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3.4.21.91: Flavivirin

This is an abbreviated version!
For detailed information about Flavivirin, go to the full flat file.

Word Map on EC 3.4.21.91

Reaction

Selective hydrolysis of -Xaa-Xaa-/-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala =

Synonyms

Dengue NS2b-NS3 protease, Dengue NS3 protease, dengue virus non-structural protein 3, dengue virus NS2B-NS3 protease, dengue virus protease, dengue virus serotype 2 protease, DENV NS2B-NS3, DENV-2 NS2B-NS3 protease, DENV2 NS2BNS3pro, DV2 NS2B/NS3pro, flavivirus NS2B-NS3 protease, non-structural protein 3 serine protease, non-structural protein NS2B-NS3 protease, nonstructural protein 3, NS2-3 protease, NS2B-3 proteinase, NS2B-NS3 complex, NS2B-NS3 protease, NS2B-NS3 protease-helicase, NS2B-NS3 proteinase, NS2B-NS3 proteolytic complex, NS2B-NS3 serine protease, NS2B-NS3 serine proteinase, NS2B-NS3(pro)teinase, NS2b-NS3-protease, NS2B-NS3p, NS2B-NS3pro, NS2B/3 protease, NS2B/NS3, NS2B/NS3 complex, NS2B/NS3 protease, NS2B/NS3 protease complex, NS2B/NS3 proteinase, NS2B/NS3 serine protease, NS2B/NS3pro serine protease, NS2B18NS3, NS2BNS3(pro)tease, NS3, NS3 protease, NS3 proteinase, NS3 serine protease, NS3pro, two-component NS2B-NS3 protease, viral serine protease NS2B/NS3, WNV NS2B-NS3, Yellow fever virus (flavivirus) protease, yellow fever virus NS2B-NS3-181 protease, YFV NS2B/NS3 protease, Zika protease, Zika virus NS2B-NS3 protease, ZIKV NS2B/NS3 protease, ZIKV protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.91 Flavivirin

