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BRENDA support

3.4.21.98: hepacivirin

This is an abbreviated version!
For detailed information about hepacivirin, go to the full flat file.

Word Map on EC 3.4.21.98

Reaction

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' =

Synonyms

Cpro-2, Cpro-2 proteinase, Den2 protease, HCV NS3, HCV NS3 protease, HCV NS3/4A, HCV NS3/4A protease, Hepacivirin, hepatitis C virus NS3 serine protease, hepatitis C virus NS3/4A protease, non-structural 3 protein, nonstructural 3 protease, nonstructural protein 3, nonstructural protein 3-4A serine protease, nonstructural protein 3-4Agene, nonstructural protein 3/4A protease, NS2/3 protease, NS2B-NS3 proteinase, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3 serine proteinase, NS3-4A, NS3-4A protease, NS3-4A serine protease, NS3-4A serine protease complex, NS3-4A serine proteinase, NS3-NS4A protease, NS3-protease, NS3-SP, NS3/4a, NS3/4A protease, NS3/4A protease complex, NS3/4A serine protease, NS34Agene, NS3?4A, NS5A-5B protease, P70, polyprotein-processing proteinase NS3, proteinase NS3, proteinase, polyprotein-processing, NS3, sc-protease, serine protease NS3, serine proteinase NS3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.98 hepacivirin

Source Tissue

Source Tissue on EC 3.4.21.98 - hepacivirin

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
additional information
-
baseline NS3 quasispecies diversity and complexity is higher in acutely infected subjects compared to a chronic hepatitis C control group. Both parameters are comparable in patients with spontaneous clearance versus treatment-induced acute hepatitis C or development of chronic hepatitis C. Longitudinal NS3 quasispecies kinetics show a trend to a decreasing diversity and complexity within 4 weeks in patients with spontaneous clearance compared to the other groups
Manually annotated by BRENDA team