3.4.21.7: plasmin
This is an abbreviated version!
For detailed information about plasmin, go to the full flat file.
Word Map on EC 3.4.21.7
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3.4.21.7
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fibrinolysis
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fibrinogen
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urokinase
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coagulation
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clot
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tissue-type
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thrombin
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pai-1
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endothelial
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urokinase-type
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artery
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platelet
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upa
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thrombosis
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thrombolytic
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antithrombin
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streptokinase
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heparin
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inhibitor-1
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bleeding
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infarct
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kringle
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prothrombin
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coronary
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venous
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hemorrhage
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d-dimers
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kallikrein
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anticoagulant
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stroke
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hemostatic
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zymogen
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thromboembolic
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zymography
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intravascular
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thromboplastin
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aprotinin
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2-macroglobulin
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amidolytic
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thrombin-antithrombin
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hypercoagulable
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tranexamic
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lipoproteina
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procoagulant
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antifibrinolytic
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recanalization
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prekallikrein
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alteplase
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fibrinopeptide
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nutrition
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analysis
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medicine
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degradation
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pharmacology
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thrombophilia
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agriculture
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food industry
- 3.4.21.7
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fibrinolysis
- fibrinogen
- urokinase
- coagulation
- clot
-
tissue-type
- thrombin
- pai-1
- endothelial
-
urokinase-type
- artery
- platelet
- upa
- thrombosis
-
thrombolytic
- antithrombin
- streptokinase
- heparin
- inhibitor-1
- bleeding
- infarct
-
kringle
- prothrombin
- coronary
- venous
- hemorrhage
-
d-dimers
- kallikrein
-
anticoagulant
- stroke
-
hemostatic
- zymogen
-
thromboembolic
-
zymography
-
intravascular
- thromboplastin
- aprotinin
-
2-macroglobulin
-
amidolytic
-
thrombin-antithrombin
-
hypercoagulable
-
tranexamic
-
lipoproteina
-
procoagulant
-
antifibrinolytic
-
recanalization
- prekallikrein
- alteplase
-
fibrinopeptide
- nutrition
- analysis
- medicine
- degradation
- pharmacology
- thrombophilia
- agriculture
- food industry
Reaction
Preferential cleavage: Lys-/- > Arg-/-; higher selectivity than trypsin. Converts fibrin into soluble products =
Synonyms
actase, delta-plasmin, EC 3.4.4.14, fibrinase, fibrinolysin, More, mu-plasmin, mu-plasminogen, PL, plasmin, plasminogen, PLG, Plm, PLS, serum tryptase, thrombolysin
ECTree
3.4.21.7 plasminAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.21.7 - plasmin
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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plasmin is generated by the plasmin/u-PA system on surfaces of A-549 alveolar lining cells
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plasmin evokes an increase in both phosphoinositide hydrolysis and Fura-2/AM fluorescence in cultured cortical astrocytes. Plasmin activiates extracellular signal-regulated kinase and induces a rise in intracellular Ca2+ concentration and phopho-ERK1/2 levels
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plasmin has no effect on ERK1/2 signaling or Ca2+ concentraion in primary cultured hippocampal neurons or hippocampal slices
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plasmin induces scattering of HT-29-M6 cells in the presence of 12-myristate 13-acetate
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plasmin induces a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations
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leukaemic cell line. In L5178Y cells with knock-out of the gene for annexin A2, the mRNA level of plasminogen is not substantially changed, but the protein level of plasmin is significantly lowered. mRNA and protein levels of S100A10 and fascin are lower in annexin A2 knock-out cells than in wild-type L5178Y cells
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plasmin triggers expression and release of proinflammatory cytokines such as TNF-alpha and IL-6 in human monocyte-derived macrophages with a somewhat lower potency than the standard stimulus lipopolysaccharide. Plasmin-induced activation of JAK1, p38, ERK1/2, and NF-kappaB is indispensable for the cytokine expression
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in CA1 pyramidal neuron, plasmin application potentiates the N-methyl-D-aspartate receptor-dependent component of miniature excitatory postsynaptic currents recorded from CA1 pyramidal neurons but has no effect on -amino-3-hydroxy-5-methyl-4-isoxazole propionate- or -aminobutyric acid receptor-mediated synaptic currents. Plasmin also increased N-methyl-D-aspartate-induced whole cell receptor currents recorded from CA1 pyramidal cells
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steroid-treated ovariectomized mice deficient in tissue inhibitor of metalloprotease-1 and exposed to estrogen show a significant increase in plasmin activity. Increase is probably due to reduced expression of plasmin inhibitors serpinb7 and serpinb2
additional information
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plasma obtained from coronary artery disease patients contains 1.7fold more plasmin compared to controls
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plasmin activity and alpha1-antitrypsin activity increase with age with a direct correlation between body mass index and elastase and plasmin activity, and alpha1-antitrypsin concentration. Plasmin and elastase activity and cholesterol concentration inversely correlate with trypsin activity and matrix metalloproteinase-9 concentration
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vitreous from patients with proliferative vitreoretinopathy have readily detectable levels of plasmin. Presence of plasmin is not unique to patients with proliferative vitreoretinopathy, but also present in a patient undergoing retinal surgery unrelated to proliferative vitreoretinopathy
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normal eyes have a low, albeit detectable, level of plasmin. Levels of plasmin are higher in eyes from rabbits with proliferative vitreoretinopathy. Amounts correlate with the stage of proliferative vitreoretinopathy
additional information
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high level of plasmin activity in high electrolyte ratio breast cysts, which have a low risk for cancer development
additional information
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in PC-3 cells, processing of pro-brain-derived neurotrophic factor by plasmin occurs in the pericellular environment
additional information
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plasmin is abundant in human atherosclerotic lesions, where it colocalizes with dendritic cells
additional information
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in PCAEC cells, plasmin induces an endothelium-dependent relaxation and a concentration-dependent transient elevation in the cytosolic Ca2+ concentrations. Plasmin concentration-dependently induces NO production
