3.4.21.71: Pancreatic elastase II
This is an abbreviated version!
For detailed information about Pancreatic elastase II, go to the full flat file.
Word Map on EC 3.4.21.71
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3.4.21.71
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neutropenia
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ii-forming
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chymostatin
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netherton
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proelastase
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kostmann
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chymostatin-sensitive
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tetradecapeptide
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1-protease
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elastolytic
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ii-generating
- 3.4.21.71
- neutropenia
-
ii-forming
- chymostatin
- netherton
-
proelastase
-
kostmann
-
chymostatin-sensitive
- tetradecapeptide
-
1-protease
-
elastolytic
-
ii-generating
Reaction
Preferential cleavage: Leu-/-, Met-/- and Phe-/-. Hydrolyses elastin =
Synonyms
bovine pancreatic elastase, ELA-2, ELA2, Elastase 2, elastase-2, GICP, neutrophil elastase 2
ECTree
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General Information
General Information on EC 3.4.21.71 - Pancreatic elastase II
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physiological function
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elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome
physiological function
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elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome. Transgenic elastase 2 mice display an ichthyotic phenotype
physiological function
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expression of ELA2 is associated with histone acetylation in leukemic cell lines. DNA methylation and transcript levels of ELA2 in chronic myeloid leukemia are not correlated
physiological function
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the enzyme's biological functions include involvement in migration of neutrophils by means of focal proteolysis, killing of microorganisms, and degradation/activation of various proteins including cytokines, chemokines and ECM proteins
physiological function
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the enzyme plays a role in the maintenance of basal hemodynamics, contributing to cardiovascular homeostasis. The enzyme acts on the sympathovagal balance of the heart