Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

3.4.21.68: t-Plasminogen activator

This is an abbreviated version!
For detailed information about t-Plasminogen activator, go to the full flat file.

Word Map on EC 3.4.21.68

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.68 t-Plasminogen activator

Turnover Number

Turnover Number on EC 3.4.21.68 - t-Plasminogen activator

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.099 - 6.08
(p-F)-FPRANSNH-C2H5
0.24
acetyl-FTAR-4-nitroanilide
pH and temperature not specified in the publication
0.86
acetyl-FYAR-4-nitroanilide
pH and temperature not specified in the publication
0.36
acetyl-GTAR-4-nitroanilide
pH and temperature not specified in the publication
0.21
acetyl-GTGR-4-nitroanilide
pH and temperature not specified in the publication
0.46
acetyl-QYAR-4-nitroanilide
pH and temperature not specified in the publication
0.11 - 6.08
Boc-(p-F)-FPRANSNH-C2H5
0.01 - 4.7
Boc-D-FLRANSNH-C3H7
0.017 - 0.15
Boc-D-FPRANSNH-C6H11
7.9
Boc-D-FVR-ANSNH-C2H5
-
pH 7.4, 25°C, ratio tc/sc
0.019 - 0.49
Boc-D-FVRANSNH-C2H5
0.012 - 3.3
Boc-D-LGRANSNH-C6H11
0.038 - 6.08
Boc-D-LPRANSNH-C3H7
0.022 - 6.08
Boc-D-LSRANSNH-C3H7
0.036 - 5
Boc-D-VGRANSNH-C4H9
0.065 - 3.8
Boc-D-VPRANSNH-C4H9
0.084
Boc-L-VGRANSNHC4H9
-
pH 7.4, 25°C
0.018
D-FLRANSNH-C3H7
-
pH 7.4, 25°C, tc-tPA
0.016
D-FPR-ANSNH-C6H11
-
pH 7.4, 25°C, sc-tPA
0.45
D-FPR-ANSNH-C6H5CH2
-
pH 7.4, 25°C, sc-tPA
0.47
D-FPR-ANSNH-n-C4H9
-
pH 7.4, 25°C, tc-tPA
3.3 - 3.6
D-FPR-ANSNH-n-C6H13
3.8
D-FPR-ANSNH-t-C4H9
-
pH 7.4, 25°C, ratio tc/sc
0.51 - 6.08
D-FPR-ANSNHC6H11
0.13 - 1.7
D-FPRANSN-(CH2)6
0.09 - 1.6
D-FPRANSN-C2H5-C2H5
0.15
D-FPRANSN-H-c-C6H11
-
pH 7.4, 25°C, sc-tPA
0.2
D-FPRANSN-H-i-C3H7
-
pH 7.4, 25°C, tc-tPA
0.25 - 6.08
D-FPRANSN-H-t-C4H9
0.32 - 2.1
D-FPRANSNH-c-C6H11
0.27 - 6.08
D-FPRANSNH-C2H4OCH3
32
D-FPRANSNH-C6H11
-
pH 7.4, 25°C, ratio tc/sc
0.54 - 6.08
D-FPRANSNH-C6H5CH2
0.083 - 1.8
D-FPRANSNH-CH2COOCH3
0.29 - 6.08
D-FPRANSNH-i-C3H7
0.33 - 1.4
D-FPRANSNH-n-C4H9
1.1
D-FPRANSNH-n-C6H13
-
pH 7.4, 25°C, sc-tPA
0.025
D-FVR-ANSNH-C2H5
-
pH 7.4, 25°C, tc-tPA
0.011 - 2.3
D-FVRANSNH-C2H5
0.026 - 10.7
D-Ile-Pro-Arg-p-nitroanilide
0.034 - 4
D-LGR-ANSNH-C6H11
0.0084 - 0.057
D-LGRANSNH-C6H11
0.061 - 2.8
D-LPRANSNH-C3H7
0.019 - 5.3
D-LSRANSNH-C3H7
89
D-LSRANSNHC3H7
-
pH 7.4, 25°C
0.021 - 9
D-VGRANSNH-C4H9
0.059 - 2.7
D-VPRANSNH-C4H9
0.04
L-FPRANSNH-C2H5
-
pH 7.4, 25°C
0.08
L-VGRANSNH-C4H9
-
pH 7.4, 25°C
0.009
Lys-Lys-Cys-Pro-Gly-Arg-Val-Val-Gly-Gly-Cys-Val-Ala-His
-
-
0.0012
Lys-Lys-Ser-Pro-Gly-Arg-Val-Val-Gly-Gly-Ser-Val-Ala-His
-
-
0.0005 - 0.21
Lys-plasminogen
-
0.0025 - 0.4718
plasminogen
-
2 - 60
spectrozyme tPA
0.0041
[SNase]-PFGRSA
-
pH 7.4, 37°C
-
0.018
[SNase]-PFGRSAG
-
pH 7.4, 37°C
-
0.0075
[SNase]-PGPFGRSAG
-
pH 7.4, 37°C
-
0.01
[SNase]-PGPFGRSAGG
-
pH 7.4, 37°C
-
0.012
[SNase]-PHYGRSGG
-
pH 7.4, 37°C
-
0.011
[SNase]-PPFGRSAG
-
pH 7.4, 37°C
-
0.006
[SNase]-PQRGRSAG
-
pH 7.4, 37°C
-
additional information
additional information
-
-
-