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3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Word Map on EC 3.4.21.75

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.75 Furin

Expression

Expression on EC 3.4.21.75 - Furin

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
cytokine transforming growth factor TGF-beta stimulates furin mRNA expression in HepG2 cells
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forskolin induces the enzyme expression in choriocarcinoma cells
furin expression is detected in all rhabdomyosarcoma cell lines tested at high levels, while myoblasts and fibroblasts show low levels of furin transcripts
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furin expression is upregulated by the Th1 hallmark cytokine interleukin-12. T cell activation via T cell receptor induces furin expression
furin expression is upregulated by the Th1 hallmark cytokine interleukin-12. T-cell activation via T-cell receptor induces FURIN expression
in heaptitis C virus-infected cells, furin expression is upregulated about 3fold
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the enzyme is induced by forskolin and amphiregulin, periovulatory furin expression is also increased by human chorionic gondotropin in follicles, overview
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the enzyme is upregulated and cleaves certain substrates during hypoxia in cancer cells. In oxygen-glucose deprivation, expression of the enzyme and of brain-derived neurotrophic factor is upregulated