3.4.21.72: IgA-specific serine endopeptidase
This is an abbreviated version!
For detailed information about IgA-specific serine endopeptidase, go to the full flat file.
Word Map on EC 3.4.21.72
-
3.4.21.72
-
neisseria
-
haemophilus
-
streptococcus
-
influenzae
-
gonorrhoeae
-
hinge
-
meningitidis
-
sanguis
-
autotransporter
-
pneumococcal
-
gonococcal
-
serogroups
-
meningococci
-
oralis
-
medicine
-
protease-producing
-
lactamica
-
nontypeable
-
paraproteins
-
ramosum
-
enzyme-neutralizing
-
urealyticum
-
pharmacology
-
agriculture
-
drug development
-
analysis
- 3.4.21.72
- neisseria
- haemophilus
- streptococcus
- influenzae
- gonorrhoeae
- hinge
- meningitidis
- sanguis
-
autotransporter
- pneumococcal
-
gonococcal
-
serogroups
-
meningococci
- oralis
- medicine
-
protease-producing
- lactamica
-
nontypeable
-
paraproteins
- ramosum
-
enzyme-neutralizing
- urealyticum
- pharmacology
- agriculture
- drug development
- analysis
Reaction
Cleavage of immunoglobulin A molecules at certain Pro-/- bonds in the hinge region. No small molecule substrates are known =
Synonyms
Iga, IgA protease, IgA protease A1, IgA protease B2, IgA proteinase, IgA-specific proteinase, IgA1 protease, IgA1-protease, IgA1-specific protease, IgA1?P, IgA1P, IgA1pr, IgaA1, IgaA2, IgaB2, IgAP, Immunoglobulin A protease, Immunoglobulin A proteinase, immunoglobulin A1 protease, NMB IgA1 protease, Proteinase, immunoglobulin A, serine-type IgA1 protease, serine-type immunoglobulin A1 protease, ST-11 IgA protease, type 2 IgA1 protease
ECTree
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Substrates Products
Substrates Products on EC 3.4.21.72 - IgA-specific serine endopeptidase
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REACTION DIAGRAM
degalactosylated IgA1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
desialylated and degalactosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
desialylated/degalactosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fab
-
cleavage of the hinge region
-
-
?
immunoglobulin A1 + H2O
oligopeptides derived from immunoglobulin A1
IgA proteases only cleave the proline, serine and threonine rich hinge peptide unique to immunoglobulin A1
-
-
?
surface-exposed SD domain + H2O
?
the enzyme cleaves its own isolated recombinant SD domain, single or linked with the alpha-protein, giving the L1 domain
-
-
?
immunglobulin Fc + immunglobulin Fd
-
pathogenic human aberrantly glycosylated IgA1
-
-
?
aberrantly glycosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
pathogenic human aberrantly glycosylated immunglobulin A1
-
-
?
aberrantly glycosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
pathogenic human aberrantly glycosylated IgA1
-
-
?
aberrantly glycosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria gonorrhoeae ATCC 49226
-
pathogenic human aberrantly glycosylated IgA1
-
-
?
aberrantly glycosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
pathogenic human aberrantly glycosylated IgA1
-
-
?
aberrantly glycosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria meningitidis ATCC 13090
-
pathogenic human aberrantly glycosylated IgA1
-
-
?
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
degalactosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
desialylated and degalactosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
desialylated and degalactosylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate, high activity
-
-
?
immunglobulin Fc + immunglobulin Fd
-
artificial substrate
-
-
?
desialylated IgA1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate
-
-
?
immunglobulin Fc + immunglobulin Fd
-
artificial substrate
-
-
?
desialylated immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
artificial substrate
-
-
?
human IgA1 + H2O
?
culture supernatants from all strains tested cause degradation of human IgA1
-
-
?
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human IgA1 + H2O
?
the enzyme specifically cleaves the hinge region of human IgA1, the predominant class of immunoglobulin present on mucosal membranes
-
-
?
human IgA1 + H2O
?
unique cleavage specificity of the NTHI IgA1 protease
-
-
?
human IgA1 + H2O
?
deglycosylated human IgA1, the IgA1 protease cleaves two peptide bonds within the human IgA1 hinge region at replicate sequences, cleavage of human IgA1 produces two different sized Fc fragments with N-terminal sequence Thr-Pro-Ser-Pro-Ser
-
-
?
human IgA1 + H2O
?
-
human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease
-
-
?
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human IgA1 + H2O
?
-
human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease
-
-
?
human IgA1 + H2O
?
-
IgA1 protease is a proteolytic enzyme with strict substrate specificity for human IgA1
-
-
?
human IgA1 + H2O
?
-
the enzyme possesses a unique substrate specificity to immunoglobulin A1
-
-
?
human IgA1 + H2O
?
-
human IgA1 possesses a unique hinge region composed of a repeated sequence rich in proline, serine and threonine, which are the specific cleavage sites of IgA1 protease
-
-
?
human immunoglobulin A1 + H2O
?
bacterial isolates show wide variability in IgA1 protease activity, and those isolated from patients with clinical infection possess the highest levels of activity, overview
-
-
?
human immunoglobulin A1 + H2O
?
site-specific proteolytic cleavage
-
-
?
