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glucose-dependent insulinotropic polypeptide precursor + H2O
glucose-dependent insulinotropic polypeptide + propeptide of glucose-dependent insulinotropic polypeptide
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PC1/3 is essential for pro-GIP processing
GIP
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?
pro-cholecystokinin + H2O
N-terminal propeptide + C-terminal cholecystokinin 8 Gly Arg Arg peptide + remaining CCK peptide
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the substrate is only cleaved in vivo since defolding proteins ar required, in vitro the cleavage site is inaccessible for the enzyme
peptide product analysis
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?
pro-growth hormone-releasing hormone + H2O
growth hormone-releasing hormone + GHRH-RP + pro-peptide of growth hormone-releasing hormone
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posttranslational processing mechanism, PC1 is the primary enzyme involved in the processing, overview
-
-
?
pro-growth hormone-releasing hormone + H2O
growth hormone-releasing hormone + pro-peptide of growth hormone-releasing hormone
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PC1/3 and furin, EC 3.4.21.75, are major processing enzymes, processing overview
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-
?
pro-islet amyloid polypeptide + H2O
islet amyloid polypeptide + pro-peptides of islet amyloid polypeptide
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precursor of IAPP or amylin, the major component of islet amyloid, cleavage at the C- and N-terminus
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?
Pro-opiomelanocortin + H2O
?
pro-thyrotropin-releasing hormone + H2O
fragments of pro-thyrotropin-releasing hormone
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prohormone processing within the regulated secretory pathway of neuroendocrine cells
5 TRH peptide and 7 to 9 other peptides
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?
prothyrotropin-releasing hormone + H2O
thyrotropin-releasing hormone + pro-peptide of thyrotropin-releasing hormone
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processing and activation of the inactive prohormone is required for regulation of energy balance via leptin, enzyme regulation, overview
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?
additional information
?
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Pro-opiomelanocortin + H2O
?
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the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors
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?
Pro-opiomelanocortin + H2O
?
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the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors
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?
Proinsulin + H2O
?
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the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors
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?
Proinsulin + H2O
?
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the enzyme together with prohormone convertase 2 represents the major secretory granule processing activity responsible for processing neuroendocrine precursors
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?
additional information
?
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the potential cleavage site delineating the pro-domain, Arg102-Xaa-Lys-Arg, is remarkably conserved among different species and is preceded by two preserved Gln residues located in positions 96 and 97
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?
additional information
?
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biosynthesis of peptide hormones by processing of larger precursors
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?
additional information
?
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key enzyme capable of processing a variety of prohormones to their bioactive forms
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?
additional information
?
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cleaves polypeptide hormones and many proteins at specific sites
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?
additional information
?
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constitutive secretory pathway
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?
additional information
?
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implicated in processing of proproteins in the secretory pathway, synthesized as a zymogen, cleaves his own profragment in the endoplasmic reticulum
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?
additional information
?
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regulated secretory pathway
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?
additional information
?
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the enzyme is involved in the regulated secretory pathway in neuroendocrine cells
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?
additional information
?
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the enzyme is involved in the regulated secretory pathway in neuroendocrine cells, the enzyme activity is regulated by the PC1-propeptide and by proSAAS CT peptide
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?
additional information
?
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constitutive secretory pathway
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?
additional information
?
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key enzyme capable of processing a variety of prohormones to their bioactive forms
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?
additional information
?
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regulated secretory pathway
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?
additional information
?
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constitutive secretory pathway
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?