3.4.21.83: Oligopeptidase B
This is an abbreviated version!
For detailed information about Oligopeptidase B, go to the full flat file.
Word Map on EC 3.4.21.83
-
3.4.21.83
-
gingivalis
-
prolyl
-
leupeptin
-
chymotrypsin-like
-
antipain
-
porphyromonas
-
aprotinin
-
chloromethyl
-
chymostatin
-
tlck
-
tryptase
-
2-macroglobulin
-
benzamidine
-
acrosin
-
phenylmethanesulfonyl
-
proteamaculans
-
bapna
-
drug development
-
medicine
- 3.4.21.83
- gingivalis
-
prolyl
- leupeptin
-
chymotrypsin-like
- antipain
- porphyromonas
- aprotinin
-
chloromethyl
- chymostatin
- tlck
- tryptase
-
2-macroglobulin
- benzamidine
- acrosin
-
phenylmethanesulfonyl
- proteamaculans
-
bapna
- drug development
- medicine
Reaction
Hydrolysis of -Arg-/-, -Lys-/- bonds in oligopeptides, even when P1' residue is proline =
Synonyms
La_OpB, oligopeptidase B, oligopeptidase B-like, oligopeptidase B2, OP-Tb, OPB, OPB2, OPBTc, Opd B, OpdB, Protease II, Proteinase, Escherichia coli alkaline, II, PSP, Spro_3467, Tb-OP, Tc 120, Tc-OP, trypsin-like protease
ECTree
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Reference on EC 3.4.21.83 - Oligopeptidase B
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kanatani, A.; Masuda, T.; Shimoda, T.; Misoka, F.; Lin, X.S.; Yoshimoto, T.; Tsuru, D.
Protease II from Escherichia coli: sequencing and expression of the enzyme gene and characterization of the expressed enzyme
J. Biochem.
110
315-320
1991
Escherichia coli
Pacaud, M.; Richaud, C.
Protease II from Escherichia coli. Purification and characterization
J. Biol. Chem.
250
7771-7779
1975
Escherichia coli
Tsuru, D.; Yoshimoto, T.
Oligopeptidase B: protease II from Escherichia coli
Methods Enzymol.
244
201-215
1994
Escherichia coli
Pacaud, M.
Protease II from Escherichia coli. Substrate specificity and kinetic properties
Eur. J. Biochem.
82
439-451
1978
Escherichia coli
Pacaud, M.
Purification of protease II from Escherichia coli by affinity chromatography and separation of two enzyme species from cells harvested at late log phase
Eur. J. Biochem.
64
199-204
1976
Escherichia coli
Kanatani, A.; Yoshimoto, T.; Nagai, H.; Ito, K.; Tsuru, D.
Location of the protease II gene (ptrB) on the physical map of the Escherichia coli chromosome
J. Bacteriol.
174
7881
1992
Escherichia coli
Hemerly, J.P.; Oliveira, V.; Del Nery, E.; Morty, R.E.; Andrews, N.W.; Juliano, M.A.; Juliano, L.
Subsite specificity (S3, S2, S1', S2' and S3') of oligopeptidase B from Trypanosoma cruzi and Trypanosoma brucei using fluorescent quenched peptides: comparative study and identification of specific carboxypeptidase activity
Biochem. J.
373
933-939
2003
Trypanosoma brucei, Trypanosoma cruzi
Polgar, L.
Oligopeptidase B: a new type of serine peptidase with a unique substrate-dependent temperature sensitivity
Biochemistry
38
15548-15555
1999
Escherichia coli
Juhasz, T.; Szeltner, Z.; Renner, V.; Polgar, L.
Role of the oxyanion binding site and subsites S1 and S2 in the catalysis of oligopeptidase B, a novel target for antimicrobial chemotherapy
Biochemistry
41
4096-4106
2002
Escherichia coli
Morty, R.E.; Fueloep, V.; Andrews, N.W.
Substrate recognition properties of oligopeptidase B from Salmonella enterica serovar Typhimurium
J. Bacteriol.
184
3329-3337
2002
Salmonella enterica (A0A0H3NCA6)
Caldas, C.; Cherqui, A.; Pereira, A.; Simoes, N.
Purification and characterization of an extracellular protease from Xenorhabdus nematophila involved in insect immunosuppression
Appl. Environ. Microbiol.
68
1297-1304
2002
Xenorhabdus nematophila
Morty, R.E.; Shih, A.Y.; Fulop, V.; Andrews, N.W.
Identification of the reactive cysteine residues in oligopeptidase B from Trypanosoma brucei
FEBS Lett.
579
2191-2196
2005
Trypanosoma brucei
Morty, R.E.; Pelle, R.; Vadasz, I.; Uzcanga, G.L.; Seeger, W.; Bubis, J.
