3.4.21.84: limulus clotting factor C
This is an abbreviated version!
For detailed information about limulus clotting factor C, go to the full flat file.
Word Map on EC 3.4.21.84
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3.4.21.84
-
endothelial
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vegf-c
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lymphatic
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metastasis
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node
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lymphangiogenesis
-
lymph
-
vessel
-
lymphangiogenic
-
clinicopathological
-
coagulation
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horseshoe
-
crab
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azoospermia
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platelet-derived
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endotoxin
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receptor-3
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microdeletions
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microvessels
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factor-c
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lymphedema
-
zymogen
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hemocytes
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podoplanin
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tachypleus
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tridentatus
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lyve-1
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y-chromosome
-
amebocyte
-
oligozoospermia
-
lps-binding
-
loader
-
analysis
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pdgfc
-
sushi
- 3.4.21.84
- endothelial
- vegf-c
- lymphatic
- metastasis
- node
-
lymphangiogenesis
- lymph
- vessel
-
lymphangiogenic
-
clinicopathological
-
coagulation
-
horseshoe
- crab
- azoospermia
-
platelet-derived
- endotoxin
- receptor-3
-
microdeletions
-
microvessels
- factor-c
- lymphedema
- zymogen
- hemocytes
- podoplanin
- tachypleus
- tridentatus
-
lyve-1
-
y-chromosome
-
amebocyte
- oligozoospermia
-
lps-binding
-
loader
- analysis
-
pdgfc
-
sushi
Reaction
Selective cleavage of -Arg103-/-Ser- and -Ile124-/-Ile- bonds in limulus clotting factor B to form factor _overbar_B_. Cleavage of -Pro-Arg-/- bonds in synthetic substrates =
Synonyms
CrFC, Factor C, IscW_ISCW002489, Limulus factor C
ECTree
3.4.21.84 limulus clotting factor CAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.21.84 - limulus clotting factor C
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
lipopolysaccharide + H2O
?
binds a pathogen-associated LPS molecule to trigger a blood coagulation cascade
-
?
tert-butoxycarbonyl-Ala-Pro-Arg-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-Ala-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
tert-butoxycarbonyl-Asp(O-benzyl)-Pro-Arg-7-amido-4-methylcoumarin + H2O
tert-butoxycarbonyl-Asp(O-benzyl)-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Limulus clotting factor B
Limulus clotting factor Bbar
-
active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insoluble coagulin gel
-
-
?
Limulus clotting factor B
Limulus clotting factor Bbar
-
active factor Cbar selectively cleaves the Arg103-/-Ser104 and Ile124-/-Ile125 bonds in proenzyme factor B to form factor Bbar, which then activates proclotting enzyme to clotting enzyme. The resulting clotting enzyme acts on coagulogen, causing the formation of an insiluble coagulin gel
-
-
?
N-tert-Butoxycarbonyl-Asp(O-benzyl)-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
N-tert-Butoxycarbonyl-Asp(O-benzyl)-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Asp(O-benzyl)-Ala-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Asp(O-benzyl)-Ala-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Asp-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Asp-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Gln-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Glu(O-benzyl)-Gly-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Glu(O-benzyl)-Gly-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Glu(O-benzyl)-Gly-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Gly-Ala-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
tert-butoxycarbonyl-Ile-Gly-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Lys(benzyloxycarbonyl)-Gly-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Lys(benzyloxycarbonyl)-Gly-Arg-4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Lys-Gly-Arg 4-methylcoumaryl 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Met-Ala-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Ser(O-benzyl)-Ala-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Ser(O-benzyl)-Ala-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Val-Gly-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
Tert-Butoxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
-
?
additional information
?
-
blood coagulation cascade, which combines the function of hemostasis with immune response gainst gram-negative bacteria, besides blood coagulation and removal of endotoxin CrFC may be involved in cell signaling and protein-protein interaction
-
?
additional information
?
-
-
alpha-thrombin like specificity towards synthetic tripeptide substrates
-
-
?
additional information
?
-
-
factor C is an initiator in the hemolymph coagulation system of horseshoe crab (Limulus polyphemus, Tachypleus tridentatus)
-
-
?
additional information
?
-
-
factor C is essential for the endotoxin-mediated coagulation system
-
-
?
additional information
?
-
-
alpha-thrombin like specificity towards synthetic tripeptide substrates
-
-
?
additional information
?
-
-
factor C is an initiator in the hemolymph coagulation system of horseshoe crab (Limulus polyphemus, Tachypleus tridentatus)
-
-
?