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
human immunoglobulin A1 + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
?
-
substrate from chang human conjunctiva cells ATCC CCL20.2, human bladder carcinoma cells RT112, JOSK-M cells, DSM ACC30, myelomonocytic cell line, HL60 cells, DSM ACC3, myelocytic cell line
-
?
human lamp-1 + H2O
?
-
substrate from chang human conjunctiva cells ATCC CCL20.2, human bladder carcinoma cells RT112, JOSK-M cells, DSM ACC30, myelomonocytic cell line, HL60 cells, DSM ACC3, myelocytic cell line
-
?
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 24% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 50% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 85% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 21% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 40% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation
-
-
?
IgA2-IgA1 half hinge + H2O
?
-
a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region, pH 7.2, 37°C, 30% of the substrate is cleaved after 24 h incubation
-
-
?
immunglobulin Fc + immunglobulin Fd
-
-
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
human IgA1, cleavage at the hinge region
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
human myeloma IgA1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
human myeloma immunglobulin A1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Haemophilus influenzae ATCC 10211
-
-
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Haemophilus influenzae ATCC 49247
-
human IgA1, cleavage at the hinge region
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Haemophilus influenzae ATCC 49247
-
-
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
cleavage of the hinge region
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
human myeloma IgA1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria gonorrhoeae ATCC 49226
-
-
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria gonorrhoeae ATCC 49226
-
human myeloma IgA1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
human myeloma IgA1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria meningitidis ATCC 13090
-
-
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
Neisseria meningitidis ATCC 13090
-
human myeloma IgA1
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
IgA1 from human serum
-
-
?
immunglobulin A1 + H2O
immunglobulin Fc + immunglobulin Fd
-
IgA1 from human serum
-
-
?
?
-
IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces
-
-
?
immunoglobulin A + H2O
?
-
IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process
-
-
?
immunoglobulin A + H2O
?
-
IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces
-
-
?
immunoglobulin A + H2O
?
-
IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process
-
-
?
immunoglobulin A + H2O
?
-
IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces
-
-
?
immunoglobulin A + H2O
?
-
IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process
-
-
?
immunoglobulin A + H2O
?
-
IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process
-
-
?
immunoglobulin A + H2O
?
-
IgA 1 proteases are a family of bacterial enzymes specifically cleaving human IgA, the immunoglobulin for antibody defense of mucosal surfaces
-
-
?
immunoglobulin A + H2O
?
-
IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process
-
-
?
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Haemophilus influenzae type 1 enzyme cleaves Pro231-Ser232, type 2 enzyme cleaves Pro235-Thr236, type 3 enzyme cleaves peptide bond 237-238
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
peptide analogs of human IgA as protease substrates
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Haemophilus influenzae enzyme has at least 2 cleavage types. Serogroups, type 1 in serotypes a, b, d, f. Type 2 in c and e
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
human myeloma immunoglobulin
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
peptide analogs of human IgA as protease substrates
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
specific for human immunoglobulin IgA1
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Neisseria gonorrhoeae cleaves peptide bond 235-236
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
human myeloma immunoglobulin
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
peptide analogs of human IgA as protease substrates
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
cleaves a Pro-Ser bond in the hinge region of the alpha1 chain between residues 223 and 224
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
specific for human immunoglobulin IgA1
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
all bacterial IgA1 proteases cleave the heavy chain of IgA1, both serum and secretory IgA2 proteins are IgA1 protease-resistant
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
Streptococcus sanguis, Streptococcus pneumoniae and Neisseria gonorrhoeae all release IgA1 proteases each cleaving a single peptide bond, Neisseria meningitidis and Haemophilus influenzae release multiple enzyme types differing in the specific peptide bonds hydrolyzed, e.g. random clinical isolates of Neisseria meningitidis release either type 1 and type 2 protease, type 1 cleaving peptide 237-238 and type 2 cleaving 235-236 in the IgA hinge
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
peptide analogs of human IgA as protease substrates
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
Immunoglobulin A + H2O
immunoglobulin Fabalpha + immunoglobulin Fc
-
-
-
-
?
?
-
pH 7.2, 37°C, 36% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 54% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 62% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 71% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
pH 7.2, 37°C, 78% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
pH 7.2, 37°C, 81% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 34% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhP227S + H2O
?
-
pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation
-
-
?
?
-
pH 7.2, 37°C, 17% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 35% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 22% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
pH 7.2, 37°C, 4% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 29% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 25% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224/230P + H2O
?
-
pH 7.2, 37°C, 31% of the substrate is cleaved after 24 h incubation
-
-
?
?
-
pH 7.2, 37°C, 19% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 67% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 41% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 51% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
pH 7.2, 37°C, 70% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
pH 7.2, 37°C, 74% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 58% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 20% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS224P + H2O
?
