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0.96
2-Naph-3Pya-Lys-Arg-p-nitroanilide
-
-
0.32
2-Naph-Cit-Lys-Arg-p-nitroanilide
-
-
0.57
2-Naph-Cit-Orn-Arg-p-nitroanilide
-
-
0.11
2-Naph-hArg-Lys-Arg-p-nitroanilide
-
-
0.3
2-Naph-Lys-AcLys-Arg-p-nitroanilide
-
-
0.89
2-Naph-Lys-Arg-Arg-p-nitroanilide
-
-
0.43
2-Naph-Lys-Cit-Arg-p-nitroanilide
-
-
0.59
2-Naph-Lys-hArg-Arg-p-nitroanilide
-
-
0.0431 - 1.08
2-Naph-Lys-Lys-Arg-p-nitroanilide
1.58
2-Naph-Lys-Orn-Arg-p-nitroanilide
-
-
0.98
2-Naph-Orn-Lys-Arg-p-nitroanilide
-
-
0.27
2-Naph-Orn-Orn-Arg-p-nitroanilide
-
-
0.006 - 0.15
7-methoxycoumarin-4-acetyl-DEMEECASHLPYK-(epsilon-NHCOCH3)
0.227
7-methoxycoumarin-4-acetyl-EDASTPCSGSN-(4-nitro)Phe
-
presence of inhibitor peptide 4Apep21-34KK
0.00833
9-fluorenylmethyloxycarbonyl-YQEFDEMEECASHLPYIEQG
-
-
1.6
Ac-Aib-Lys-Lys-Arg-p-nitroanilide
-
-
2.51
Ac-Aoc-Lys-Lys-Arg-p-nitroanilide
-
-
0.6 - 7.2
Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-AbuPSI[COO]-Ala-Ser-Lys(QSY-7)-amide
2.28
Ac-Cha-Lys-Lys-Arg-p-nitroanilide
-
-
1.78
Ac-Chg-Lys-Lys-Arg-p-nitroanilide
-
-
0.00167 - 0.03
Ac-DEEMECASHLPYK-NH2
1.3
Ac-DPNRKR-4-nitroanilide
-
37°C, pH 9.5
0.033 - 0.58
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
1.9
Ac-FASGKR-4-nitroanilide
-
37°C, pH 9.5
0.011 - 6.08
Ac-KPGLKR-4-nitroanilide
0.2 - 1
Ac-L-Asp-L-Glu-L-Asp-(EDANS)-L-Glu-L-Glu-alpha-aminobutyric acid-PSI[COO]-L-Ala-L-Ser-L-Lys-(DABCYL)-NH2
0.5
Ac-Leu-3Pya-Lys-Arg-p-nitroanilide
-
-
0.9
Ac-Leu-4Pya-Lys-Arg-p-nitroanilide
-
-
0.75
Ac-Leu-aPhe-Lys-Arg-p-nitroanilide
-
-
1.44
Ac-Leu-Cit-Lys-Arg-p-nitroanilide
-
-
0.018 - 0.314
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
118
Ac-Leu-hArg-Lys-Arg-p-nitroanilide
-
-
0.036 - 1.64
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
0.72
Ac-Leu-nPhe-Lys-Arg-p-nitroanilide
-
-
1.79
Ac-Leu-Orn-Lys-Arg-p-nitroanilide
-
-
1.1
Ac-LQYTKR-4-nitroanilide
-
37°C, pH 9.5
2.35
Ac-Nle-Lys-Lys-Arg-p-nitroanilide
-
-
2.36
Ac-Nva-Lys-Lys-Arg-p-nitroanilide
-
-
1.74
Ac-Tbg-Lys-Lys-Arg-p-nitroanilide
-
-
0.005
Ac-YQEFDEMEECAS
-
-
0.00333
Ac-YQEFDEMEECASH
-
-
0.00667
Ac-YQEFDEMEECASHL
-
-
0.00667
Ac-YQEFDEMEECASHLP
-
-
0.143
acetyl-DEMEECASHLPYK-(epsilon-NHCOCH3)
-
presence of inhibitor peptide 4Apep21-34KK
0.21 - 1.7
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
0.62 - 2.5
anthranilyl-DDIVPAbu[C(O)-O]AMY(3-NO2)TW-OH
0.034
Boc-Gly-Arg-Arg-AMC
-
-
0.073
Boc-RVRR-7-amido-4-methylcoumarin
-
pH 8.0, 18°C
0.111
Bz-norleucine-lysine-arginine-arginine-AMC
-
-
0.05 - 0.243
DEMEECSQHLPYI
0.05 - 0.317
DTEDVVCCSMSYTWTGK
0.083 - 6.08
EAGDDIVPCSMSYTWTGA-OH
0.8
EAGDNIVPCSMSYTWTGA-OH
-
pH 7.5, wild-type enzyme
0.7
EAGNDIVPCSMSYTWTGA-OH
-
pH 7.5, wild-type enzyme
0.67 - 6.08
EAGNNIVPCSMSYTWTGA-OH
0.18 - 0.6
EDVV-4-aminobutyryl-CSMSY
0.012 - 0.2
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide
0.0065
o-aminobenzoyl (Abz)-L-Asp-L-Asp-L-Ile-L-Val-L-Pro-L-Cys-L-Ser-L-Met-L-Ser-L-Tyr(3-NO2)-L-Thr-NH2
-
pH 7.3, 30°C
43
Pyr-RTKR-7-amido-4-methylcoumarin
-
pH 8.0, 18°C
0.062
Z-RR-7-amido-4-methylcoumarin
-
pH 8.0, 18°C
additional information
additional information
-
-
-
0.0431
2-Naph-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant V154F
1.08
2-Naph-Lys-Lys-Arg-p-nitroanilide
-
-
0.006
7-methoxycoumarin-4-acetyl-DEMEECASHLPYK-(epsilon-NHCOCH3)
-
-
0.15
7-methoxycoumarin-4-acetyl-DEMEECASHLPYK-(epsilon-NHCOCH3)
-
presence of inhibitor peptide 4Apep21-34KK
0.6
Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-AbuPSI[COO]-Ala-Ser-Lys(QSY-7)-amide
-
-
1
Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-AbuPSI[COO]-Ala-Ser-Lys(QSY-7)-amide
-
operating at wavelengths 524 nm/600 nm (excitation/emission)
