3.4.21.72: IgA-specific serine endopeptidase
This is an abbreviated version!
For detailed information about IgA-specific serine endopeptidase, go to the full flat file.
Word Map on EC 3.4.21.72
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3.4.21.72
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neisseria
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haemophilus
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streptococcus
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influenzae
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gonorrhoeae
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hinge
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meningitidis
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sanguis
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autotransporter
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pneumococcal
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gonococcal
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serogroups
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meningococci
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oralis
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medicine
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protease-producing
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lactamica
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nontypeable
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paraproteins
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ramosum
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enzyme-neutralizing
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urealyticum
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pharmacology
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agriculture
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drug development
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analysis
- 3.4.21.72
- neisseria
- haemophilus
- streptococcus
- influenzae
- gonorrhoeae
- hinge
- meningitidis
- sanguis
-
autotransporter
- pneumococcal
-
gonococcal
-
serogroups
-
meningococci
- oralis
- medicine
-
protease-producing
- lactamica
-
nontypeable
-
paraproteins
- ramosum
-
enzyme-neutralizing
- urealyticum
- pharmacology
- agriculture
- drug development
- analysis
Reaction
Cleavage of immunoglobulin A molecules at certain Pro-/- bonds in the hinge region. No small molecule substrates are known =
Synonyms
Iga, IgA protease, IgA protease A1, IgA protease B2, IgA proteinase, IgA-specific proteinase, IgA1 protease, IgA1-protease, IgA1-specific protease, IgA1?P, IgA1P, IgA1pr, IgaA1, IgaA2, IgaB2, IgAP, Immunoglobulin A protease, Immunoglobulin A proteinase, immunoglobulin A1 protease, NMB IgA1 protease, Proteinase, immunoglobulin A, serine-type IgA1 protease, serine-type immunoglobulin A1 protease, ST-11 IgA protease, type 2 IgA1 protease
ECTree
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Inhibitors
Inhibitors on EC 3.4.21.72 - IgA-specific serine endopeptidase
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1-(tert-butylamino)-3-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]propan-2-ol
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4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
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4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl piperidine-1-carboxylate
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4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl pyrrolidine-1-carboxylate
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4-(piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate
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4-methyl-N'-[(morpholin-4-ylcarbonyl)oxy]benzenecarboximidamide
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methyl 3-[([[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]acetyl)amino]benzoate
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N-(1,3-benzodioxol-5-yl)-2-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]acetamide
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N-cyclopentyl-2-[[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy]acetamide
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no inhibition by natural protease inhibitors SLPI, alpha-1-antitrypsin, cathepsin G and cystatin C, and by synthetic protease inhibitors Tos-Lys-chloromethylketone, and ZD0892
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additional information
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no inhibition by natural protease inhibitors SLPI, alpha-1-antitrypsin, cathepsin G and cystatin C, and by synthetic protease inhibitors Tos-Lys-chloromethylketone, and ZD0892
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additional information
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detection of small molecule, nonpeptidic inhibitors of Haemophilus influenzae IgA1 proteases, inhibitor screening and structure-activity relationship analysis. Improved inhibition and selectivity for IgA protease over other serine proteases
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