KI Value

KI Value on EC 3.4.21.91 - Flavivirin

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0442 - 5.5
(2S)-4-[3-(aminomethyl)phenyl]-2-([(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide
0.0136 - 10.8
(2S)-4-[4-(aminomethyl)phenyl]-2-([(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]butanamide
0.0216
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[3-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide
-
pH 8.5, 22°C
0.0853 - 17.1
(2S)-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-4-[4-(carbamimidamidomethyl)phenyl]-2-([(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]amino)butanamide
0.0034
2-([[3,6-bis(2,6-dimethylphenyl)-7-oxo-2-thioxo-2,3,6,7-tetrahydro[1,3]thiazolo[4,5-d]pyrimidin-5-yl]sulfanyl]methyl)-7-chloro-4H-pyrido[1,2-a]pyrimidin-4-one
-
serotype 4, pH 7.5, 37°C
0.00011
4-(guanidinomethyl)-phenylacetyl-Lys-Lys-Arg-NH2
-
pH 8.5, 22°C
0.021
4-hydroxypanduratin
-
pH and temperature not specified in the publication
0.021
4-hydroxypanduratin A
-
-
0.0049
4-[3-acetyl-5-(2-phenylquinolin-4-yl)-2,3-dihydro-1,3,4-oxadiazol-2-yl]benzoic acid
-
serotype 4, pH 7.5, 37°C
0.00082
5,6-dichloro-2H-triazolo[4,5-b]pyrazine
pH 8.0, 20°C
0.004
5-[(4-chloro-3-nitro-1H-pyrazol-1-yl)methyl]-N-[1-[2-(diethylamino)ethyl]-1H-benzimidazol-2-yl]furan-2-carboxamide
-
serotype 4, pH 7.5, 37°C
0.0667
Ac-EVKKQR-NH2
-
pH 9.0, 37°C
0.0259
Ac-FAAGRK-NH2
-
pH 9.0, 37°C
0.1523
Ac-GKR-NH2
-
pH 9.0, 37°C
0.0223
Ac-KKR-NH2
-
pH 9.0, 37°C
0.1215
Ac-KR-NH2
-
pH 9.0, 37°C
0.0121
Ac-RTSKKR-NH2
-
pH 9.0, 37°C
0.1876
Ac-SKKR-NH2
-
pH 9.0, 37°C
0.046
Ac-TTSTRR-NH2
-
pH 9.0, 37°C
0.0111 - 0.0153
agathisflavone
0.000264
antibody D05320
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.0004
antibody D05321
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.00017
antibody D05322
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.000031
antibody D05323
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.000058
antibody D05444
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.000035
antibody D05445
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.000288
antibody D05446
-
wild type enzyme, in 20 mM Tris/HCl buffer, pH 8.0, at 22°C
-
0.000000079 - 0.00007
Aprotinin
0.00075
Bz-Ala-Lys-Arg-Arg
-
-
0.0053
Bz-Ala-Lys-Arg-Arg-H
-
-
0.00085
Bz-Arg-Arg
-
-
0.012
Bz-Arg-Arg-H
-
-
0.0094
Bz-D-Nle-Lys-Arg-Arg-H
-
-
0.0004
Bz-Lys-Arg-Arg
-
-
0.0015
Bz-Lys-Arg-Arg-H
-
-
0.0437
Bz-N-Me-Nle-Lys-Arg-Arg-H
-
-
0.0013
Bz-Nle-(3-amino)-Phe-(3-imino)-Phe-(3,4-dimethoxy)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0018
Bz-Nle-(3-guanidino)-Phe-(4-guanidino)-Phe-(4-guanidino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0002
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-(4-amino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.002
Bz-Nle-(4-amino)-Phe-(3-guanidino)-Phe-Arg
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0017
Bz-Nle-(4-amino)-Phe-(3-imino)-Phe-Arg
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0018
Bz-Nle-(4-amino)-Phe-(4-guanidino)-Phe-Trp
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0009
Bz-Nle-Ala-Arg-Arg
-
-
0.0221
Bz-Nle-Ala-Arg-Arg-H
-
-
0.0015
Bz-Nle-Arg-(3-guanidino)-Phe-(4-amino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0286
Bz-Nle-D-Lys-Arg-Arg-H
-
-
0.0001
Bz-Nle-His-(3-guanidino)-Phe-(4-guanidino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0008
Bz-Nle-His-(3-guanidino)-Phe-beta-(2-naphthyl)-Ala
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0017
Bz-Nle-His-(3-imino)-Phe-Arg
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0018
Bz-Nle-His-(4-guanidino)-Phe-(4-guanidino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0009
Bz-Nle-His-(4-guanidino)-Phe-Trp
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0005
Bz-Nle-homo-His-(3-guanidino)-Phe-(4-guanidino)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0019
Bz-Nle-homoHis-(3-guanidino)-Phe-Arg
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0014
