3.4.21.72: IgA-specific serine endopeptidase

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For detailed information about IgA-specific serine endopeptidase, go to the full flat file.

Word Map on EC 3.4.21.72

3.4.21.72

neisseria

haemophilus

streptococcus

influenzae

gonorrhoeae

hinge

meningitidis

sanguis

autotransporter

pneumococcal

gonococcal

serogroups

meningococci

oralis

medicine

protease-producing

lactamica

nontypeable

paraproteins

ramosum

enzyme-neutralizing

urealyticum

pharmacology

agriculture

drug development

analysis

Reaction

Cleavage of immunoglobulin A molecules at certain Pro-/- bonds in the hinge region. No small molecule substrates are known =

Synonyms

Iga, IgA protease, IgA protease A1, IgA protease B2, IgA proteinase, IgA-specific proteinase, IgA1 protease, IgA1-protease, IgA1-specific protease, IgA1?P, IgA1P, IgA1pr, IgaA1, IgaA2, IgaB2, IgAP, Immunoglobulin A protease, Immunoglobulin A proteinase, immunoglobulin A1 protease, NMB IgA1 protease, Proteinase, immunoglobulin A, serine-type IgA1 protease, serine-type immunoglobulin A1 protease, ST-11 IgA protease, type 2 IgA1 protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.72 IgA-specific serine endopeptidase

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Results	in table
1	Activating Compound
473	AA Sequence
31	Application
1	CAS Registry Number
26	Cloned(Commentary)
1	Crystallization (Commentary)
35	General Information
45	Inhibitors
3	KM Value [mM]
26	Localization
13	Molecular Weight [Da]
97	Natural Substrates/ Products (Substrates)
133	Organism
2	PDB ID
6	pH Optimum
1	pH Range
2	pI Value
4	Posttranslational Modification
14	Protein Variants
16	Purification (Commentary)
2	Reaction
1	Reaction Type
114	Reference
1	Renatured (Commentary)
12	Source Tissue
2	Specific Activity [micromol/min/mg]
10	Storage Stability
271	Substrates and Products (Substrate)
8	Subunits
136	Synonyms
5	Temperature Optimum [°C]
1	Temperature Stability [°C]

Purification

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Purification on EC 3.4.21.72 - IgA-specific serine endopeptidase

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4 entries

development and evaluation of a method for isolation and purification of IgA1 protease from a culture of Neisseria meningitidis serogroup A, purification involves absorption, hydrophobic interaction, anion exchange, and jacalin affinity chromatography steps, to homogeneity, overview

Neisseria meningitidis

718393

native enzyme by hydrophobic interaction chromatography, ultrafiltration, anion exchange chromatography, dialysis, gel filtration, and again ultrafiltration

3 entries

native enzyme from three inactivated intermediates of meningococcal vaccine production

Neisseria meningitidis

717322

Ni-NTA agarose column chromatography

Haemophilus influenzae

P44969

712742

recombinant extracellular His6-tagged IgA protease from Escherichia coli culture medium by nickel affinity chromatography, dialysis, and ultrafiltration, to over 95% purity

Haemophilus influenzae

754698

recombinant His-tagged enzyme variants solubilized from Escherichia coli inclusion bodies by nickel affinity chromatography, dialysis, and anion exchange chromatography

Neisseria meningitidis serogroup B

753131

recombinant His-tagged IgA1 protease by nickel affinity chromatography, anion exchange chromatography, and gel filtration

Haemophilus influenzae

P44969

717879

recombinant isolated surface-exposed SD domain from Escherichia coli to homogeneity

Neisseria meningitidis

Q0PVD3

717170

recombinant refolded enzyme solubilized from Escherichia coli inclusion bodies by ion exchange and hydrophobic interaction chromatography, followed by ultrafiltration and diafiltration

Haemophilus influenzae

753982