3.4.21.93: Proprotein convertase 1
This is an abbreviated version!
For detailed information about Proprotein convertase 1, go to the full flat file.
Reaction
release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds
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Synonyms
Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3
ECTree
Localization
Localization on EC 3.4.21.93 - Proprotein convertase 1
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brenda
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brenda
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in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation. Co-localization of PC1/3 and Toll-like receptor 4 is found upon lipopolysaccharide stimulation
brenda
enzyme is activated in secretory vesicles at pH 5.5
brenda
Drosophila sp. (in: flies)
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rough endoplasmic reticulum
brenda
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brenda
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brenda
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Golgi-distal compartments
brenda
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early Golgi
brenda
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the enzyme is part of the regulated secretory pathway of neuroendocrine cells
brenda
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in NR-8383 cells, convertase PC1/3 is localized at the trans-Golgi network and traffics to lysosome-related vesicles upon lipopolysaccharide stimulation
brenda
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peripherally attached to the secretory granule membrane, the enzyme is no transmembrane protein, subcellular localization analysis, overview
brenda
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brenda
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full length PC3 is associated with lipid rafts in Neuro2A cells, undergoes stimulated secretion and is colocalized with the secretory granule marker, chromogranin A, by immunocytochemistry
brenda
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peripherally attached to the granule membrane
brenda
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brenda
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the enzyme is part of the regulated secretory pathway of neuroendocrine cells
brenda
additional information
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the enzyme is transferred through the endoplasmic reticulum membrane
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brenda
additional information
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lacks a hydrophobic transmembrane anchor, but has a potential C-terminal amphipathic helical segment similar to the putative membrane anchor of carboxypeptidase H
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brenda
additional information
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the enzyme is localized in the regulated secretory pathway of neuroendocrine cells
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brenda