3.4.21.75: Furin
This is an abbreviated version!
For detailed information about Furin, go to the full flat file.
Word Map on EC 3.4.21.75
-
3.4.21.75
-
proproteins
-
sars-cov-2
-
covid-19
-
metalloproteinase
-
ectodomain
-
spike
-
endoprotease
-
coronavirus
-
viruses
-
trans-golgi
-
disintegrin
-
adam17
-
ace2
-
pandemic
-
tmprss2
-
neuropeptides
-
endosomes
-
neuroendocrine
-
endoproteolytic
-
propeptide
-
proinsulin
-
zymogen
-
prodomain
-
mt1-mmp
-
virion
-
anthrax
-
subtilisins
-
proglucagon
-
proopiomelanocortin
-
exotoxin
-
uncleaved
-
alpha1-antitrypsin
-
prorenin
-
baffs
-
portland
-
betacoronavirus
-
prostasin
-
secretogranin
-
alpha-amidating
-
juxtamembrane
-
pharmacology
-
sds-stable
-
medicine
-
corticotrophs
-
polybasic
-
prosegment
-
monobasic
-
drug development
-
industry
-
mers-cov
-
pcsk9
-
paramyxoviruses
-
membrane-type
-
subtilase
-
analysis
- 3.4.21.75
- proproteins
- sars-cov-2
- covid-19
- metalloproteinase
- ectodomain
- spike
- endoprotease
- coronavirus
- viruses
-
trans-golgi
-
disintegrin
- adam17
- ace2
- pandemic
- tmprss2
- neuropeptides
- endosomes
-
neuroendocrine
-
endoproteolytic
- propeptide
- proinsulin
- zymogen
- prodomain
- mt1-mmp
- virion
- anthrax
- subtilisins
- proglucagon
- proopiomelanocortin
-
exotoxin
-
uncleaved
- alpha1-antitrypsin
- prorenin
-
baffs
- portland
- betacoronavirus
- prostasin
-
secretogranin
-
alpha-amidating
-
juxtamembrane
- pharmacology
-
sds-stable
- medicine
-
corticotrophs
-
polybasic
- prosegment
-
monobasic
- drug development
- industry
- mers-cov
- pcsk9
- paramyxoviruses
-
membrane-type
-
subtilase
- analysis
Reaction
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =
Synonyms
Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin
ECTree
3.4.21.75 FurinAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.21.75 - Furin
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
-
in the digestive gland the PC1 activity of pre-breeding stage is 1.17fold and 1.55fold as that of the during-breeding and the post-breeding stages, respectively
-
PCSK3 is primarily expressed in the duodenum and the jejunum. PCSK3 is detectable in 75% of glucose-dependent insulinotropic polypeptide positive cells and 60% of substance P positive cells
additional information
-
chief cells, coordinated decrease of pepsinogen, furin, and transforming growth factor beta
-
chief cells, coordinated decrease of pepsinogen, furin, and transforming growth factor beta
-
-
relative activity of PC1 in gonad is 10% of that in the digestive gland. In male, the PC1 activity in digestive gland is slightly lower than in female
-
expression and regulation of furin in ovarian tissue, injection of equine and human chorionic gondotropin, overview
-
furin is highly expressed in placental villi during early pregnancy, specifically in trophoblast column and trophoblast shell, regions where highly invasive cytotrophoblast cells invade the maternal decidua during human placentation
proprotein convertase furin is highly expressed in syncytial trophoblast in the first trimester human placentas, and expression of furin in the syncytiotrophoblast is significantly lower in the placentas from pre-eclamptic patients as compared with their gestational age-matched control placentas
proprotein convertase furin is highly expressed in syncytial trophoblast in the first trimester human placentas, and expression of furin in the syncytiotrophoblast is significantly lower in the placentas from pre-eclamptic patients as compared with their gestational age-matched control placentas
additional information
no PCSK3 in head, ovary, and small intestine, expression in the adult, not embryo stage
additional information
-
no PCSK3 in head, ovary, and small intestine, expression in the adult, not embryo stage
additional information
-
preferentially expressed in T helper 1 cells in a Stat4-dependent manner
additional information
-
present in glucagon cells, absent from insulin cells, somatostatin cells and pancreatic polypeptide cells
additional information
-
colorectal carcinoma LoVo cell line is devoid of furin activity
additional information
cellular furin abundance in five human cell lines is shown to be strongly correlated with productive infectious bronchitis virus, IBV, infection, cells expressing furin, overview
additional information
-
cellular furin abundance in five human cell lines is shown to be strongly correlated with productive infectious bronchitis virus, IBV, infection, cells expressing furin, overview
additional information
the enzyme is constitutively expressed in all cell lines. No enzyme activity in LoVo colorectal carcinoma cells
additional information
ubiquitous expression, although furin is expressed universally, expression levels vary and can be quite low depending on tissue types
additional information
-
ubiquitous expression, although furin is expressed universally, expression levels vary and can be quite low depending on tissue types
additional information
-
furin mRNA and protein highly expressed in T helper 1 cells compared with T helper 2 cells. Stat4 binding sites in the putative promoter region (2000 bp upstream of exon 1). Also present in CD4+ T cells
additional information
-
furin is highly expressed in granulosa cells and oocytes of the ovary with very limited expression in other ovarian cells such as the epithelial, stromal or theca cells
