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3.4.21.B3: duodenase

This is an abbreviated version!
For detailed information about duodenase, go to the full flat file.

Word Map on EC 3.4.21.B3

Reaction

proteolytic cleavage of polypeptides to large and stable peptides, preferential cleavage sites: Lys-, Arg-, Tyr-, Phe-, Leu-, -Pro =

Synonyms

ChlD, chymotrypsin-like duodenase, DSD, dual-specificity duodenase, duodenase, duodenase I, duodenase serine protease, duodenase-like protein, granzyme-like protein III

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B3 duodenase

Substrates Products

Substrates Products on EC 3.4.21.B3 - duodenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-N-acetyl-Leu-Leu-Arg-4-nitroanilide + H2O
alpha-N-acetyl-Leu-Leu-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-acetyl-Leu-Lys-Arg-4-nitroanilide + H2O
alpha-N-acetyl-Leu-Lys + Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-benzoyl-Val-Gly-Arg-4-nitroanilide + H2O
alpha-N-benzoyl-Val-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-benzyloxycarbonyl-Ala-Ala-Ala-Arg-4-nitroanilide + H2O
alpha-N-benzyloxycarbonyl-Ala-Ala-Ala-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg-4-nitroanilide + H2O
alpha-N-benzyloxycarbonyl-Ala-Ala-Ile-Arg-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Ala-Ala-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Phe + 4-nitroaniline
show the reaction diagram
alpha-N-succinyl-Ala-Ala-Pro-Leu-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Pro-Leu + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
alpha-N-succinyl-Gly-Gly-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Gly-Gly-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Ser-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Ser-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Ser-Thr-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Ser-Thr-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Thr-Pro-Lys-4-nitroanilide + H2O
alpha-N-succinyl-Thr-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-succinyl-Val-Pro-Phe-4-nitroanilide + H2O
alpha-N-succinyl-Val-Pro-Phe + 4-nitroaniline
show the reaction diagram
alpha-N-t-butoxycarbonyl-Gly-Phe-Arg-4-nitroanilide + H2O
N-t-butoxycarbonyl-Gly-Phe-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
alpha-N-tosyl-Gly-Pro-Lys-4-nitroanilide + H2O
alpha-N-tosyl-Gly-Pro-Lys + 4-nitroaniline
show the reaction diagram
angiotensin II + H2O
fragments of angiotensin II
show the reaction diagram
enzyme cleaves bond between residues 2-3 and 4-5
-
-
?
angiotensinogen-(1-14) + H2O
fragments of angiotensinogen-(1-14)
show the reaction diagram
bovine duodenase + H2O
fragments of bovine duodenase
show the reaction diagram
enzyme cleaves bond between residues 14-15, 17-18, 63-64, 70-71, 110-111, 138-139, 157-158, 162-163, 174-175 and 197-198
-
-
?
bovine proenteropeptidase + H2O
enteropeptidase fragments
show the reaction diagram
inactive protease substrate from bovine duodenal mucosa, recombinant 150 kDa glycoprotein
activated protease, cleaved into 2 fragments corresponding to heavy and light chain of the enteropeptidase, 130-140 kDa and 43 kDa
-
?
Bovine serum albumin + H2O
?
show the reaction diagram
-
-
-
-
?
bovine serum albumin + H2O
fragments of bovine serum albumin
show the reaction diagram
Escherichia coli La-protease + H2O
fragments of Escherichia coli La-protease
show the reaction diagram
enzyme cleaves bond between residues 219-220 and 239-240
-
-
?
FMRF-NH2 + H2O
?
show the reaction diagram
-
-
-
?
glucagon + H2O
fragments of glucagon
show the reaction diagram
human gamma-interferon + H2O
fragments of human gamma-interferon
show the reaction diagram
enzyme cleaves bond between residues 69-70
-
-
?
human interleukin II-(59-79) + H2O
fragments of human interleukin II-(59-79)
show the reaction diagram
enzyme cleaves bond between residues 66-67
-
-
?
human proinsulin + H2O
fragments of human proinsulin
show the reaction diagram
cleaved bonds, overview
-
-
?
LEEELKPLEEVLNL + H2O
LEEELKPL + EEVLNL
show the reaction diagram
-
-
-
?
LVTQEVSPKIVGGS + H2O
LVTQEVSPK + IVGGS
show the reaction diagram
-
-
-
?
melittin + H2O
fragments of melittin
show the reaction diagram
N-succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-succinyl-Thr-Pro-Lys-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
Naja naja oxiana neurotoxin II + H2O
fragments of Naja naja oxiana neurotoxin II
show the reaction diagram
enzyme cleaves bond between residues 15-16, 26-27, 44-45, and 32-33
-
-
?
polypeptide + H2O
peptides
show the reaction diagram
porcine proinsulin + H2O
fragments of porcine proinsulin
show the reaction diagram
protease-activated receptor-1 + H2O
?
show the reaction diagram
-
-
-
?
surfagon + H2O
fragments of surfagon
show the reaction diagram
enzyme cleaves bond between residues 3-4
-
-
?
tosyl-Gly-Pro-Arg-p-nitroanilide + H2O
tosyl-Gly-Pro-Arg + p-nitroaniline
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
tosyl-Gly-Pro-Lys-p-nitroanilide + H2O
tosyl-Gly-Pro-Lys + p-nitroaniline
show the reaction diagram
-
-
-
?