3.4.21.93: Proprotein convertase 1
This is an abbreviated version!
For detailed information about Proprotein convertase 1, go to the full flat file.
Word Map on EC 3.4.21.93
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3.4.21.93
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obesity
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proinsulin
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proglucagon
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subtilisin-like
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endoproteases
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medicine
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tmem18
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proneuropeptides
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drug development
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analysis
- 3.4.21.93
- obesity
- proinsulin
- proglucagon
-
subtilisin-like
- endoproteases
- medicine
-
tmem18
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proneuropeptides
- drug development
- analysis
Reaction
release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =
Synonyms
Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3
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3.4.21.93 Proprotein convertase 1Advanced search results
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results (Inhibitors
Inhibitors on EC 3.4.21.93 - Proprotein convertase 1
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
PC1/3 CT peptide
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decreases PC1/3 activity at high concentrations (micromol range)
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proSAAS CT peptide
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endogenous inhibitor, inhibits the C-terminal PC1 processing
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Synthetic inhibitor
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can be used for developing an affinity purification procedure
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morphine
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human prohormone convertase 1/3 promoter activity is 73.1% in GH3-mu-opioid receptor cells receiving morphine compared with cells receiving media, and this reduction is reversed by naltrexone. In cells transfected with the prohormone convertase 1/3-minusCRE1/2 promoter construct, morphine does not reduce prohormone convertase 1/3-promoter activity. In wild-type GH3 cells (without the mu-opioid receptor), human prohormone convertase 1/3 promoter does not respond to morphine treatment. Regulation of prohormone convertase 1/3 promoter activity by morphine is mediated through the mu-opioid receptor
morphine
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short-term morphine (24 h) exposure downregulates prohormone convertase 1/3 protein levels in the rat hypothalamus. The cyclic-AMP response element in the promoter of prohormone convertase 1/3 is required for morphine-induced regulation of prohormone convertase 1/3
PC1/3 propeptide
inhibits the mature enzyme competitively, inhibition mechanism, interaction with the enzyme at the 50RRSRR54, 61KR62 and 65DDD67 sequences, molecular modeling, overview
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additional information
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proprotein convertase 1/3 expression is reduced in Bon-1 cells overexpressing Pdcd4
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additional information
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in wild-type mice prohormone convertase 1/3 mRNA levels show a 75% reduction with food deprivation and exceed ad libitum-fed levels after leptin treatment. Hypothalamic prohormone convertase 1/3 mRNA levels in N2KO mice show no significant variation between the deprived condition and ad libitum feeding. Leptin-treated N2KO mice have significantly lower prohormone convertase 1/3 mRNA levels than leptin-treated wild-type mice
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additional information
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starvation reduces the serum levels of leptin which decreases PC1 expression, the effect can be reversed by administration of exogenous leptin
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additional information
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hyperthyroidism suppresses enzyme expression in hypothalamus and cerebral cortex
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