

22% inactivation at 0.2 mM

651259

PefablocSC

Homo sapiens

-

44% inactivation at 1 mM

651259

PefablocSC

Homo sapiens

-

94% inactivation at 1 mM

651948

PefablocSC

Mus musculus

-

94% inactivation at 1 mM

651259

Phe-Pro-Arg-chloromethyl ketone

Homo sapiens

-

98% inactivation at 0.1 mM

651259

Phe-Pro-Arg-chloromethyl ketone

Homo sapiens

-

complete inactivation at 0.1 mM

651948

Phe-Pro-Arg-chloromethyl ketone

Mus musculus

-

complete inactivation at 0.1 mM

651259

phenylmethylsulfonyl fluoride

Homo sapiens

-

complete inactivation at 2 mM

650656, 651948

phenylmethylsulfonyl fluoride

Homo sapiens

-

complete inhibition at 2 mM

668782

second carboxy-terminal Kunitz-type domain of bikunin

Homo sapiens

-

-

651259

-

second carboxy-terminal Kunitz-type domain of bikunin

Homo sapiens

-

physiologic inhibitor

651948

-

second carboxy-terminal Kunitz-type domain of bikunin

Mus musculus

-

-

651259

-