3.4.21.84: limulus clotting factor C

This is an abbreviated version, for detailed information about limulus clotting factor C, go to the full flat file.

Reaction

Selective cleavage of -Arg103-/-Ser- and -Ile124-/-Ile- bonds in limulus clotting factor B to form factor _overbar_B_. Cleavage of -Pro-Arg-/- bonds in synthetic substrates =

Synonyms

CrFC, Factor C, IscW_ISCW002489, Limulus factor C

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.84 limulus clotting factor C

Application

Application on EC 3.4.21.84 - limulus clotting factor C

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
analysis
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recombinant factor C assay for measuring endotoxin in house dust: comparison with LAL, and (1->3)-beta-D-glucans. In the Limulus amebocyte lysate assay endotoxin is detected through a reaction cascade, initiated by the binding of endotoxins to Factor C. The advantage of an assay using the genetically engineered factor Cbar in measuring endotoxins is that recombinant factor Cbar does not contain factor G that can produce interference from (1->3)-beta-D-glucans