-
pH 7.2, 37°C, 49% of the substrate is cleaved after 24 h incubation
-
-
?
?
-
pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
-
pH 7.2, 37°C, 14% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
-
pH 7.2, 37°C, 28% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
-
pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
pH 7.2, 37°C, 3% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
pH 7.2, 37°C, 7% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
-
pH 7.2, 37°C, 27% of the substrate is cleaved after 24 h incubation
-
-
?
mutant hhS230P + H2O
?
-
pH 7.2, 37°C, 13% of the substrate is cleaved after 24 h incubation
-
-
?
?
-
specific cleavage at the C-terminal region of NF-kappaB p65/RelA component within the nucleus of infected cells
-
-
?
NF-kappaB p65/RelA component + H2O
?
-
specific cleavage at the C-terminal region of NF-kappaB p65/RelA component
-
-
?
?
-
-
in vitro studies show that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes
-
-
?
additional information
?
-
-
the type 2 IgA1 protease is a potential virulence factor in Haemophilus influenzae, the igaB encoded enzyme is the primary mediator of IgA1 protease activity in strain 11P6H, not the type 1 IgA1 protease encoded by igaA, IgA1 proteases are classified as type 1 or type 2 based on the specific site of enzymatic cleavage in the hinge region of the IgA1 molecule
-
-
?
additional information
?
-
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
-
immunglobulin A1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agimmunglobulin A1 also exists as circulating immunglobulin A1-immunglobulin G immune complexes in patients with IgAN
-
-
?
additional information
?
-
-
the IgA protease from Haemophilus influenzae strain ATCC 49247 has a high activity and the ability to degrade human in vivo deposited aberrantly glycosylated IgA1-containing immune complex
-
-
?
additional information
?
-
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated immunglobulin A1 and desialylated/degalactosylated immunglobulin A1, as compared to the wild-type immunglobulin A1 substrate, while the activity with artificial desialylated immunglobulin A1 is reduced
-
-
?
additional information
?
-
-
the enzyme performs autocatalysis at its autocleavage site
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-
?
additional information
?
-
Haemophilus influenzae ATCC 10211
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 10211
-
immunglobulin A1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agimmunglobulin A1 also exists as circulating immunglobulin A1-immunglobulin G immune complexes in patients with IgAN
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 10211
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 10211
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated immunglobulin A1 and desialylated/degalactosylated immunglobulin A1, as compared to the wild-type immunglobulin A1 substrate, while the activity with artificial desialylated immunglobulin A1 is reduced
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
the IgA protease from Haemophilus influenzae strain ATCC 49247 has a high activity and the ability to degrade human in vivo deposited aberrantly glycosylated IgA1-containing immune complex
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
the enzyme performs autocatalysis at its autocleavage site
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
immunglobulin A1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agimmunglobulin A1 also exists as circulating immunglobulin A1-immunglobulin G immune complexes in patients with IgAN
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
Haemophilus influenzae ATCC 49247
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated immunglobulin A1 and desialylated/degalactosylated immunglobulin A1, as compared to the wild-type immunglobulin A1 substrate, while the activity with artificial desialylated immunglobulin A1 is reduced
-
-
?
additional information
?
-
-
in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes
-
-
?
additional information
?
-
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
Neisseria gonorrhoeae ATCC 49226
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
Neisseria gonorrhoeae ATCC 49226
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
-
in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes
-
-
?
additional information
?
-
the NMB IgA1 protease shows a broad substrate specificity for human proteins
-
-
?
additional information
?
-
-
the NMB IgA1 protease shows a broad substrate specificity for human proteins
-
-
?
additional information
?
-
the enzyme performs autoproteolysis at the SD domain
-
-
?
additional information
?
-
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
Neisseria meningitidis ATCC 13090
-
IgA1 exists in forms of monomer, dimer, and oligomer (or polymer) in the physiological conditions and agIgA1 also exists as circulating IgA1-IgG immune complexes in patients with IgAN
-
-
?
additional information
?
-
Neisseria meningitidis ATCC 13090
-
the enzyme activity is several fold higher with artificial substrates, degalactosylated IgA1 and desialylated/degalactosylated IgA1, as compared to the wild-type IgA1 substrate, while the activity with artificial desialylated IgA1 is reduced
-
-
?
additional information
?
-
-
cleavage of p65/RelA occurs at the C-terminal region which contains the transactivation domain (TAD). Removal of the TAD from the rest of the protein may therefore disable the activation capacity of the native p65/RelA molecule
-
-
?
additional information
?
-
-
the enzyme performs autocatalysis at its autocleavage site
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
in vitro studies showed that the enzyme also cleaves human chorionic gonadotrophin hormone, granulocyte-macrophage colony stimulating factor, the CD8 surface antigen of cytotoxic T lymphocytes and LAMP 1 a membrane glycoprotein of lysosomes
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of IgA2-IgA1 half hinge, mutants hhS230P, hhS224P, hhS224/230P, hhP227S
-
-
?
additional information
?
-
-
no cleavage of mutant hhS230P
-
-
?