3.4.21.B21: trepolisin

This is an abbreviated version!
For detailed information about trepolisin, go to the full flat file.

Reaction

chymotrypsin-like protease, cleaves peptide bonds containing phenylalanine and proline =

Synonyms

chymotrypsin-like protease, chymotrypsin-like proteinase, CTLP, dentilisin, PrtP, PrtP protease, S08.024, Td chymotrypsin-like protease, Td-CTLP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B21 trepolisin

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Results	in table
2	Activating Compound
2	AA Sequence
4	Application
1	CAS Registry Number
5	Cloned(Commentary)
1	Expression
19	General Information
15	Inhibitors
8	Localization
1	Metals/Ions
12	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
33	Organism
5	pH Optimum
1	pI Value
11	Protein Variants
3	Purification (Commentary)
1	Reaction
6	Reaction Type
21	Reference
1	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
51	Substrates and Products (Substrate)
2	Subunits
36	Synonyms
3	Temperature Optimum [°C]
1	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 3.4.21.B21 - trepolisin

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

4-mercuribenzenesulfonic acid

Treponema denticola

-

98% inhibition at 0.01 mM

651473

Bowman-Birk soybean trypsin-chymotrypsin inhibitor

Treponema denticola

-

-

673907

-

DFP

Treponema denticola

-

inactivates

673907

diethyl dicarbonate

Treponema denticola

-

inactivates

673907

diisopropyl fluorophosphates

Treponema denticola

-

97% inhibition at 1 mM

651473

EDTA

Treponema denticola

-

41% inhibition at 5 mM

651473

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

Treponema denticola

-

inactivates

673907

PMSF

3 entries

Soybean trypsin inhibitor

Treponema denticola

-

49% inhibition at 0.01 mM

651473

-

thiol-blocking reagent

Treponema denticola

-

-

673907

-

Tos-Phe-CH2Cl

Treponema denticola

-

-

673907

ZnCl2

Treponema denticola

-

46% inhibition at 1 mM

651473

additional information

Treponema denticola

-

not inhibited by Tos-Lys-CH2Cl, alpha1-proteinase inhibitor and pepstatin

673907

-

PMSF

Treponema denticola

-

-

673907

PMSF

Treponema denticola

P96091

the inhibitor treatment leads to inactivation of the enzymes proteolytic activity, but has no effect on adherence of Treponema denticola to Porphyromonas gingivalis and Tannerella forsythia; the inhibitor treatment leads to inactivation of the enzymes proteolytic activity, but has no effect on adherence of Treponema denticola to Porphyromonas gingivalis and Tannerella forsythia

731118

PMSF

Treponema denticola

-

the inhibitor treatment leads to over 95% inactivation of the enzymes proteolytic activity, but has no effect on adherence of Treponema denticola to the biofilm and Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, and Parvimonas micra

732466