1.2
Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-AbuPSI[COO]-Ala-Ser-Lys(QSY-7)-amide
-
operating at wavelengths 515 nm/605 nm (excitation/emission)
7.2
Ac-Asp-Glu-Lys(TAMRA)-Glu-Glu-AbuPSI[COO]-Ala-Ser-Lys(QSY-7)-amide
-
in the presence of 0.0174% DDM
0.00167
Ac-DEEMECASHLPYK-NH2
-
wild-type NS3 protease, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT
0.00183
Ac-DEEMECASHLPYK-NH2
-
wild-type NS3 protease, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT, 150 mM NaCl
0.0233
Ac-DEEMECASHLPYK-NH2
-
wild-type NS3 protease plus cofactor NS4A, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT
0.0253
Ac-DEEMECASHLPYK-NH2
-
engineered single-chain protease, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT
0.0255
Ac-DEEMECASHLPYK-NH2
-
engineered single-chain protease plus cofactor NS4A, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT
0.0267
Ac-DEEMECASHLPYK-NH2
-
wild-type or engineered single-chain protease plus cofactor NS4A, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT, 150 mM NaCl
0.03
Ac-DEEMECASHLPYK-NH2
-
engineered single-chain protease, in 50 mM HEPES buffer, pH 7.5, 0.1% 1-O-n-octyl-beta-D-glucopyranoside, 15% glycerol, 30 mM DTT, 150 mM NaCl
0.033
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 3 mutant D168Q, 30°C, pH 6.5
0.095
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 and 3 mutant V132L, 30°C, pH 6.5
0.13
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 3 mutant R123T, 30°C, pH 6.5
0.133
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant V78A/D79E/Q80G/S122K/V321L, 30°C, pH 6.5
0.16
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant V78A/D79E/Q80G, 30°C, pH 6.5
0.2
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant T160A, 30°C, pH 6.5
0.22
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant D79E, 30°C, pH 6.5
0.22
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant Q80G, 30°C, pH 6.5
0.25
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant S122K/V132L, 30°C, pH 6.5
0.25
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 3 mutant R123T/D168Q, 30°C, pH 6.5
0.3
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant V78A, 30°C, pH 6.5
0.3
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 3 mutant R123T/D168Q/V132L, 30°C, pH 6.5
0.4
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 1b enzyme, 30°C, pH 6.5
0.43
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 enzyme, 30°C, pH 6.5
0.57
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 3 enzyme, 30°C, pH 6.5
0.58
Ac-DTEDVVP(Nva)-O-4-phenylazophenyl ester
genotype 2 mutant S122K, 30°C, pH 6.5
0.011
Ac-KPGLKR-4-nitroanilide
-
mutant D129A, pH 9.5, 37°C
0.019
Ac-KPGLKR-4-nitroanilide
-
mutant D129E, pH 9.5, 37°C
0.038
Ac-KPGLKR-4-nitroanilide
-
mutant D129N, pH 9.5, 37°C
0.133
Ac-KPGLKR-4-nitroanilide
-
mutant Y150F, pH 9.5, 37°C
0.394
Ac-KPGLKR-4-nitroanilide
-
mutant S160A, pH 9.5, 37°C
0.872
Ac-KPGLKR-4-nitroanilide
-
mutant V115A, pH 9.5, 37°C
0.965
Ac-KPGLKR-4-nitroanilide
-
wild-type, pH 9.5, 37°C
1.5
Ac-KPGLKR-4-nitroanilide
-
37°C, pH 9.5
6.08
Ac-KPGLKR-4-nitroanilide
-
mutant V115A, pH 9.5, 37°C
6.08
Ac-KPGLKR-4-nitroanilide
-
wild-type, pH 9.5, 37°C
0.2
Ac-L-Asp-L-Glu-L-Asp-(EDANS)-L-Glu-L-Glu-alpha-aminobutyric acid-PSI[COO]-L-Ala-L-Ser-L-Lys-(DABCYL)-NH2
mutant A156T, pH 7.8, 30°C
0.6
Ac-L-Asp-L-Glu-L-Asp-(EDANS)-L-Glu-L-Glu-alpha-aminobutyric acid-PSI[COO]-L-Ala-L-Ser-L-Lys-(DABCYL)-NH2
mutant A156V, pH 7.8, 30°C
1
Ac-L-Asp-L-Glu-L-Asp-(EDANS)-L-Glu-L-Glu-alpha-aminobutyric acid-PSI[COO]-L-Ala-L-Ser-L-Lys-(DABCYL)-NH2
wild-type, pH 7.8, 30°C
0.018
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant T111L
