3.4.21.98: hepacivirin

This is an abbreviated version!
For detailed information about hepacivirin, go to the full flat file.

Reaction

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1' =

Synonyms

Cpro-2, Cpro-2 proteinase, Den2 protease, HCV NS3, HCV NS3 protease, HCV NS3/4A, HCV NS3/4A protease, Hepacivirin, hepatitis C virus NS3 serine protease, hepatitis C virus NS3/4A protease, non-structural 3 protein, nonstructural 3 protease, nonstructural protein 3, nonstructural protein 3-4A serine protease, nonstructural protein 3-4Agene, nonstructural protein 3/4A protease, NS2/3 protease, NS2B-NS3 proteinase, NS2B/NS3 protease, NS3, NS3 protease, NS3 protein, NS3 proteinase, NS3 serine protease, NS3 serine proteinase, NS3-4A, NS3-4A protease, NS3-4A serine protease, NS3-4A serine protease complex, NS3-4A serine proteinase, NS3-NS4A protease, NS3-protease, NS3-SP, NS3/4a, NS3/4A protease, NS3/4A protease complex, NS3/4A serine protease, NS34Agene, NS3?4A, NS5A-5B protease, P70, polyprotein-processing proteinase NS3, proteinase NS3, proteinase, polyprotein-processing, NS3, sc-protease, serine protease NS3, serine proteinase NS3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.98 hepacivirin

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Results	in table
19	Activating Compound
54	AA Sequence
37	Application
1	CAS Registry Number
41	Cloned(Commentary)
19	Cofactor
19	Crystallization (Commentary)
17	General Information
1	General Stability
266	IC50 Value
948	Inhibitors
7	kcat/KM [mM/s]
565	Ki Value [mM]
146	KM Value [mM]
2	Localization
6	Metals/Ions
13	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
158	Organism
157	PDB ID
9	pH Optimum
3	pH Stability
1	Posttranslational Modification
273	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
145	Reference
2	Source Tissue
2	Specific Activity [micromol/min/mg]
4	Storage Stability
146	Substrates and Products (Substrate)
9	Subunits
158	Synonyms
4	Temperature Optimum [°C]
3	Temperature Stability [°C]
140	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.98 - hepacivirin

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

18810

Hepacivirus C

-

electrospray mass spectrometry

81447

18867

Hepacivirus C

-

1 * 18867, NS3 protease domain residues from 1029-1206, mass spectrometry

81435

19000

Hepacivirus C

O92972

NS3 fragment after autocleavage, Western blotting

681415

19540

Hepacivirus C

-

truncated form of the protease, lacking the N-terminal Met-Ala, mass spectrometry

81438

20000

Hepacivirus C

-

1 * 20000, NS3 proteinase residues 1-189

81433

20100

Hepacivirus C

-

1 * 23600, SDS-PAGE, 1 * 20100, calculation from cDNA sequence

81448

21080

Hepacivirus C

-

mass spectroscopy

717962

22800

Hepacivirus C

-

gel filtration

81448

23600

Hepacivirus C

-

1 * 23600, SDS-PAGE, 1 * 20100, calculation from cDNA sequence

81448

30000

West Nile virus

-

x * 30000, mature protein, SDS-PAGE

667522

32000

West Nile virus

-

x * 32000, SDS-PAGE

669368

35000

Hepacivirus C

O92972

full length protein, Western blotting

681415

70000

Hepacivirus C

-

x * 70000, SDS-PAGE

653748