3.4.21.89: Signal peptidase I

This is an abbreviated version!
For detailed information about Signal peptidase I, go to the full flat file.

Reaction

Cleavage of hydrophobic, N-terminal signal or leader sequences =

Synonyms

Bacterial leader peptidase 1, bacterial type I signal peptidase, big signal peptidase, canine signal peptidase complex, chloroplast processing peptidase, EC 3.4.99.36, Escherichia coli leader peptidase, Eukaryotic signal peptidase, Eukaryotic signal proteinase, hen oviduct signal peptidase, HOSP, imp1p, Leader peptidase, Leader peptidase I, Leader peptide hydrolase, Leader proteinase, LEP, LepB, PA1303, Pcp1, Peptidase, signal, Pilin leader peptidase, plastidic SPase I, plastidic SPase I 1, plastidic type I signal peptidase 1, Plsp1, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, protease IV, Proteinase, eukaryotic signal, Proteinase, signal, PuIO prepilin peptidase, Rv2903c, SEC11, secretory protein 11, Signal peptidase, signal peptidase I, signal peptidase I-3, Signal peptidase IB, signal peptidase type I, Signal peptide hydrolase, Signal peptide peptidase, Signalase, Sip1, Sip2, Sip3, SipP (pTA1015), SipP (pTA1040), SipS, SipT, SipU, SipV, SipW, SipX, SipY, SipZ, SP, SP I, SP-I, SPase, Spase I, SPase I 1, SPase IB, SPaseI, SPC, Spc1, SPI, SPP, SpsB, thylakoidal processing peptidase, TPP, type I signal (leader) peptidase, type I signal peptidase, type I signal peptidase 1, type I signal peptidase Sec11a, type I signal peptidase Sec11b, type I SPase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.89 Signal peptidase I

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Results	in table
15	Activating Compound
75654	AA Sequence
48	Application
1	CAS Registry Number
61	Cloned(Commentary)
7	Crystallization (Commentary)
287	Disease/ Diagnostics
104	General Information
2	General Stability
14	IC50 Value
187	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
43	KM Value [mM]
116	Localization
93	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
251	Organism
29	PDB ID
12	pH Optimum
5	pH Range
2	pH Stability
4	pI Value
10	Posttranslational Modification
95	Protein Variants
41	Purification (Commentary)
7	Reaction
1	Reaction Type
201	Reference
1	Renatured (Commentary)
15	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
248	Substrates and Products (Substrate)
42	Subunits
269	Synonyms
7	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
57	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.21.89 - Signal peptidase I

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

4 - 11

Pseudomonas aeruginosa

-

activity increases from pH 4.0-9.0, 85% of maximal activity at pH 11.0, no activity above pH 12.0

651885

4.5 - 9

Escherichia coli

-

20% of maximal activity at pH 4.5, half-maximal activity at pH 6.5, 90% of maximal activity at pH 7.0

650357

5 - 12

Staphylococcus aureus

-

activity range, inactive at or below pH 4.0 and at or above pH 13.0, profile, overview

708475

7.7 - 10

Escherichia coli

-

7.7: 57% of activity maximum, 10: maximum activity

29827

additional information

Staphylococcus aureus

-

pH-rate profile reveals apparent pKa values of 6.6 and 8.7

708475