3.4.21.80: Streptogrisin A

This is an abbreviated version!
For detailed information about Streptogrisin A, go to the full flat file.

Reaction

Hydrolysis of proteins with specificity similar to chymotrypsin =

Synonyms

Protease A, Proteinase A, Proteinase, Streptomyces griseus serine, A, SGPA, Streptomyces griseus protease A, Streptomyces griseus proteinase A, Streptomyces griseus serine proteinase 3, Streptomyces griseus serine proteinase A

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.80 Streptogrisin A

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Results	in table
27	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
12	Crystallization (Commentary)
11	Inhibitors
10	KM Value [mM]
1	Localization
14	Organism
1	pH Optimum
1	Purification (Commentary)
1	Reaction
1	Reaction Type
14	Reference
1	Source Tissue
17	Substrates and Products (Substrate)
10	Synonyms
1	Temperature Optimum [°C]
11	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.21.80 - Streptogrisin A

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

3 acetyl-Pro-Ala-Phe-Phe-NH2 + H2O

acetyl-Pro-Ala-Phe-Phe + NH3 + acetyl-Pro-Ala + Phe-Phe-NH2 + acetyl-Pro-Ala-Phe + Phe-NH2

Streptomyces griseus

-

hydrolyzed at the Ala-Phe, the Phe-Phe and the Phe-NH2 bonds

29755

-

-

?

acetyl-Ala-Ala-Tyr-4-methylcoumarin 7-amide + H2O

acetyl-Ala-Ala-Tyr + 7-amino-4-methylcoumarin

Streptomyces griseus

-

-

29766

-

-

?

Acetyl-Pro-Ala-Ala-Phe-NH2 + H2O

?

Streptomyces griseus

-

-

29755

-

-

?

Acetyl-Pro-Ala-Gly-Phe-NH2 + H2O

?

Streptomyces griseus

-

split at amide bond as well as at the Ala-Gly bond

29755

-

-

?

Acetyl-Pro-Ala-Leu-Phe-NH2 + H2O

Acetyl-Pro-Ala-Leu-Phe-OH + NH3

Streptomyces griseus

-

hydrolyzed at the amide bond only

29755

-

-

?

Acetyl-Pro-Ala-Pro-Phe-Leu-NH2 + H2O

Acetyl-Pro-Ala-Pro-Phe + Leu-NH2

Streptomyces griseus

-

-

29759

-

29759

?

Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O

Acetyl-Pro-Ala-Pro-Phe-OH + NH3

2 entries

Acetyl-Pro-Ala-Pro-Phe-Tyr-NH2 + H2O

Acetyl-Pro-Ala-Pro-Phe + Tyr-NH2

Streptomyces griseus

-

-

29759

-

29759

?

Acetyl-Pro-Ala-Pro-Trp-NH2 + H2O

Acetyl-Pro-Ala-Pro-Trp-OH + NH3

Streptomyces griseus

-

-

29759

-

29759

?

Acetyl-Pro-Ala-Pro-Tyr-NH2 + H2O

Acetyl-Pro-Ala-Pro-Tyr-OH + NH3

Streptomyces griseus

-

-

29759

-

29759

?

Peptide + H2O

Hydrolyzed peptide + H2O

Streptomyces griseus

-

interacts favorably with peptides with hydrophobic non-aromatic, P2 amino acid residues, leucine being optimal

29755

-

-

?

succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O

succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline

Streptomyces griseus

-

-

29766

-

-

?

Succinyl-Ala-Ala-Pro-Phe-4-methylcoumarin 7-amide + H2O

?

Streptomyces griseus

-

-

29766

-

-

?

succinyl-Ala-Ala-Pro-X-4-nitroanilide + H2O

?

Streptomyces griseus

-

-

731812

-

-

?

succinyl-Ala-Ala-Pro-X-7-amido-4-methylcoumarin + H2O

?

Streptomyces griseus

-

-

731812

-

-

?

additional information

?

-

Streptomyces griseus

-

model of serine protease catalytic tetrahedral intermediates

29754

-

-

?

Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O

Acetyl-Pro-Ala-Pro-Phe-OH + NH3

Streptomyces griseus

-

-

29759

-

29759

?

Acetyl-Pro-Ala-Pro-Phe-NH2 + H2O

Acetyl-Pro-Ala-Pro-Phe-OH + NH3

Streptomyces griseus

-

hydrolyzed at the amide bond only

29755

-

29755

?