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3.4.21.93: Proprotein convertase 1

This is an abbreviated version!
For detailed information about Proprotein convertase 1, go to the full flat file.

Word Map on EC 3.4.21.93

Reaction

release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.93 Proprotein convertase 1

Localization

Localization on EC 3.4.21.93 - Proprotein convertase 1

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation. Co-localization of PC1/3 and Toll-like receptor 4 is found upon lipopolysaccharide stimulation
Manually annotated by BRENDA team
enzyme is activated in secretory vesicles at pH 5.5
Manually annotated by BRENDA team
additional information