3.4.21.93: Proprotein convertase 1
This is an abbreviated version!
For detailed information about Proprotein convertase 1, go to the full flat file.
Word Map on EC 3.4.21.93
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3.4.21.93
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obesity
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proinsulin
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proglucagon
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subtilisin-like
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endoproteases
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medicine
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tmem18
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proneuropeptides
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drug development
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analysis
- 3.4.21.93
- obesity
- proinsulin
- proglucagon
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subtilisin-like
- endoproteases
- medicine
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tmem18
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proneuropeptides
- drug development
- analysis
Reaction
release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-/- bonds =
Synonyms
Furin homolog, More, mPC1, mPC1/3, mPC3, mSPC3, murine PC1/3, murine proprotein convertase-1, murine proprotein convertase-1/3, Neuroendocrine convertase 1, PC 1/3, PC1, PC1/3, PC1/PC3, PC3, PCI, PCSK1, prohormone convertase, prohormone convertase 1, prohormone convertase 1/3, Prohormone convertase 3, prohormone convertase PC3, prohormone-convertase 1, propeptide convertase, Propeptide processing protease, proprotein convertase 1, proprotein convertase 1/3, proprotein convertase PC1, proprotein convertase PC1/3, protein convertase 1/3
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
analysis
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highly specific and potent PC1 inhibitors proSAAS-(235-246) and proSAAS-(235-244) may be useful in development of an effective affinity procedure for the purification of PC1
drug development
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repression of proprotein convertase 1/3 by Pdcd4 may represent a novel mechanism for the function of Pdcd4 as a tumour suppressor
medicine
additional information
medicine
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extension of the clinical and molecular spectrum of human congenital PC1/3 deficiency
medicine
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Pc1 N222D homozygous mice are obese and mimic humans with mutations in PC1. This mutation will be a valuable resource in understanding the role of prohormone processing in energy homeostasis
medicine
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transplantation of PC1/3-expressing alpha-cells prevents streptozotocin-induced hyperglycemia by preserving beta-cell area and islet morphology, possibly via stimulating beta-cell replication. Expression of PC1/3 rather than PC2 in alpha-cells induces glucagon-like peptide 1 and glucagon-like peptide 2 production and converts the alpha-cell from a hyperglycemia-promoting cell to one that lowers blood glucose levels. Alteration of proglucagon processing in the alpha-cell may be therapeutically useful in the context of type 1 diabetes
medicine
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downregulation of prohormone convertase 1/3 by short-term morphine and upregulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse
medicine
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downregulation of prohormone convertase 1/3 by short-term morphine and upregulation by long-term morphine treatment may be a signal mediating the switch from drug use to drug abuse
medicine
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significant activation of PC1/3 in the alpha-cells of pancreatic islet is observed in mouse models of insulin resistance such as pregnant, obese, diabetic and prediabetic NOD mice. Data suggest a role of alpha-cells for beta-cell proliferation and further for the endocrine cell network within an islet
medicine
prohormone convertase 1/3 activity is significantly lower in type 2 diabetic patients than in the control group. Decreased activity of prohormone convertase 1/3 rather than prohormone convertase 2 in pancreatic beta-cells is involved in the impaired proinsulin processing, resulting in elevated intact proinsulin levels in type 2 diabetic patients
medicine
UVB irradiation to the eye and stress loading increase the expression of prohormone convertase 1/3 and prohormone convertase 2 in the pituitary gland. The increase in expression of pituitary prohormone convertase 2 is greater in animals subjected to UVB eye irradiation than to stress, whereas no difference is seen between the two groups for the increase in PC1/3
medicine
role of prohormone convertase 1/3 in the transformation of corticotroph cell adenomas into Cushing's disease. Prohormone convertase 1/3 expression is negative or weak in the three patients in the initial phase of corticotroph cell adenoma, while a strong expression is observed in the majority of neoplastic cells in tissue specimens obtained from the same three patients at the time of recurrence as Cushing's disease
medicine
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Pc1 N222D homozygous mice are obese and mimic humans with mutations in PC1. This mutation will be a valuable resource in understanding the role of prohormone processing in energy homeostasis
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additional information
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PC1 may be a potential target for the maturation of somatostatin
additional information
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PC1/3, through its various domains, is capable of controlling its enzymatic activity in all regions of the cell that it encounters
additional information
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transmembrane domain of PC3 plays a key role in sorting the enzyme to the regulated secretory pathway
