3.4.21.89: Signal peptidase I

This is an abbreviated version!
For detailed information about Signal peptidase I, go to the full flat file.

Word Map on EC 3.4.21.89

3.4.21.89

polyproteins

lipoprotein

preproteins

cleavable

foot-and-mouth

unprocessed

dyad

membrane-spanning

prolipoproteins

translocons

pilins

uncleaved

beta-lactamase

drug development

flavivirus

ompa

nonstructural

cotranslationally

co-translational

sec-dependent

globomycin

presequence

papain-like

prepeptide

polytopic

oligonucleotide-directed

ns2b

signal-anchored

pharmacology

medicine

analysis

Reaction

Cleavage of hydrophobic, N-terminal signal or leader sequences =

Synonyms

Bacterial leader peptidase 1, bacterial type I signal peptidase, big signal peptidase, canine signal peptidase complex, chloroplast processing peptidase, EC 3.4.99.36, Escherichia coli leader peptidase, Eukaryotic signal peptidase, Eukaryotic signal proteinase, hen oviduct signal peptidase, HOSP, imp1p, Leader peptidase, Leader peptidase I, Leader peptide hydrolase, Leader proteinase, LEP, LepB, PA1303, Pcp1, Peptidase, signal, Pilin leader peptidase, plastidic SPase I, plastidic SPase I 1, plastidic type I signal peptidase 1, Plsp1, Prokaryotic leader peptidase, Prokaryotic signal peptidase, Prokaryotic signal proteinase, Propeptidase, protease IV, Proteinase, eukaryotic signal, Proteinase, signal, PuIO prepilin peptidase, Rv2903c, SEC11, secretory protein 11, Signal peptidase, signal peptidase I, signal peptidase I-3, Signal peptidase IB, signal peptidase type I, Signal peptide hydrolase, Signal peptide peptidase, Signalase, Sip1, Sip2, Sip3, SipP (pTA1015), SipP (pTA1040), SipS, SipT, SipU, SipV, SipW, SipX, SipY, SipZ, SP, SP I, SP-I, SPase, Spase I, SPase I 1, SPase IB, SPaseI, SPC, Spc1, SPI, SPP, SpsB, thylakoidal processing peptidase, TPP, type I signal (leader) peptidase, type I signal peptidase, type I signal peptidase 1, type I signal peptidase Sec11a, type I signal peptidase Sec11b, type I SPase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.89 Signal peptidase I

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Results	in table
15	Activating Compound
75654	AA Sequence
48	Application
1	CAS Registry Number
61	Cloned(Commentary)
7	Crystallization (Commentary)
287	Disease/ Diagnostics
104	General Information
2	General Stability
14	IC50 Value
187	Inhibitors
2	kcat/KM [mM/s]
4	Ki Value [mM]
43	KM Value [mM]
116	Localization
93	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
251	Organism
29	PDB ID
12	pH Optimum
5	pH Range
2	pH Stability
4	pI Value
10	Posttranslational Modification
95	Protein Variants
41	Purification (Commentary)
7	Reaction
1	Reaction Type
201	Reference
1	Renatured (Commentary)
15	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
248	Substrates and Products (Substrate)
42	Subunits
269	Synonyms
7	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
57	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.89 - Signal peptidase I

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0.0004 - 0.001

arylomycin A2

3 entries

0.00019

N-hexadecanoyl-N-methylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 190 nM

669256

0.00011

N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 110 nM

669256

0.00011

N-methyl-N-(12-methyltridecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 110 nM

669256

0.00013

N-methyl-N-(13-methyltetradecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 130 nM

669256

0.00013

N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 130 nM

669256

0.00017

N-methyl-N-(14-methylpentadecanoyl)serylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-4,18-dihydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 170 nM

669256

0.00013

N-methyl-N-pentadecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 130 nM

669256

0.00011

N-methyl-N-tetradecanoylserylalanyl-N-[13-carboxy-3-[(6-deoxyhexopyranosyl)oxy]-18-hydroxy-10-methyl-8,11-dioxo-9,12-diazatricyclo[13.3.1.12,6]icosa-1(19),2(20),3,5,15,17-hexaen-7-yl]-N-methylglycinamide

Escherichia coli

IC50: 110 nM

669256

0.00009

N-[(2S)-4-[(2S)-1-decanoylpyrrolidin-2-yl]-2-(1-hydroxyethyl)-4-oxobutanoyl]-L-alanyl-N1-[(2S)-1-oxopropan-2-yl]-L-aspartamide

Staphylococcus aureus

pH not specified in the publication, temperature not specified in the publication

696677

additional information

2 entries