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3.4.21.93: Proprotein convertase 1

This is an abbreviated version!
For detailed information about Proprotein convertase 1, go to the full flat file.

Word Map on EC 3.4.21.93

Reaction

release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.93 Proprotein convertase 1

Reference

Reference on EC 3.4.21.93 - Proprotein convertase 1

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steiner, D.F.; Smeekens, S.P.; Ohagi, S.; Chan, S.J.
The new enzymology of precursor processing endoproteases
J. Biol. Chem.
267
23435-23438
1992
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Jean, F.; Basak, A.; DiMaio, J.; Seidah, N.G.; Lazure, C.
An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor
Biochem. J.
307
689-695
1995
Homo sapiens
Manually annotated by BRENDA team
Smeekens, S.P.; Avruch, A.S.; LaMendola, J.; Chan, S.J.; Steiner, D.F.
Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
Proc. Natl. Acad. Sci. USA
88
340-344
1991
Mus musculus
Manually annotated by BRENDA team
Seidah, N.G.; Chretien, M.
Pro-protein convertases of subtilisin/kexin family
Methods Enzymol.
244
175-188
1994
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, Q.L.; Jansen, E.; Brent, G.A.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by thyroid hormone
Am. J. Physiol. Endocrinol. Metab.
280
E160-170
2001
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Basak, A.; Lazure, C.
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes
Biochem. J.
373
231-239
2003
Mus musculus
Manually annotated by BRENDA team
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.; Brechler, V.
Two activation states of the prohormone convertase PC1 in the secretory pathway
J. Biol. Chem.
272
15184-15188
1997
Mus musculus
Manually annotated by BRENDA team
Boudreault, A.; Gauthier, D.; Lazure, C.
Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin
J. Biol. Chem.
273
31574-31580
1998
Mus musculus
Manually annotated by BRENDA team
Viale, A.; Ortola, C.; Hervieu, G.; Furuta, M.; Barbero, P.; Steiner, D.F.; Seidah, N.G.; Nahon, J.L.
Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals
J. Biol. Chem.
274
6536-6545
1999
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Manually annotated by BRENDA team
Jutras, I.; Seidah, N.G.; Reudelhuber, T.L.
A predicted alpha-helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway
J. Biol. Chem.
275
40337-40343
2000
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Basak, A.; Koch, P.; Dupelle, M.; Fricker, L.D.; Devi, L.A.; Chretien, M.; Seidah, N.G.
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1
J. Biol. Chem.
276
32720-32728
2001
Mus musculus
Manually annotated by BRENDA team
Li, Q.L.; Jansen, E.; Friedman, T.C.
Regulation of prohormone convertase 1 (PC1) by gp130-related cytokines
Mol. Cell. Endocrinol.
158
143-152
1999
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Muller, L.; Lindberg, I.
The cell biology of the prohormone convertases PC1 and PC2
Prog. Nucleic Acid Res. Mol. Biol.
63
69-108
1999
Drosophila sp. (in: flies), Mus musculus, no activity in Caenorhabditis elegans, Rattus norvegicus, no activity in Lymnaea stagnalis
Manually annotated by BRENDA team
Boudreault, A.; Gauthier, D.; Rondeau, N.; Savaria, D.; Seidah, N.G.; Chretien, M.; Lazure, C.
Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells
Protein Expr. Purif.
14
353-366
1998
Mus musculus
Manually annotated by BRENDA team
Bonic, A.; Mackin, R.B.
Expression, purification, and PC1-mediated processing of human proglucagon, glicentin, and major proglucagon fragment
Protein Expr. Purif.
