3.4.21.B3: duodenase
This is an abbreviated version!
For detailed information about duodenase, go to the full flat file.
Word Map on EC 3.4.21.B3
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3.4.21.B3
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duodenal
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mucosa
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cathepsins
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mast
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soybean
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brunner
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granzymes
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chymases
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par1
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enteropeptidase
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antichymotrypsin
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zymogen
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janus-faced
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chymotrypsinogen
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beta-hexosaminidase
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degranulation
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biotechnology
-
analysis
- 3.4.21.B3
- duodenal
- mucosa
- cathepsins
-
mast
- soybean
-
brunner
-
granzymes
- chymases
- par1
- enteropeptidase
- antichymotrypsin
- zymogen
-
janus-faced
- chymotrypsinogen
- beta-hexosaminidase
-
degranulation
- biotechnology
- analysis
Reaction
proteolytic cleavage of polypeptides to large and stable peptides, preferential cleavage sites: Lys-, Arg-, Tyr-, Phe-, Leu-, -Pro =
Synonyms
ChlD, chymotrypsin-like duodenase, DSD, dual-specificity duodenase, duodenase, duodenase I, duodenase serine protease, duodenase-like protein, granzyme-like protein III
ECTree
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Substrates Products
Substrates Products on EC 3.4.21.B3 - duodenase
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REACTION DIAGRAM
alpha-N-acetyl-Leu-Leu-Arg-4-nitroanilide + H2O
alpha-N-acetyl-Leu-Leu-Arg + 4-nitroaniline
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-
-
?
alpha-N-acetyl-Leu-Lys-Arg-4-nitroanilide + H2O
alpha-N-acetyl-Leu-Lys + Arg + 4-nitroaniline
-
-
-
?
alpha-N-benzoyl-Val-Gly-Arg-4-nitroanilide + H2O
alpha-N-benzoyl-Val-Gly-Arg + 4-nitroaniline
-
-
-
?
alpha-N-benzyloxycarbonyl-Ala-Ala-Ala-Arg-4-nitroanilide + H2O
alpha-N-benzyloxycarbonyl-Ala-Ala-Ala-Arg + 4-nitroaniline
-
-
-
?
alpha-N-benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg-4-nitroanilide + H2O
alpha-N-benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg + 4-nitroaniline
-
-
-
?
alpha-N-succinyl-Ala-Ala-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Phe + 4-nitroaniline
alpha-N-succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Pro-Leu + 4-nitroaniline
-
-
-
?
alpha-N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
alpha-N-succinyl-Gly-Gly-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Gly-Gly-Phe + 4-nitroaniline
-
-
-
?
alpha-N-succinyl-Ser-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Ser-Pro-Lys + 4-nitroaniline
-
-
-
?
alpha-N-succinyl-Ser-Thr-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Ser-Thr-Pro-Lys + 4-nitroaniline
-
-
-
?
alpha-N-succinyl-Thr-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Thr-Pro-Lys + 4-nitroaniline
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-
-
?
alpha-N-succinyl-Val-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline
alpha-N-t-butoxycarbonyl-Gly-Phe-Arg-4-nitroanilide + H2O
N-t-butoxycarbonyl-Gly-Phe-Arg + 4-nitroaniline
-
-
-
?
angiotensin II + H2O
fragments of angiotensin II
enzyme cleaves bond between residues 2-3 and 4-5
-
-
?
bovine duodenase + H2O
fragments of bovine duodenase
enzyme cleaves bond between residues 14-15, 17-18, 63-64, 70-71, 110-111, 138-139, 157-158, 162-163, 174-175 and 197-198
-
-
?
bovine proenteropeptidase + H2O
enteropeptidase fragments
inactive protease substrate from bovine duodenal mucosa, recombinant 150 kDa glycoprotein
activated protease, cleaved into 2 fragments corresponding to heavy and light chain of the enteropeptidase, 130-140 kDa and 43 kDa
-
?
