3.4.21.68: t-Plasminogen activator

This is an abbreviated version!
For detailed information about t-Plasminogen activator, go to the full flat file.

Reaction

Specific cleavage of Arg-/-Val bond in plasminogen to form plasmin =

Synonyms

Alteplase, BAT-PA, desmoteplase, DSPA beta, DSPA gamma, EC 3.4.21.31, EC 3.4.99.26, human tissue-type plasminogen activator, IV t-PA, IV tissue plasminogen activator, More, plasminogen activator, Plasminogen activator, tissue-type, PLAT, r-tPA, recombinant tissue plasminogen activator, Reteplase, rt-PA, rtPA, sc-tPA, sctPA, single chain enzyme tPA, t-PA, t-PA protein, t-plasminogen activator, tc-tPA, tctPA, Tissue plasminogen activator, tissue type plasminogen activator, tissue-plasminogen activator, Tissue-type plasminogen activator, tissue-type plasmiongen activator, tPA, two chain tPA

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.68 t-Plasminogen activator

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
36	Activating Compound
1259	AA Sequence
47	Application
1	CAS Registry Number
41	Cloned(Commentary)
1	Cofactor
5	Crystallization (Commentary)
75764	Disease/ Diagnostics
11	Expression
59	General Information
27	IC50 Value
118	Inhibitors
5	kcat/KM [mM/s]
6	Ki Value [mM]
210	KM Value [mM]
15	Localization
32	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
965	Organism
15	PDB ID
11	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
49	Protein Variants
20	Purification (Commentary)
1	Reaction
3	Reaction Type
155	Reference
164	Source Tissue
9	Specific Activity [micromol/min/mg]
2	Storage Stability
224	Substrates and Products (Substrate)
19	Subunits
261	Synonyms
14	Temperature Optimum [°C]
4	Temperature Stability [°C]
185	Turnover Number [1/s]

Cofactor

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Cofactor on EC 3.4.21.68 - t-Plasminogen activator

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Cofactor Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Homo sapiens

-

native and recombinant beta2-glycoprotein I or its domain V stimulate tPA-dependent plasminogen activation in a concentration-dependent manner. Beta2-glycoprotein I binds tPA with high affinity (Kd =20 nmol), stimulates tPA amidolytic activity, and causes an overall 20fold increase in the catalytic efficiency (kcat/Km) of tPA-mediated conversion of Glu-plasminogen to plasmin

695959

-