Oligopeptidase B from Trypanosoma evansi. A parasite peptidase that inactivates atrial natriuretic factor in the bloodstream of infected hosts
J. Biol. Chem.
280
10925-10937
2005
Trypanosoma evansi (Q6QDP1), Trypanosoma evansi
Fernandes, L.C.; Bastos, I.M.; Lauria-Pires, L.; Rosa, A.C.; Teixeira, A.R.; Grellier, P.; Schrevel, J.; Santana, J.M.
Specific human antibodies do not inhibit Trypanosoma cruzi oligopeptidase B and cathepsin B, and immunoglobulin G enhances the activity of trypomastigote-secreted oligopeptidase B
Microbes Infect.
7
375-384
2005
Trypanosoma cruzi
Yan, J.B.; Wang, G.Q.; Du, P.; Zhu, D.X.; Wang, M.W.; Jiang, X.Y.
High-level expression and purification of Escherichia coli oligopeptidase B
Protein Expr. Purif.
47
645-650
2006
Escherichia coli
Rea, D.; Hazell, C.; Andrews, N.W.; Morty, R.E.; Fueloep, V.
Expression, purification and preliminary crystallographic analysis of oligopeptidase B from Trypanosoma brucei
Acta Crystallogr. Sect. F
62
808-810
2006
Trypanosoma brucei
Coetzer, T.H.; Goldring, J.P.; Huson, L.E.
Oligopeptidase B: a processing peptidase involved in pathogenesis
Biochimie
90
336-344
2008
Salmonella enterica, Rhodococcus erythropolis, Treponema denticola, Escherichia coli (P24555), Trypanosoma brucei (Q382P7), Trypanosoma cruzi (Q4CW30), Moraxella lacunata (Q59536)
de Matos Guedes, H.L.; Carneiro, M.P.; Gomes, D.C.; Rossi-Bergmanmn, B.; Giovanni de Simone, S.
Oligopeptidase B from L. amazonensis: molecular cloning, gene expression analysis and molecular model
Parasitol. Res.
101
853-863
2007
Leishmania amazonensis (A7XAB0), Leishmania amazonensis
Khairullin, R.F.; Mikhailova, A.G.; Sebyakina, T.Y.; Lubenets, N.L.; Ziganshin, R.H.; Demidyuk, I.V.; Gromova, T.Y.; Kostrov, S.V.; Rumsh, L.D.
Oligopeptidase B from Serratia proteamaculans. I. Determination of primary structure, isolation, and purification of wild-type and recombinant enzyme variants
Biochemistry (Moscow)
74
1164-1172
2009
Serratia proteamaculans (B3VI58), Serratia proteamaculans, Serratia proteamaculans 94 (B3VI58)
Usuki, H.; Uesugi, Y.; Iwabuchi, M.; Hatanaka, T.
Activation of oligopeptidase B from Streptomyces griseus by thiol-reacting reagents is independent of the single reactive cysteine residue
Biochim. Biophys. Acta
1794
1673-1683
2009
Streptomyces griseus
Mohd Ismail, N.I.; Yuasa, T.; Yuasa, K.; Nambu, Y.; Nisimoto, M.; Goto, M.; Matsuki, H.; Inoue, M.; Nagahama, M.; Tsuji, A.
A critical role for highly conserved Glu(610) residue of oligopeptidase B from Trypanosoma brucei in thermal stability
J. Biochem.
147
201-211
2010
Trypanosoma brucei
Mikhailova, A.G.; Khairullin, R.F.; Demidyuk, I.V.; Gromova, T.Y.; Kostrov, S.V.; Rumsh, L.D.
Oligopeptidase B from Serratia proteamaculans. II. Enzymatic characteristics: substrate analysis, influence of calcium ions, pH and temperature dependences
Biochemistry (Moscow)
76
480-490
2011
Serratia proteamaculans
McLuskey, K.; Paterson, N.G.; Bland, N.D.; Isaacs, N.W.; Mottram, J.C.
Crystal structure of Leishmania major oligopeptidase B gives insight into the enzymatic properties of a trypanosomatid virulence factor
J. Biol. Chem.
285
39249-39259
2010
Leishmania major (Q4QHU7), Leishmania major
Swenerton, R.K.; Zhang, S.; Sajid, M.; Medzihradszky, K.F.; Craik, C.S.; Kelly, B.L.; McKerrow, J.H.
The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion
J. Biol. Chem.
286
429-440
2011
Leishmania donovani (C9EF60), Leishmania donovani
Kangethe, R.T.; Boulange, A.F.; Coustou, V.; Baltz, T.; Coetzer, T.H.
Trypanosoma brucei brucei oligopeptidase B null mutants display increased prolyl oligopeptidase-like activity
Mol. Biochem. Parasitol.
182
7-16
2011
Trypanosoma brucei brucei
Mikhailova, A.G.; Khairullin, R.F.; Kolomijtseva, G.Y.; Rumsh, L.D.
Oligopeptidase B from Serratia proteamaculans. III. Inhibition analysis. Specific interactions with metalloproteinase inhibitors
Biochemistry (Moscow)
77
300-306
2012
Serratia proteamaculans (B3VI58), Serratia proteamaculans
Mohamed Mustafa, M.S.; Nakajima, Y.; Oyama, H.; Iwata, N.; Ito, K.
