3.4.21.81: Streptogrisin B

This is an abbreviated version!
For detailed information about Streptogrisin B, go to the full flat file.

Reaction

Hydrolysis of proteins with trypsin-like specificity =

Synonyms

More, Pronase B, protease B, Proteinase B, Proteinase, Streptomyces griseus serine B, Serine proteinase B, SGPB, SprB, Streptogrisin B, Streptomyces griseus peptidase B, Streptomyces griseus protease B, Streptomyces griseus proteinase 1, Streptomyces griseus proteinase B

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.81 Streptogrisin B

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Results	in table
122	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
9	Crystallization (Commentary)
1	General Stability
12	Inhibitors
4	kcat/KM [mM/s]
9	KM Value [mM]
1	Localization
4	Molecular Weight [Da]
2	Organic Solvent Stability
26	Organism
27	PDB ID
6	pH Optimum
1	Posttranslational Modification
6	Protein Variants
5	Purification (Commentary)
1	Reaction
2	Reaction Type
25	Reference
1	Renatured (Commentary)
2	Source Tissue
27	Substrates and Products (Substrate)
3	Subunits
20	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
10	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.81 - Streptogrisin B

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

bound to wild type OMTKY3 and to the Ala32I variant, by the hanging-drop vapor-diffusion method, SGPB and OMTKY3 Ala32I forms a 1 : 2 complex in the crystal

Streptomyces griseus

-

683776

crystal structure in complex with turkey ovomucoid thir domain backbone variants OMTKY3-Pro18I and OMTKY3-psi[COO]-Leu18I

Streptomyces griseus

-

652843

crystal structure of protease B with tripeptide chloromethyl ketone inhibitors

Streptomyces griseus

-

29774

crystal structures of Leu18, Ala18, and Gly18 variants of turkey ovomucoid inhibitor third domain complexed with proteinase B

Streptomyces griseus

-

29775

structure at 2.8 A resolution

Streptomyces griseus

-

29773

structure of the complex of protease B with the third domain of the ovomucoid inhibitor from turkey at 1.8 A resolution

Streptomyces griseus

-

29769, 29770

structure of the complex of proteinase B and polypeptide chymotrypsin inhibitor-1 from Russet Burbank potato tubers at 2.1 A resolution

Streptomyces griseus

-

29767

native crystal structures at pH 4.2 at a resolution of 1.18 A, and at pH 7.3 at a resolution of 1.23 A. At pH 4.2 the enzyme is assigned as a tetrapeptide, Asp-Ala-Ile-Tyr, whereas at pH 7.3 it is assigned as a tyrosine molecule and a leucine molecule existing at equal occupancies in both of the SGPB molecules in the asymmetric unit

synthetic construct

-

697219