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3.4.21.9: enteropeptidase

This is an abbreviated version!
For detailed information about enteropeptidase, go to the full flat file.

Word Map on EC 3.4.21.9

Reaction

Activation of trypsinogen by selective cleavage of Lys6-/-Ile bond =

Synonyms

BEK, BEP, bovine enterokinase light chain, bovine enteropeptidase, Chinese bovine enterokinase, Chinese northern yellow bovine enterokinase catalytic subunit, EC 3.4.4.8, EK, EKL, EKL-His6, EKLC, enterokinase, enterokinase light chain, enteropeptidase, enteropeptidase light chain, EP 118-1035, EP-1, EPL, HEK, HEP, human enteropeptidase, L-BEP, L-HEK, L-HEP, native enterokinase, natural enteropeptidase, peptidase, entero-, porcine enterokinase, PRSS7, recombinant bovine enterokinase catalytic subunit protein, recombinant enterokinase light chain, recombinant His-tagged enterokinase light chain, rEKL, rEKL/His, sBEKLC, TMPRSS15

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.9 enteropeptidase

Inhibitors

Inhibitors on EC 3.4.21.9 - enteropeptidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
alpha-tosyl-lysine chloromethyl ketone
-
-
antipain
Aprotinin
basic pancreatic trypsin inhibitor
reversible inhibition
-
benzamidine
bestatin
-
7% loss of activtity
chymostatin
-
20% loss of activtity
diisopropylphosphorofluoridate
-
-
dithiothreitol
-
10% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
E-64
-
50-85% loss of activtity
ethanol
-
80-40% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
imidazole
-
90-30% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
leupeptin
-
94% loss of activtity
N-tosyl-L-lysine chloromethyl ketone
-
13% loss of activtity
NaCl
-
at 100 and 250 mM, Gly-Asp-Asp-Asp-Asp-Lys-?-naphthylamide as substrate
pepstatin
-
5% loss of activtity
pepstatin A
-
5% loss of activtity
PMSF
-
50% loss of activtity
Protein C inhibitor
-
low molecular weight and unfractionated heparin slightly reduce the inhibitory effect of protein C inhibitor
-
SDS
-
40-70% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
Soybean trypsin inhibitor
-
trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
-
Triton X-100
-
30-80% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
Trypsin inhibitor
-
Tween-20
-
20-75% loss of activity, thiobenzyl benzyloxycarbonyl-L-lysinate as substrate
Val-(Asp)4-Lys-chloromethane
-
-
additional information
-
EDTA not inhibitory
-