0.04
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant I162F
0.051
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant T111F
0.245
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant V154L
0.266
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
-
0.297
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant V166L
0.314
Ac-Leu-Gln-Tyr-Thr-Lys-Arg-p-nitroanilide
-
NS3 mutant M156A
0.036
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant D129E
0.048
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant D129A
0.057
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant V154F
0.06
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant T111L
0.164
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant I162F
0.181
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant A164V
0.198
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant T111F
0.26
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant A164S
0.638
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant V166L
0.733
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant I155F
0.778
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant M156A
0.8
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
NS3 mutant V154L
1.64
Ac-Leu-Lys-Lys-Arg-p-nitroanilide
-
-
0.21
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
-
enzyme from hepatitis C virus genotype 4a, in 1 M MES (pH 5.8), at 23°C
0.77
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
-
enzyme from hepatitis C virus genotype 1b, in 1 M MES (pH 5.8), at 23°C
0.83
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
-
enzyme from hepatitis C virus genotype 6a, in 1 M MES (pH 5.8), at 23°C
0.85
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
-
enzyme from hepatitis C virus genotype 2a, in 1 M MES (pH 5.8), at 23°C
1.7
anthraniloyl-DDIVP-Abu[C(O)-O] AMY(3-NO2)-TW-OH
-
enzyme from hepatitis C virus genotype 5a, in 1 M MES (pH 5.8), at 23°C
0.62
anthranilyl-DDIVPAbu[C(O)-O]AMY(3-NO2)TW-OH
-
mutant full-length protease M485A/V524A/Q562A, at 23°C
2.5
anthranilyl-DDIVPAbu[C(O)-O]AMY(3-NO2)TW-OH
-
single chain NS3 protease domain, at 23°C
0.05
DEMEECSQHLPYI
-
absence of cofactor
0.243
DEMEECSQHLPYI
-
presence of cofactor
0.05
DTEDVVCCSMSYTWTGK
-
protease NS3(1-181)/NS4A
0.167
DTEDVVCCSMSYTWTGK
-
protease NS3(1-631)/NS4A(1-54)
0.317
DTEDVVCCSMSYTWTGK
-
protease NS4A(21-32)-GSGS-NS3(3-181)
0.083
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme K136M/R109Q
0.167
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme K136M
0.59
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R109Q
0.7
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, wild-type enzyme
0.72
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme K165S/R161S
0.77
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R161S
0.78
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R155S
0.85
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R123T
0.95
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme K165S
6.08
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme K165S/R161S
6.08
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R109Q
6.08
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R155S
6.08
EAGDDIVPCSMSYTWTGA-OH
-
pH 7.5, mutant enzyme R161S
0.67
EAGNNIVPCSMSYTWTGA-OH
-
pH 7.5, wild-type enzyme
6.08
EAGNNIVPCSMSYTWTGA-OH
-
pH 7.5, wild-type enzyme
0.18
EDVV-4-aminobutyryl-CSMSY
-
absence of cofactor
0.6
EDVV-4-aminobutyryl-CSMSY
-
presence of cofactor
0.012
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide
-
absence of cofactor
0.2
Glu-Asp-Val-Val-4-aminobutyryl-Cys-p-nitroanilide
-
presence of cofactor