3.4.21.83: Oligopeptidase B

This is an abbreviated version!
For detailed information about Oligopeptidase B, go to the full flat file.

Word Map on EC 3.4.21.83

3.4.21.83

gingivalis

prolyl

leupeptin

chymotrypsin-like

antipain

porphyromonas

aprotinin

chloromethyl

chymostatin

tlck

tryptase

2-macroglobulin

benzamidine

acrosin

phenylmethanesulfonyl

proteamaculans

bapna

drug development

medicine

Reaction

Hydrolysis of -Arg-/-, -Lys-/- bonds in oligopeptides, even when P1' residue is proline =

Synonyms

La_OpB, oligopeptidase B, oligopeptidase B-like, oligopeptidase B2, OP-Tb, OPB, OPB2, OPBTc, Opd B, OpdB, Protease II, Proteinase, Escherichia coli alkaline, II, PSP, Spro_3467, Tb-OP, Tc 120, Tc-OP, trypsin-like protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.83 Oligopeptidase B

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Results	in table
11	Activating Compound
5059	AA Sequence
3	Application
1	CAS Registry Number
24	Cloned(Commentary)
5	Crystallization (Commentary)
19	General Information
4	General Stability
1	IC50 Value
99	Inhibitors
86	kcat/KM [mM/s]
30	Ki Value [mM]
344	KM Value [mM]
3	Localization
5	Metals/Ions
20	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
55	Organism
9	PDB ID
17	pH Optimum
6	pH Range
3	pH Stability
2	pI Value
2	Posttranslational Modification
69	Protein Variants
16	Purification (Commentary)
1	Reaction
1	Reaction Type
51	Reference
7	Source Tissue
62	Specific Activity [micromol/min/mg]
4	Storage Stability
384	Substrates and Products (Substrate)
15	Subunits
64	Synonyms
17	Temperature Optimum [°C]
4	Temperature Range [°C]
14	Temperature Stability [°C]
332	Turnover Number [1/s]

Application

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Application on EC 3.4.21.83 - Oligopeptidase B

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drug development

Leishmania amazonensis

A7XAB0, A8QXT1

Leishmania amazonensis OPB isozymes, OPB and OPB2, can be ideal drug targets to treat leishmaniasis, since both enzymes are expressed in all parasite lifecycle and are not identified in humans

754988

medicine

2 entries