3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Word Map on EC 3.4.21.75

3.4.21.75

proproteins

sars-cov-2

covid-19

metalloproteinase

ectodomain

spike

endoprotease

coronavirus

viruses

trans-golgi

disintegrin

adam17

ace2

pandemic

tmprss2

neuropeptides

endosomes

neuroendocrine

endoproteolytic

propeptide

proinsulin

zymogen

prodomain

mt1-mmp

virion

anthrax

subtilisins

proglucagon

proopiomelanocortin

exotoxin

uncleaved

alpha1-antitrypsin

prorenin

baffs

portland

betacoronavirus

prostasin

secretogranin

alpha-amidating

juxtamembrane

pharmacology

sds-stable

medicine

corticotrophs

polybasic

prosegment

monobasic

drug development

industry

mers-cov

pcsk9

paramyxoviruses

membrane-type

subtilase

analysis

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

Results	in table
13	Activating Compound
214	AA Sequence
34	Application
1	CAS Registry Number
66	Cloned(Commentary)
9	Crystallization (Commentary)
2715	Disease/ Diagnostics
9	Expression
83	General Information
1	General Stability
36	IC50 Value
400	Inhibitors
65	kcat/KM [mM/s]
181	Ki Value [mM]
99	KM Value [mM]
65	Localization
35	Metals/Ions
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
506	Organism
60	PDB ID
25	pH Optimum
9	pH Range
3	pH Stability
4	Posttranslational Modification
48	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
188	Reference
136	Source Tissue
8	Specific Activity [micromol/min/mg]
7	Storage Stability
351	Substrates and Products (Substrate)
5	Subunits
119	Synonyms
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
85	Turnover Number [1/s]

3.4.21.75: Furin

Reaction

Synonyms

ECTree

Advanced search results

Organism

Organism on EC 3.4.21.75 - Furin