3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Word Map on EC 3.4.21.75

3.4.21.75

proproteins

sars-cov-2

covid-19

metalloproteinase

ectodomain

spike

endoprotease

coronavirus

viruses

trans-golgi

disintegrin

adam17

ace2

pandemic

tmprss2

neuropeptides

endosomes

neuroendocrine

endoproteolytic

propeptide

proinsulin

zymogen

prodomain

mt1-mmp

virion

anthrax

subtilisins

proglucagon

proopiomelanocortin

exotoxin

uncleaved

alpha1-antitrypsin

prorenin

baffs

portland

betacoronavirus

prostasin

secretogranin

alpha-amidating

juxtamembrane

pharmacology

sds-stable

medicine

corticotrophs

polybasic

prosegment

monobasic

drug development

industry

mers-cov

pcsk9

paramyxoviruses

membrane-type

subtilase

analysis

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.75 Furin

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Results	in table
13	Activating Compound
214	AA Sequence
34	Application
1	CAS Registry Number
66	Cloned(Commentary)
9	Crystallization (Commentary)
2715	Disease/ Diagnostics
9	Expression
83	General Information
1	General Stability
36	IC50 Value
400	Inhibitors
65	kcat/KM [mM/s]
181	Ki Value [mM]
99	KM Value [mM]
65	Localization
35	Metals/Ions
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
506	Organism
60	PDB ID
25	pH Optimum
9	pH Range
3	pH Stability
4	Posttranslational Modification
48	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
188	Reference
136	Source Tissue
8	Specific Activity [micromol/min/mg]
7	Storage Stability
351	Substrates and Products (Substrate)
5	Subunits
119	Synonyms
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
85	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.75 - Furin

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0.3

(D-Arg)6 amide

Mus musculus

IC50: 0.3 mM

667392

0.01

(D-Arg)9 amide

Mus musculus

IC50: 0.01 mM

667392

0.0037

(D-Arg)9-amide

Homo sapiens

protects RAW264.7 cells against anthrax toxemia with an IC50 of 0.0037 mM

669258

0.102

(E)-N-((E)-5-(2-chloro-5-nitrobenzylidene)-4-oxothiazolidin-2-ylidene)-4-methylbenzenesulfonamide

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.084

(N'Z,N''Z)-4,4'-oxybis(N'-(2-hydroxybenzylidene)benzenesulfonohydrazide)

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.007

2-(11-hydroxy-3-oxo-3H-dibenzo[c,h]xanthen-7-yl)benzoic acid

Homo sapiens

with CPA95 as substrate/with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.025

3'-oxo-6a,14a-dihydro-3'H-spiro[dibenzo[c,h]xanthene-7,1'-isobenzofuran]-3,11-diyl diacetate

Homo sapiens

with CPA95 as substrate

693230

0.055

3,3',3'',3'''-(1,4-phenylenebis(methanetriyl))tetrakis(4-hydroxy-2H-chromen-2-one)

Homo sapiens

with CPA95 as substrate

693230

0.004

3,3'-((2,3-dihydro-1H-inden-5-yl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Homo sapiens

with CPA95 as substrate

693230

0.02

3,3'-methylenebis(4-hydroxy-2H-chromen-2-one)

Homo sapiens

with CPA95 as substrate

693230

0.051

3-allyl-1-methyl-1,2,3,4-tetrahydroisoquinoline

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.137

3-hydroxy-5-(4-methoxyphenyl)-2-(4-phenoxy-3-sulfophenyl)-3H-pyrazol-2-ium

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.0000142

4,10-bis[(4-methylphenyl)sulfonyl]-1,2,12,13-tetradehydro-3,4,10,11-tetrahydro-5,9-(metheno)-4,10-benzodiazacyclopentadecine

Homo sapiens

710381

0.0000105

4,7-dibenzyl-1,2,9,10-tetradehydro-3,4,5,6,7,8-hexahydro-4,7-benzodiazacyclododecine

Homo sapiens

710381

0.028

6-oxo-6H-benzo[c]chromen-3-yl 2-chlorobenzoate

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.00016 - 0.000192

8,11,22,25-tetrabenzyl-5,6,13,14,19,20,27,28-octadehydro-7,8,9,10,11,12,21,22,23,24,25,26-dodecahydrodibenzo[h,t][1,4,13,16]tetraazacyclotetracosine

2 entries

0.000023

beta-Ala-TPRARRRKKRT-amide

Homo sapiens

pH 7.5, 37°C

708753

0.0077

Cu(2,2':6,2''-terpyridine)Cl2

Homo sapiens

IC50: 0.0077 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.0072

Cu(4'-hydroxo-2,2':6',2''-terpyridine)Cl2

Homo sapiens

IC50: 0.0072 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.0051

Cu(4'-[4-methoxyphenyl]-2,2':6',2''-terpyridine)Cl2

Homo sapiens

IC50: 0.0051 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.014

Cu(4,4''-dimethyl-4'-[p-tolyl]-2,2':6',2''-terpyridine)Cl2

Homo sapiens

IC50: 0.014 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.038

Cu(di-[2-picolyl]amine)Cl2

Homo sapiens

IC50: 0.038 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.014

Cu2+

Homo sapiens

IC50: 0.014 mM

669255

0.00004 - 0.000193

furin-Eda peptide acyclic

3 entries

0.000193

furin-Eda peptide cyclic

Homo sapiens

versus substrate fluorogenic peptide derived from hSARS-CoV spike protein

710381

0.002

lethal factor inhibitor 2

Mus musculus

IC50: 0.002 mM

667392

0.159

N-(benzo[d][1,3]dioxol-5-yl)-1,2,3,4-tetrahydroacridin-9-amine

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.011

N-(thiazol-2-yl)-4-(5-((2,4,6-trioxotetrahydropyrimidin-5(6H)-ylidene)methyl)furan-2-yl)benzenesulfonamide

Homo sapiens

with N-tert-butoxycarbonyl-Arg-Val-Arg-Arg-methylcoumarin amide as substrate

693230

0.002

pro-hepcidin

Mus musculus

699309

0.009

Zn(4'-[4-methoxyphenyl]-2,2':6',2''-terpyridine)Cl2

Homo sapiens

IC50: 0.009 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.009

Zn(4'-[p-tolyl]-2,2':6',2''-terpyridine)Cl2

Homo sapiens

IC50: 0.009 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.021

Zn2+

Homo sapiens

IC50: 0.021 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255

0.0069

[Cu(2,2':6,2''-terpyridine)Cl2] (OCl4)

Homo sapiens

IC50: 0.0069 mM, irreversible, competitive with substrate tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide

669255