3.4.21.B34: tricorn core protease (archaea)

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For detailed information about tricorn core protease (archaea), go to the full flat file.

Reaction

Synonyms

TLP, TRI, Tri-ScC77, Tricorn protease homolog 1, trilobed protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.B34 tricorn core protease (archaea)

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Results	in table
1	Activating Compound
3	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
5	Crystallization (Commentary)
10	Inhibitors
1	Localization
4	Metals/Ions
5	Molecular Weight [Da]
10	Organism
2	pH Optimum
1	pI Value
3	Protein Variants
4	Purification (Commentary)
10	Reference
23	Substrates and Products (Substrate)
5	Subunits
5	Synonyms
2	Temperature Optimum [°C]

Engineering

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Engineering on EC 3.4.21.B34 - tricorn core protease (archaea)

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Go to Protein Variants Search

L184C

Thermoplasma acidophilum

P96086

increase in activity with benzoyl-Val-Gly-Arg-7-amido-4-methylcoumarin and insulin B chain to more than 150% of the wild-type activity, no activity with casein

652897

R131E/R132E

Thermoplasma acidophilum

P96086

slight decrease in activity with benzoyl-Val-Gly-Arg-7-amido-4-methylcoumarin, strong decrease in activity with insulin B chain, barely detectable activity with casein

652897

R414C/A643C

Thermoplasma acidophilum

P96086

decrease in activity with benzoyl-Val-Gly-Arg-7-amido-4-methylcoumarin to 70% of wild-type activity, decrease in activity with insulin B chain as substrate to 50% of wild-type activity, no activity with casein

652897