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3.4.21.7: plasmin

This is an abbreviated version!
For detailed information about plasmin, go to the full flat file.

Word Map on EC 3.4.21.7

Reaction

Preferential cleavage: Lys-/- > Arg-/-; higher selectivity than trypsin. Converts fibrin into soluble products =

Synonyms

actase, delta-plasmin, EC 3.4.4.14, fibrinase, fibrinolysin, More, mu-plasmin, mu-plasminogen, PL, plasmin, plasminogen, PLG, Plm, PLS, serum tryptase, thrombolysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.7 plasmin

KI Value

KI Value on EC 3.4.21.7 - plasmin

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.051 - 0.061
4-aminobenzamidine
1.074 - 1.408
4-aminomethylbenzamidine
0.292 - 0.301
4-carboxybenzamidine
0.0057
479-504 peptide of factor VIII
-
-
-
0.0103
484-509 peptide of factor VIII
-
-
-
0.0628
489-514 peptide of factor VIII
-
-
-
0.0068 - 0.0113
6-aminohexanoic acid
0.0000038
Aedes aegypti trypsin inhibitor
pH and temperature not specified in the publication
-
0.000081
amyloid precursor-like protein 2
pH and temperature not specified in the publication
-
0.00000018
Aprotinin
pH and temperature not specified in the publication
0.00000156
bdellin
pH and temperature not specified in the publication
-
0.032 - 0.161
benzamidine
0.002
bikazin salivary inhibitor
pH and temperature not specified in the publication
-
0.0001
bikunin
pH and temperature not specified in the publication
-
0.000127
chicken liver trypsin inhibitor
pH and temperature not specified in the publication
-
0.0000022
CU-2010
pH and temperature not specified in the publication
-
0.00057
D-Ile-Phe-Lys-CH2Cl
pH and temperature not specified in the publication
0.000000087
DX-1000
pH and temperature not specified in the publication
-
0.0038
fibrinogen
-
-
-
0.0095
fragment X
-
-
-
0.0000227
human aprotinin analogue
-
compared with recombinant-aprotinin, the Ki of the human aprotinin analogue is found to increase by about 2.6fold, suggesting that the substitution of Arg17-Ile18 with Lys17-Met18 in aprotinin somehow impair its interaction with plasmin
-
0.0000011
infestin
pH and temperature not specified in the publication
-
0.0000009
KD1-L17R
pH and temperature not specified in the publication
-
0.0000031
KM(O2)YR-H
pH and temperature not specified in the publication
0.00000104
Kunitz-type inhibitor 2
pH and temperature not specified in the publication
-
0.000027
LEKTI
-
-
0.00000032
Leucaena-type trypsin inhibitor
pH and temperature not specified in the publication
-
0.0000031
Lys-Met(sulfone)-Tyr-Arg
-
pH 8.0, 22°C
0.0000075
natural aprotinin
-
-
-
0.000042
nexin 2
pH and temperature not specified in the publication
-
0.00033
ONO-3307
pH and temperature not specified in the publication
0.0022 - 0.004
Pentamidine
0.00000049
plasminostreptin
pH and temperature not specified in the publication
-
0.00015
Protein C inhibitor
-
37°C
-
0.0000086
recombinant aprotinin
-
-
-
0.000028
RG1192
-
pH 7.4, 37°C
-
0.00011
RG1503
-
pH 7.4, 37°C
-
0.0002 - 0.0025
stearate
0.000055
TdPI tryptase inhibitor
pH and temperature not specified in the publication
-
0.0000035
textilinin-1
-
0.000026
tissue factor pathway inhibitor-1
pH and temperature not specified in the publication
-
0.00001
tissue factor pathway inhibitor-2
pH and temperature not specified in the publication
-