Bz-Nle-homoHis-(4-guanidino)-Phe-(4-phenyl)-Phe
-
predicted inhibition constant, pH and temperature not specified in the publication
0.125
Bz-Nle-Lys-Ala-Arg
-
-
0.5
Bz-Nle-Lys-Ala-Arg-H
-
-
0.138
Bz-Nle-Lys-Arg-(p-Cl)Phe-H
-
-
0.0186
Bz-Nle-Lys-Arg-(p-CN)Phe-H
-
-
0.0028
Bz-Nle-Lys-Arg-(p-guanidinyl)Phe-H
-
-
0.006
Bz-Nle-Lys-Arg-(p-Me)Phe-H
-
-
0.0116
Bz-Nle-Lys-Arg-(p-Ph)Phe-H
-
-
0.03315
Bz-Nle-Lys-Arg-Ala
-
-
0.193
Bz-Nle-Lys-Arg-Ala-H
-
-
0.0004
Bz-Nle-Lys-Arg-Arg
-
-
0.178
Bz-Nle-Lys-Arg-Arg(OH)-CONH-Bn
-
-
0.000043
Bz-Nle-Lys-Arg-Arg-B(OH)2
-
-
0.0829
Bz-Nle-Lys-Arg-Arg-benzoxazole
-
-
0.00085
Bz-Nle-Lys-Arg-Arg-CF3
-
-
0.0058
Bz-Nle-Lys-Arg-Arg-H
-
-
0.1275
Bz-Nle-Lys-Arg-Arg-NH2
-
-
0.5
Bz-Nle-Lys-Arg-Arg-NHSO2CF3
-
-
0.5
Bz-Nle-Lys-Arg-Arg-OH
-
-
0.0428
Bz-Nle-Lys-Arg-Arg-thiazole
-
-
0.051
Bz-Nle-Lys-Arg-D-Arg-H
-
-
0.5
Bz-Nle-Lys-Arg-homoPhe-H
-
-
0.0112
Bz-Nle-Lys-Arg-Lys
-
-
0.0205
Bz-Nle-Lys-Arg-Lys-H
-
-
0.062
Bz-Nle-Lys-Arg-Phe
-
-
0.0159
Bz-Nle-Lys-Arg-Phe-H
-
-
0.033
Bz-Nle-Lys-Arg-Phg-H
-
-
0.0016
Bz-Nle-Lys-Arg-Trp
-
predicted inhibition constant, pH and temperature not specified in the publication
0.0075
Bz-Nle-Lys-Arg-Trp-H
-
-
0.115
Bz-Nle-Lys-D-Arg-Arg-H
-
-
0.0012
Bz-Nle-Lys-Lys-Arg
-
-
0.00005
Bz-Nle-Lys-Lys-Arg-B(OH)2
-
-
0.0413
Bz-Nle-Lys-Lys-Arg-H
-
-
0.0474
Bz-Nle-Lys-N-Me-Arg-Arg-H
-
-
0.0156
Bz-Nle-Lys-Phe-Arg
-
-
0.0407
Bz-Nle-Lys-Phe-Arg-H
-
-
0.109
Bz-Nle-Lys-Pro-Arg-H
-
-
0.5
Bz-Nle-Lys-Thr-Arg-H
-
-
0.5
Bz-Nle-Lys-Thr-Arg-NH2
-
-
0.5
Bz-Nle-Lys-Thr-Arg-OH
-
-
0.1133
Bz-Nle-N-Me-Lys-Arg-Arg-H
-
-
0.0015
Bz-Nle-Phe-Arg-Arg
-
-
0.0158
Bz-Nle-Phe-Arg-Arg-H
-
-
0.0614
Bz-Nle-Pro-Arg-Arg-H
-
-
0.00025
Bz-Phe-Lys-Arg-Arg
-
-
0.0068
Bz-Phe-Lys-Arg-Arg-H
-
-
0.377
cardamonin
-
-
0.0004
Cbz-Lys-Arg-(4-GuPhe)P(OPh)2
-
pH 8.5, 37°C
0.0007
Cbz-Lys-Arg-(4-GuPhg)P(OPh)2
-
pH 8.5, 37°C
0.00012
Cbz-Lys-Arg-Arg
-
pH 8.5, 37°C
0.003
Cbz-Lys-Arg-ArgP(OPh)2
-
pH 8.5, 37°C
0.008
Cbz-Lys-Arg-LysP(OPh)2
-
pH 8.5, 37°C
0.0004
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
-
0.013
diphenyl (1-[[(benzyloxy)carbonyl]amino]-3-carbamimidamidopropyl)phosphonate
-
pH 8.5, 37°C
0.022
diphenyl (5-amino-1-[[(benzyloxy)carbonyl]amino]pentyl)phosphonate
-
pH 8.5, 37°C
0.01
diphenyl [[[(benzyloxy)carbonyl]amino](4-carbamimidamidophenyl)methyl]phosphonate
-
pH 8.5, 37°C
0.004
diphenyl [[[(benzyloxy)carbonyl]amino](carbamimidamido)methyl]phosphonate
-
pH 8.5, 37°C
0.0047 - 0.0257
myricetin
0.0182 - 14.7
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-(4-carbamimidamidophenyl)-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
0.0994
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[3-(carbamimidamidomethyl)cyclohexa-1,5-dien-1-yl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
pH 8.5, 22°C
0.0756
N-[(2S)-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-4-[4-(carbamimidamidomethyl)phenyl]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
pH 8.5, 22°C
0.134
N-[(2S)-4-[3-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-lysinamide
-
pH 8.5, 22°C
0.0289
N-[(2S)-4-[4-(aminomethyl)phenyl]-1-[[(trans-4-carbamimidamidocyclohexyl)methyl]amino]-1-oxobutan-2-yl]-N2-(phenylacetyl)-L-ornithinamide
-
pH 8.5, 22°C
0.0298
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-(3-carbamimidamidophenyl)-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
pH 8.5, 22°C
0.0296 - 31.1
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[3-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
0.044
N-[(trans-4-carbamimidamidocyclohexyl)methyl]-N2-[(2S)-4-[4-(carbamimidamidomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-L-lysinamide
-
pH 8.5, 22°C
0.00068
N2-(1,3-benzodioxol-5-ylacetyl)-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.000039
N2-(1,3-thiazol-2-yl)-L-arginyl-N-[(1S)-2-amino-2-oxo-1-(4-[[4-(trifluoromethyl)benzyl]oxy]phenyl)ethyl]-L-lysinamide
-
pH 8.5, 37°C
0.00075
N2-(4-[(Z)-[3-(cyclohexylmethyl)-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]benzoyl)-L-lysyl-N-[(1S)-2-amino-2-oxo-1-phenylethyl]-L-lysinamide
