3.4.21.68: t-Plasminogen activator

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For detailed information about t-Plasminogen activator, go to the full flat file.

Word Map on EC 3.4.21.68

3.4.21.68

pai-1

stroke

inhibitor-1

artery

thrombolysis

fibrinolysis

endothelial

infarct

phorbol

hemorrhage

urokinase

fibrin

coronary

clot

myocardial

coagulation

cerebral

12-o-tetradecanoylphorbol-13-acetate

fibrinogen

occlusion

bleeding

platelet

reperfusion

heparin

venous

pkc

urokinase-type

upa

13-acetate

anticoagulant

embolism

thrombus

intracranial

willebrand

angiography

thrombotic

recanalization

streptokinase

hemostatic

prothrombin

d-dimers

thromboembolic

patency

endovascular

intra-arterial

antithrombin

angioplasty

thrombomodulin

prothrombotic

hypercoagulable

drug development

diagnostics

medicine

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.68 t-Plasminogen activator

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Results	in table
36	Activating Compound
1259	AA Sequence
47	Application
1	CAS Registry Number
41	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
75764	Disease/ Diagnostics
11	Expression
59	General Information
27	IC50 Value
118	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
210	KM Value [mM]
15	Localization
32	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
965	Organism
15	PDB ID
11	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
49	Protein Variants
20	Purification (Commentary)
1	Reaction
3	Reaction Type
155	Reference
164	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
224	Substrates and Products (Substrate)
19	Subunits
261	Synonyms
14	Temperature Optimum [°C]
4	Temperature Stability [°C]
185	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.68 - t-Plasminogen activator

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147000