3.4.21.93: Proprotein convertase 1

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For detailed information about Proprotein convertase 1, go to the full flat file.

Reaction

release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =

Synonyms

Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.93 Proprotein convertase 1

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Results	in table
10	Activating Compound
905	AA Sequence
15	Application
1	CAS Registry Number
34	Cloned(Commentary)
359	Disease/ Diagnostics
2	Expression
6	General Information
47	Inhibitors
42	Ki Value [mM]
2	KM Value [mM]
22	Localization
5	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
379	Organism
3	PDB ID
8	pH Optimum
2	pH Range
7	Posttranslational Modification
28	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
73	Reference
68	Source Tissue
4	Specific Activity [micromol/min/mg]
1	Storage Stability
83	Substrates and Products (Substrate)
5	Subunits
107	Synonyms
3	Temperature Optimum [°C]

General Information

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General Information on EC 3.4.21.93 - Proprotein convertase 1

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Haliotis diversicolor supertexta

-

PC members are paralogous genes derived from a common ancestor, which represents independent lineages by gene replication in evolution. Abalone PC1 is located in PC1 clade which is orthologous genes in different species. The potential cleavage site delineating the pro-domain, Arg102-Xaa-Lys-Arg, is remarkably conserved among different species and is preceded by two preserved Gln residues located in positions 96 and 97

708226

physiological function

5 entries

physiological function

Haliotis diversicolor supertexta

-

PC1 is a potential prohormone processing enzyme and plays a critical role in abalone physiological processes related to reproduction

708226

physiological function

Haliotis diversicolor supertexta

-

the enzyme plays a key role in the posttranslational processing of precursors for bioactive peptides

708226

physiological function

Rattus norvegicus

-

downregulation of convertase PC1/3 by shRNA produces a phenotype in NR-8383 cells similar to isolated peritoneal macrophages. PC1/3 shRNA induces changes in the cellular organization and expression of the specific trafficking regulator RAB GTPase. NR-8383 cells down-regulated for PC1/3 present an abnormal cytokine secretion profile

732724

physiological function

Mus musculus

-

conditional Pick1-knockout mice lacking protein interacting with C-kinase 1, show elevated proinsulin levels in the circulation and in the pancreatic islets, accompanied by a reduction in the proinsulin processing enzyme prohormone convertase 1/3. The deletion of Pick1 triggers the specific elimination of chromogranin B in pancreatic beta cells

754678

physiological function

Mus musculus

-

proprotein convertase PC1/3 regulates the endosomal toll-like receptor TLR9. Under CpG oligodesoxynucleotide challenge, PC1/3 traffics rapidly to colocalize with TLR9 in CpG oligodesoxynucleotide-containing endosomes with acidic pH. In PC1/3 knockdown macrophages, compartmentalization of TLR9 is altered and TLR9 clustered in multivesicular bodies. This clustering of TLR9 in multivesicular bodies dampens the anti-inflammatory STAT3 signalling pathway while it promotes the pro-inflammatory NF-kappaB pathway

755417