3.4.21.93: Proprotein convertase 1

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For detailed information about Proprotein convertase 1, go to the full flat file.

Word Map on EC 3.4.21.93

3.4.21.93

obesity

proinsulin

proglucagon

subtilisin-like

endoproteases

medicine

tmem18

proneuropeptides

drug development

analysis

Reaction

release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.93 Proprotein convertase 1

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Results	in table
10	Activating Compound
905	AA Sequence
15	Application
1	CAS Registry Number
34	Cloned(Commentary)
359	Disease/ Diagnostics
2	Expression
6	General Information
47	Inhibitors
42	Ki Value [mM]
2	KM Value [mM]
22	Localization
5	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
379	Organism
3	PDB ID
8	pH Optimum
2	pH Range
7	Posttranslational Modification
28	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
73	Reference
68	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
83	Substrates and Products (Substrate)
5	Subunits
107	Synonyms
3	Temperature Optimum [°C]

Purification

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Purification on EC 3.4.21.93 - Proprotein convertase 1

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3 entries

a synthetic inhibitor can be used for developing an affinity purification procedure

recombinant enzyme

recombinant enzyme from insect cells and larvae, about 48fold from larvae by PEG precipitation, concanavalin A affinity and hydroxyapatite chromatography, and gel filtration

Mus musculus

670764

recombinant PC1/3 purified. PC1/3 CT peptide purified by His-affinity chromatography and RP-HPLC

Mus musculus

679776