Escherichia coli La-protease + H2O
fragments of Escherichia coli La-protease
enzyme cleaves bond between residues 219-220 and 239-240
-
-
?
human gamma-interferon + H2O
fragments of human gamma-interferon
enzyme cleaves bond between residues 69-70
-
-
?
human interleukin II-(59-79) + H2O
fragments of human interleukin II-(59-79)
enzyme cleaves bond between residues 66-67
-
-
?
human proinsulin + H2O
fragments of human proinsulin
cleaved bonds, overview
-
-
?
N-succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
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-
-
-
?
Naja naja oxiana neurotoxin II + H2O
fragments of Naja naja oxiana neurotoxin II
enzyme cleaves bond between residues 15-16, 26-27, 44-45, and 32-33
-
-
?
surfagon + H2O
fragments of surfagon
enzyme cleaves bond between residues 3-4
-
-
?
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
tosyl-Gly-Pro-Arg + p-nitroaniline
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-
-
-
?
tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
tosyl-Gly-Pro-Lys + p-nitroaniline
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-
-
?
alpha-N-succinyl-Ala-Ala-Phe + 4-nitroaniline
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-
-
?
alpha-N-succinyl-Ala-Ala-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Phe + 4-nitroaniline
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-
-
-
?
alpha-N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
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-
-
?
alpha-N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline
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-
-
?
alpha-N-succinyl-Val-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline
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-
-
-
?
alpha-N-succinyl-Val-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline
-
-
-
?
alpha-N-tosyl-Gly-Pro-Lys + 4-nitroaniline
-
-
-
?
alpha-N-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
alpha-N-tosyl-Gly-Pro-Lys + 4-nitroaniline
-
-
-
-
?
angiotensinogen-(1-14) + H2O
fragments of angiotensinogen-(1-14)
enzyme cleaves bond between residues 8-9
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-
?
fragments of bovine serum albumin
enzyme cleaves bond between residues 27-28, 41-42, 64-65, 210-211, 223-224, 231-232, 238-239, and 409-410
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-
?
bovine serum albumin + H2O
fragments of bovine serum albumin
enzyme cleaves the bonds Phe26-Ser27, Lys40-Leu41, Lys63-Ser64, Lys209-Ala210, Lys230-Leu231, Lys237-Val238, and Tyr409-Thr410
-
-
?
glucagon + H2O
fragments of glucagon
enzyme cleaves bond between residues 12-13 and 18-19
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-
?
glucagon + H2O
fragments of glucagon
enzyme cleaves the bonds Lys12-Arg13 and Arg18-Ala19
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-
?
melittin + H2O
fragments of melittin
enzyme cleaves bond between residues 6-7, 7-8, 9-10, and 22-23
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-
?
melittin + H2O
fragments of melittin
leaved sites, specificity, overview
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-
?
polypeptide + H2O
peptides
enzyme belongs to the serine protease subfamily
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-
?
polypeptide + H2O
peptides
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enzyme belongs to the serine protease subfamily
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-
?
polypeptide + H2O
peptides
enzyme belongs to the serine protease subfamily
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-
?
polypeptide + H2O
peptides
enzyme shows very broad substrate specificity due to absence of the SH-bridge at residues 191 and 220, chymotrypsinogen numbering, with retention of normal catalytic activity compared to other serine proteases, similar to granzyme-like proteases
-
-
?
polypeptide + H2O
peptides
enzyme belongs to the serine protease subfamily
-
-
?
fragments of porcine proinsulin
enzyme cleaves bond between residues 29-30, 31-32, 32-33, 56-57, 64-65 and 66-67
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-
?
porcine proinsulin + H2O
fragments of porcine proinsulin
enzyme cleaves the bonds Lys-29-Thr30, Arg31-Arg32, Arg32-Glu33, Leu56-Ala57, Lys64-Arg65, and Arg66-Gly67
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-
?