3.4.21.98: hepacivirin

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For detailed information about hepacivirin, go to the full flat file.

Word Map on EC 3.4.21.98

3.4.21.98

ribavirin

virologic

helicase

direct-acting

replicons

telaprevir

cirrhosis

pegylated

anti-hcv

boceprevir

hcv-infected

resistance-associated

simeprevir

macrocyclic

dengue

peginterferon

sofosbuvir

subgenomic

unwind

treatment-naive

treatment-experienced

interferon-free

flaviviridae

mavs

flavivirus

hcv-specific

rbv

daclatasvir

asunaprevir

ntpase

peg-ifn

pan-genotypic

rig-i

non-nucleoside

ledipasvir

ns2b

quasispecies

ritonavir

drug development

1-infected

bluetongue

alfa-2a

ifn-free

relapsers

interferon-based

pestivirus

hcv-rna

ns2b-ns3

all-oral

irf-3

hcv-1b

molecular biology

analysis

pharmacology

medicine

Reaction

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' =

Synonyms

Cpro-2, Cpro-2 proteinase, Den2 protease, HCV NS3, HCV NS3 protease, HCV NS3/4A, HCV NS3/4A protease, Hepacivirin, hepatitis C virus NS3 serine protease, hepatitis C virus NS3/4A protease, non-structural 3 protein, nonstructural 3 protease, nonstructural protein 3, nonstructural protein 3-4A serine protease, nonstructural protein 3-4Agene, nonstructural protein 3/4A protease, NS2/3 protease, NS2B-NS3 proteinase, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3 serine proteinase, NS3-4A, NS3-4A protease, NS3-4A serine protease, NS3-4A serine protease complex, NS3-4A serine proteinase, NS3-NS4A protease, NS3-protease, NS3-SP, NS3/4a, NS3/4A protease, NS3/4A protease complex, NS3/4A serine protease, NS34Agene, NS3?4A, NS5A-5B protease, P70, polyprotein-processing proteinase NS3, proteinase NS3, proteinase, polyprotein-processing, NS3, sc-protease, serine protease NS3, serine proteinase NS3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.98 hepacivirin

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Results	in table
19	Activating Compound
54	AA Sequence
37	Application
1	CAS Registry Number
41	Cloned(Commentary)
19	Cofactor
19	Crystallization (Commentary)
17	General Information
1	General Stability
266	IC50 Value
948	Inhibitors
7	kcat/KM [mM/s]
565	Ki Value [mM]
146	KM Value [mM]
2	Localization
6	Metals/Ions
13	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
158	Organism
157	PDB ID
9	pH Optimum
3	pH Stability
1	Posttranslational Modification
273	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
145	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
9	Subunits
158	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
140	Turnover Number [1/s]

Purification

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Purification on EC 3.4.21.98 - hepacivirin

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2 entries

HiTrap heparin column chromatography, HiTrap SP-HP column chromatography, and Superdex 75 gel filtration

Hepacivirus C

707507

minimal precursor (residues 9041206 of the hepatitis C virus polyprotein) purified from insoluble inclusion bodies by solubilization in 6 M guanidine hydrochloride and metal chelate resin affinity chromatography

Hepacivirus C

O92972

681415

mutant V36M purified by Ni-resin and gel filtraton

Hepacivirus C

690462

nickel affinity resin column chromatography and poly-uridine affinity resin column chromatography

Hepacivirus C

707390

on Ni2+ affinity column

Yellow fever virus

681172

recombinant GST-tagged enzyme from Escherichia coli TOP cells by glutathione affinity chromatography

Hepatitis C virus genotype 4a

O39929

753354

recombinant protein, autolytic conversion of 36 kDa NS2B-NS3 construct into the 30 kDa NS3 enzyme

West Nile virus

667522

recombinant single-chain protease

Hepacivirus C

81440, 81441

single-chain NS3-4A protein purified by gel filtration and on Ni2+-NTA fast flow column, more than 85% pure

Hepacivirus C

690400

wild-type or mutants R155K, R155T, R155S, and R155I purified on affinity resin and by gel filtration. Purity over 90% (wild type and R155K) or around 80% (R155T and R155S)

Hepacivirus C

692999