28
15-24
2003
Homo sapiens
Manually annotated by BRENDA team
Stettler, H.; Suri, G.; Spiess, M.
Proprotein convertase PC3 is not a transmembrane protein
Biochemistry
44
5339-5345
2005
Homo sapiens
Manually annotated by BRENDA team
Tzimas, G.N.; Chevet, E.; Jenna, S.; Nguyen, D.T.; Khatib, A.M.; Marcus, V.; Zhang, Y.; Chretien, M.; Seidah, N.; Metrakos, P.
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases
BMC Cancer
5
149
2005
Homo sapiens
Manually annotated by BRENDA team
Marzban, L.; Trigo-Gonzalez, G.; Zhu, X.; Rhodes, C.J.; Halban, P.A.; Steiner, D.F.; Verchere, C.B.
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide
Diabetes
53
141-148
2004
Mus musculus
Manually annotated by BRENDA team
Posner, S.F.; Vaslet, C.A.; Jurofcik, M.; Lee, A.; Seidah, N.G.; Nillni, E.A.
Stepwise posttranslational processing of pro-growth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1
Endocrine
23
199-213
2004
Mus musculus
Manually annotated by BRENDA team
Dey, A.; Norrbom, C.; Zhu, X.; Stein, J.; Zhang, C.; Ueda, K.; Steiner, D.F.
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
Endocrinology
145
1961-1971
2004
Mus musculus
Manually annotated by BRENDA team
Dey, A.; Lipkind, G.M.; Rouille, Y.; Norrbom, C.; Stein, J.; Zhang, C.; Carroll, R.; Steiner, D.F.
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon
Endocrinology
146
713-727
2005
Mus musculus
Manually annotated by BRENDA team
Salvas, A.; Benjannet, S.; Reudelhuber, T.L.; Chretien, M.; Seidah, N.G.
Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi
FEBS Lett.
579
5621-5625
2005
Mus musculus
Manually annotated by BRENDA team
Mulcahy, L.R.; Vaslet, C.A.; Nillni, E.A.
Prohormone-convertase 1 processing enhances post-Golgi sorting of prothyrotropin-releasing hormone-derived peptides
J. Biol. Chem.
280
39818-39826
2005
Rattus norvegicus
Manually annotated by BRENDA team
Ugleholdt, R.; Poulsen, M.L.; Holst, P.J.; Irminger, J.C.; Orskov, C.; Pedersen, J.; Rosenkilde, M.M.; Zhu, X.; Steiner, D.F.; Holst, J.J.
Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor
J. Biol. Chem.
281
11050-11057
2006
Mus musculus
Manually annotated by BRENDA team
Rabah, N.; Gauthier, D.; Wilkes, B.C.; Gauthier, D.J.; Lazure, C.
Single amino acid substitution in the PC1/3 propeptide can induce significant modifications of its inhibitory profile toward its cognate enzyme
J. Biol. Chem.
281
7556-7567
2006
Mus musculus (P63239)
Manually annotated by BRENDA team
Sanchez, V.C.; Goldstein, J.; Stuart, R.C.; Hovanesian, V.; Huo, L.; Munzberg, H.; Friedman, T.C.; Bjorbaek, C.; Nillni, E.A.
Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone
J. Clin. Invest.
114
357-369
2004
Rattus norvegicus
Manually annotated by BRENDA team
Lee, S.N.; Prodhomme, E.; Lindberg, I.
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS
J. Endocrinol.
182
353-364
2004
Mus musculus
Manually annotated by BRENDA team
Henrich, S.; Lindberg, I.; Bode, W.; Than, M.E.
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity
J. Mol. Biol.
345
211-227
2004
Homo sapiens
Manually annotated by BRENDA team
Shen, X.; Li, Q.L.; Brent, G.A.; Friedman, T.C.
Thyroid hormone regulation of prohormone convertase 1 (PC1): regional expression in rat brain and in vitro characterization of negative thyroid hormone response elements
J. Mol. Endocrinol.
33
21-33
2004
Rattus norvegicus
Manually annotated by BRENDA team
Tagen, M.B.; Beinfeld, M.C.
Recombinant prohormone convertase 1 and 2 cleave purified pro cholecystokinin (CCK) and a synthetic peptide containing CCK 8 Gly Arg Arg and the carboxyl-terminal flanking peptide
Peptides
26
2530-2535