Assessment of substrate inhibition of bacterial oligopeptidase B
Biol. Pharm. Bull.
35
2010-2016
2012
Rhodococcus erythropolis (C0ZRJ2), Rhodococcus erythropolis, Stenotrophomonas maltophilia (K0J2A4), Stenotrophomonas maltophilia, Serratia marcescens (K0J8D4), Serratia marcescens, Escherichia coli (P24555), Escherichia coli
Fukumoto, J.; Ismail, N.I.; Kubo, M.; Kinoshita, K.; Inoue, M.; Yuasa, K.; Nishimoto, M.; Matsuki, H.; Tsuji, A.
Possible role of inter-domain salt bridges in oligopeptidase B from Trypanosoma brucei: critical role of Glu172 of non-catalytic beta-propeller domain in catalytic activity and Glu490 of catalytic domain in stability of OPB
J. Biochem.
154
465-473
2013
Trypanosoma brucei
Mattiuzzo, M.; De Gobba, C.; Runti, G.; Mardirossian, M.; Bandiera, A.; Gennaro, R.; Scocchi, M.
Proteolytic activity of Escherichia coli oligopeptidase B against proline-rich antimicrobial peptides
J. Microbiol. Biotechnol.
24
160-167
2014
Escherichia coli (P24555), Escherichia coli
Motta, F.; Bastos, I.; Faudry, E.; Ebel, C.; Lima, M.; Neves, D.; Ragno, M.; Barbosa, J.; de Freitas, S.; Santana, J.
The Trypanosoma cruzi virulence factor oligopeptidase B (OPBTc) assembles into an active and stable dimer
PLoS ONE
7
e30431
2012
Trypanosoma cruzi, Trypanosoma cruzi Brener
Canning, P.; Rea, D.; Morty, R.E.; Fueloep, V.
Crystal structures of Trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes
PLoS ONE
8
e79349
2013
Trypanosoma brucei brucei (O76728)
Mikhailova, A.G.; Khairullin, R.F.; Demidyuk, I.V.; Kostrov, S.V.; Grinberg, N.V.; Burova, T.V.; Grinberg, V.Y.; Rumsh, L.D.
Cloning, sequencing, expression, and characterization of thermostability of oligopeptidase B from Serratia proteamaculans, a novel psychrophilic protease
Protein Expr. Purif.
93
63-76
2014
Serratia proteamaculans (B3VI58), Serratia proteamaculans
Ovchinnikova, M.V.; Mikhailova, A.G.; Karlinsky, D.M.; Gorlenko, V.A.; Rumsh, L.D.
Reversible cyclic thermal inactivation of oligopeptidase B from Serratia proteamaculans
Acta Naturae
10
65-70
2018
Serratia proteamaculans (A8GHH5), Serratia proteamaculans, Serratia proteamaculans 568 (A8GHH5)
Mikhailova, A.G.; Nekrasov, A.N.; Zinchenko, A.A.; Rakitina, T.V.; Korzhenevsky, D.A.; Lipkin, A.V.; Razguljaeva, O.A.; Ovchinnikova, M.V.; Gorlenko, V.A.; Rumsh, L.D.
Truncated variants of Serratia proteamaculans oligopeptidase B having different activities
Biochemistry (Moscow)
80
1331-1343
2015
Serratia proteamaculans (A8GHH5), Serratia proteamaculans, Serratia proteamaculans 568 (A8GHH5)
Mikhailova, A.G.; Rakitina, T.V.; Timofeev, V.I.; Karlinsky, D.M.; Korzhenevskiy, D.A.; Agapova, Y.K.; Vlaskina, A.V.; Ovchinnikova, M.V.; Gorlenko, V.A.; Rumsh, L.D.
Activity modulation of the oligopeptidase B from Serratia proteamaculans by site-directed mutagenesis of amino acid residues surrounding catalytic triad histidine
Biochimie
139
125-136
2017
Serratia proteamaculans (B3VI58), Serratia proteamaculans
Sodero, A.C.; Dos Santos, A.C.; Mello, J.F.; De Jesus, J.B.; De Souza, A.M.; Rodrigues, M.I.; De Simone, S.G.; Rodrigues, C.R.; DE Matos Guedes, H.L.
Oligopeptidase B and B2 comparative modelling and virtual screening as searching tools for new antileishmanial compounds
Parasitology
144
536-545
2017
Leishmania amazonensis (A7XAB0), Leishmania amazonensis (A8QXT1), Leishmania amazonensis
Teixeira, P.C.; Velasquez, L.G.; Lepique, A.P.; de Rezende, E.; Bonatto, J.M.; Barcinski, M.A.; Cunha-Neto, E.; Stolf, B.S.
Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALB/c and BALB/c nude mice
PLoS Negl. Trop. Dis.
9
e0003411
2015
Leishmania amazonensis (A7XAB0), Leishmania amazonensis
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