3.4.21.95: Snake venom factor V activator

This is an abbreviated version, for detailed information about Snake venom factor V activator, go to the full flat file.

Reaction

Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545!Ser-Asn-Asn-Gly bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO2 =

Synonyms

blood coagulation factor V-activating proteinase, Factor V activator, Factor V-activating enzyme, Factor V-activating proteinase alpha, Factor V-activating proteinase gamma, FV activating enzymes, Human blood coagulation Factor V activating enzymes, LVV-V, Russell's viper venom factor V (FV) activator, RVV-V, RVV-Vgamma, Snake venom factor V activator alpha, Snake venom factor V activator gamma, VLFVA

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.95 Snake venom factor V activator