2005
Mus musculus
Manually annotated by BRENDA team
Rabah, N.; Gauthier, D.J.; Gauthier, D.; Lazure, C.
Improved PC1/3 production through recombinant expression in insect cells and larvae
Protein Expr. Purif.
37
377-384
2004
Mus musculus
Manually annotated by BRENDA team
Rabah, N.; Gauthier, D.; Dikeakos, J.D.; Reudelhuber, T.L.; Lazure, C.
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro
FEBS J.
274
3482-3491
2007
Mus musculus
Manually annotated by BRENDA team
Billova, S.; Galanopoulou, A.S.; Seidah, N.G.; Qiu, X.; Kumar, U.
Immunohistochemical expression and colocalization of somatostatin, carboxypeptidase-E and prohormone convertases 1 and 2 in rat brain
Neuroscience
147
403-418
2007
Rattus norvegicus
Manually annotated by BRENDA team
Espinosa, V.P.; Ferrini, M.; Shen, X.; Lutfy, K.; Nillni, E.A.; Friedman, T.C.
Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism
Am. J. Physiol. Endocrinol. Metab.
292
E175-E186
2007
Rattus norvegicus
Manually annotated by BRENDA team
Wideman, R.D.; Covey, S.D.; Webb, G.C.; Drucker, D.J.; Kieffer, T.J.
A switch from prohormone convertase (PC)-2 to PC1/3 expression in transplanted alpha-cells is accompanied by differential processing of proglucagon and improved glucose homeostasis in mice
Diabetes
56
2744-2752
2007
Mus musculus
Manually annotated by BRENDA team
Lloyd, D.J.; Bohan, S.; Gekakis, N.
Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice
Hum. Mol. Genet.
15
1884-1893
2006
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Manually annotated by BRENDA team
Farooqi, I.S.; Volders, K.; Stanhope, R.; Heuschkel, R.; White, A.; Lank, E.; Keogh, J.; ORahilly, S.; Creemers, J.W.
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
J. Clin. Endocrinol. Metab.
92
3369-3373
2007
Homo sapiens
Manually annotated by BRENDA team
Lou, H.; Smith, A.M.; Coates, L.C.; Cawley, N.X.; Loh, Y.P.; Birch, N.P.
The transmembrane domain of the prohormone convertase PC3: a key motif for targeting to the regulated secretory pathway
Mol. Cell. Endocrinol.
267
17-25
2007
Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Marandi, M.; Mowla, S.J.; Tavallaei, M.; Yaghoobi, M.M.; Jafarnejad, S.M.
Proprotein convertases 1 and 2 (PC1 and PC2) are expressed in neurally differentiated rat bone marrow stromal stem cells (BMSCs)
Neurosci. Lett.
420
198-203
2007
Rattus norvegicus
Manually annotated by BRENDA team
Rehfeld, J.F.; Zhu, X.; Norrbom, C.; Bundgaard, J.R.; Johnsen, A.H.; Nielsen, J.E.; Vikesaa, J.; Stein, J.; Dey, A.; Steiner, D.F.; Friis-Hansen, L.
Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17
Biochem. J.
415
35-43
2008
Mus musculus
Manually annotated by BRENDA team
Lankat-Buttgereit, B.; Mueller, S.; Schmidt, H.; Parhofer, K.G.; Gress, T.M.; Goeke, R.
Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
Biol. Cell
100
703-715
2008
Homo sapiens
Manually annotated by BRENDA team
Garruti, G.; Cotecchia, S.; Giampetruzzi, F.; Giorgino, F.; Giorgino, R.
Neuroendocrine deregulation of food intake, adipose tissue and the gastrointestinal system in obesity and metabolic syndrome
J. Gastrointestin. Liver Dis.
17
193-198
2008
Homo sapiens
Manually annotated by BRENDA team
Fox, D.L.; Good, D.J.
Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3
Mol. Endocrinol.
22
1438-1448
2008
Mus musculus
Manually annotated by BRENDA team
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
Neuroscience
156
788-799
2008
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zhou, J.; Cai, Z.H.
Molecular cloning and characterization of prohormone convertase 1 gene in abalone (Haliotis diversicolor supertexta)