-
pH 8.5, 37°C
0.07
N2-(adamant-1-yl(amino)acetyl)-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.0138
N2-(adamant-1-ylacetyl)-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.0025
N2-(biphenyl-3-ylacetyl)-L-lysyl-N-[(1-carbamimidoylpiperidin-4-yl)methyl]-L-lysinamide
-
pH 8.0, 25°C
0.000006
N2-(biphenyl-4-ylacetyl)-L-lysyl-L-Lys-L-Arg-aldehyde
-
pH 8.5, 37°C
0.00053
N2-(biphenyl-4-ylacetyl)-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.0048 - 0.0263
N2-(cyclohexylacetyl)-L-lysyl-L-lysinamide
0.00247
N2-(phenylacetyl)-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.027
N2-(phenylacetyl)-L-lysyl-L-lysine
-
pH 8.5, 22°C
0.14
N2-(phenylacetyl)-L-lysyl-L-lysyl-3-methylvalinamide
-
pH 8.5, 22°C
0.075
N2-(phenylacetyl)-L-lysyl-L-lysyl-D-alaninamide
-
pH 8.5, 22°C
0.025
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-alaninamide
-
pH 8.5, 22°C
0.2
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-prolinamide
-
pH 8.5, 22°C
0.105
N2-(phenylacetyl)-L-lysyl-L-lysyl-L-valinamide
-
pH 8.5, 22°C
0.05
N2-(phenylacetyl)-L-lysyl-L-lysyl-N2-methylglycinamide
-
pH 8.5, 22°C
0.00256
N2-(phenylacetyl)-L-lysyl-L-lysylglycinamide
-
pH 8.5, 22°C
0.00156
N2-(phenylacetyl)-L-lysyl-N-(2-aminoprop-2-en-1-yl)-L-lysinamide
-
pH 8.5, 22°C
0.015
N2-(phenylacetyl)-L-lysyl-N-(4-amino-4-oxobutyl)-L-lysinamide
-
pH 8.5, 22°C
0.017
N2-(phenylacetyl)-L-lysyl-N-(5-amino-5-oxopentyl)-L-lysinamide
-
pH 8.5, 22°C
0.0012
N2-(phenylacetyl)-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
pH 8.5, 22°C
0.000009
N2-phenylacetyl-L-Lys-L-Lys-L-Arg-aldehyde
-
pH 8.5, 37°C
0.0222
N2-[(2S)-4-[3-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
pH 8.5, 22°C
0.00471 - 12.4
N2-[(2S)-4-[4-(aminomethyl)phenyl]-2-[(phenylacetyl)amino]butanoyl]-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
0.00013
N2-[(3,4-dichlorophenyl)acetyl]-L-lysyl-N-[(1S)-1-(1-carbamimidoylpiperidin-4-yl)-2-oxoethyl]-L-lysinamide
-
pH 8.5, 37°C
0.00011
N2-[(3,4-dichlorophenyl)acetyl]-L-ornithyl-N-[(trans-4-carbamimidamidocyclohexyl)methyl]-L-lysinamide
-
pH 8.5, 22°C
0.00113
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.0018
N2-[(3,4-dimethylphenyl)acetyl]-L-lysyl-L-lysylglycinamide
-
pH 8.5, 22°C
0.0012
N2-[(3-aminophenyl)acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00054
N2-[(4-hydroxyphenyl)acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00418
N2-[(acetylamino)(phenyl)acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.0036
N2-[amino(phenyl)acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00036
N2-[[3-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00018
N2-[[3-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00038
N2-[[4-(aminomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.00645 - 0.0831
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-3-methyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
0.00065 - 0.0116
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-arginyl-N-(4-carbamimidoylbenzyl)-L-argininamide
0.00082 - 0.00122
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-lysyl-N-(4-carbamimidoylbenzyl)-L-argininamide
0.0057 - 0.0773
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-arginyl-L-valyl-N-(4-carbamimidoylbenzyl)-L-argininamide
0.00011
N2-[[4-(carbamimidamidomethyl)phenyl]acetyl]-L-lysyl-L-lysinamide
-
pH 8.5, 22°C
0.000006
nona-D-Arg-amide
-
-
0.025
panduratin A
0.345
pinostrobin
-
-
0.0199 - 0.0227
quercetin
0.01984
[4-methyl-5-(3-methylbut-2-en-1-yl)-6-phenylcyclohex-3-en-1-yl](2,4,6-trimethoxyphenyl)methanone
-
pH and temperature not specified in the publication
0.02436
[5-(3-methylbut-2-en-1-yl)-6-phenylcyclohex-3-en-1-yl](2,4,6-trimethoxyphenyl)methanone
-
pH and temperature not specified in the publication
0.03968
[6-(4-methoxyphenyl)-4-methyl-5-(3-methylbut-2-en-1-yl)cyclohex-3-en-1-yl](2,4,6-trimethoxyphenyl)methanone
-
pH and temperature not specified in the publication
additional information
additional information
-