Comp. Biochem. Physiol. B
155
331-339
2010
Haliotis diversicolor supertexta
Manually annotated by BRENDA team
Sun, J.; Zhang, C.; Fang, X.; Lei, C.; Lan, X.; Chen, H.
Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits
Biochem. Genet.
48
779-788
2010
Capra hircus (D8V3M2)
Manually annotated by BRENDA team
Ozawa, A.; Peinado, J.R.; Lindberg, I.
Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis
Endocrinology
151
4437-4445
2010
Mus musculus
Manually annotated by BRENDA team
Kilimnik, G.; Kim, A.; Steiner, D.; Friedman, T.; Hara, M.
Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic alpha-cells in mouse models of beta-cell regeneration
Islets
2
149-155
2010
Mus musculus
Manually annotated by BRENDA team
Zhan, S.; Zhou, A.; Lan, J.; Yang, T.
Proprotein convertase 1 mRNA and protein expression in ischemic rat cortex after reperfusion
Neural Regen. Res.
6
295-299
2011
Rattus norvegicus
-
Manually annotated by BRENDA team
Hiramoto, K.; Yamate, Y.; Kobayashi, H.; Ishii, M.; Sato, E.F.; Inoue, M.
Ultraviolet B irradiation of the mouse eye induces pigmentation of the skin more strongly than does stress loading, by increasing the levels of prohormone convertase 2 and alpha-melanocyte-stimulating hormone
Clin. Exp. Dermatol.
38
71-76
2013
Mus musculus (P63239)
Manually annotated by BRENDA team
Ozawa, S.; Katsuta, H.; Suzuki, K.; Takahashi, K.; Tanaka, T.; Sumitani, Y.; Nishida, S.; Yoshimoto, K.; Ishida, H.
Estimated proinsulin processing activity of prohormone convertase (PC) 1/3 rather than PC2 is decreased in pancreatic beta-cells of type 2 diabetic patients
Endocr. J.
61
607-614
2014
Homo sapiens (P29120)
Manually annotated by BRENDA team
Blanco, E.H.; Peinado, J.R.; Martin, M.G.; Lindberg, I.
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph
Endocrinology
155
3434-3447
2014
Homo sapiens (P29120)
Manually annotated by BRENDA team
Gagnon, H.; Refaie, S.; Gagnon, S.; Desjardins, R.; Salzet, M.; Day, R.
Proprotein convertase 1/3 (PC1/3) in the rat alveolar macrophage cell line NR8383: localization, trafficking and effects on cytokine secretion
PLoS ONE
8
e61557
2013
Rattus norvegicus
Manually annotated by BRENDA team
Wilschanski, M.; Abbasi, M.; Blanco, E.; Lindberg, I.; Yourshaw, M.; Zangen, D.; Berger, I.; Shteyer, E.; Pappo, O.; Bar-Oz, B.; Martin, M.G.; Elpeleg, O.
A novel familial mutation in the PCSK1 gene that alters the oxyanion hole residue of proprotein convertase 1/3 and impairs its enzymatic activity
PLoS ONE
9
e108878
2014
Homo sapiens (P29120)
Manually annotated by BRENDA team
Elferich, J.; Williamson, D.M.; David, L.L.; Shinde, U.
Determination of histidine pKa values in the propeptides of furin and proprotein convertase 1/3 using histidine hydrogen-deuterium exchange mass spectrometry
Anal. Chem.
87
7909-7917
2015
Homo sapiens (P29120)
Manually annotated by BRENDA team
Righi, A.; Faustini-Fustini, M.; Morandi, L.; Monti, V.; Asioli, S.; Mazzatenta, D.; Bacci, A.; Foschini, M.P.
The changing faces of corticotroph cell adenomas the role of prohormone convertase 1/3
Endocrine
56
286-297
2017
Homo sapiens (P29120)
Manually annotated by BRENDA team
Li, J.; Mao, Z.; Huang, J.; Xia, J.
PICK1 is essential for insulin production and the maintenance of glucose homeostasis
Mol. Biol. Cell
29
587-596
2018
Mus musculus
Manually annotated by BRENDA team
Duhamel, M.; Rodet, F.; Murgoci, A.N.; Desjardins, R.; Gagnon, H.; Wisztorski, M.; Fournier, I.; Day, R.; Salzet, M.
The proprotein convertase PC1/3 regulates TLR9 trafficking and the associated signaling pathways
Sci. Rep.
6
19360
2016
Mus musculus
Manually annotated by BRENDA team