3.4.21.64: peptidase K
This is an abbreviated version!
For detailed information about peptidase K, go to the full flat file.
Word Map on EC 3.4.21.64
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3.4.21.64
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3.4.21.4
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chymotrypsin
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subtilisins
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alpha-chymotrypsin
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carlsberg
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3.1.1.3
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synthesis
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degradation
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beta-trypsin
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diagnostics
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analysis
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pharmacology
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molecular biology
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medicine
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detergent
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3.4.17.1
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biotechnology
- 3.4.21.64
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3.4.21.4
- chymotrypsin
- subtilisins
- alpha-chymotrypsin
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carlsberg
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3.1.1.3
- synthesis
- degradation
- beta-trypsin
- diagnostics
- analysis
- pharmacology
- molecular biology
- medicine
- detergent
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3.4.17.1
- biotechnology
Reaction
Hydrolysis of keratin, and of other proteins with subtilisin-like specificity. Hydrolyses peptide amides =
Synonyms
EC 3.4.21.14, EC 3.4.21.4, EC 3.4.4.16, endopeptidase K, mesophilic proteinase K, PROK, Proteinase K, Proteinase, Tritirachium album serine, Tritirachium album proteinase K, Tritirachium alkaline proteinase
ECTree
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Reference on EC 3.4.21.64 - peptidase K
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Betzel, C.; Teplyakov, A.V.; Harutyunyan, E.H.; Saenger, W.; Wilson, K.S.
Thermitase and proteinase K: a comparison of the refined three-dimensional structures of the native enzymes
Protein Eng.
3
161-172
1990
Parengyodontium album
Ebeling, W.; Hennrich, N.; Klockow, M.; Metz, H.; Orth, H.D.; Lang, H.
Proteinase K from Tritirachium album Limber
Eur. J. Biochem.
47
91-97
1974
Parengyodontium album
Morihara, K.; Tsuzuki, H.
Specificity of proteinase K from Tritirachium album Limber for synthetic peptides
Agric. Biol. Chem.
39
1489-1492
1975
Parengyodontium album
-
Kraus, E.; Kiltz, H.H.; Femfert, U.F.
The specificity of proteinase K against oxidized insulin B chain
Hoppe-Seyler's Z. Physiol. Chem.
357
233-237
1976
Parengyodontium album
Jany, K.D.; Lederer, G.; Mayer, B.
Amino acid sequence of proteinase K from the mold Tritirachium album Limber
FEBS Lett.
199
139-144
1986
Parengyodontium album
-
Hilz, H.; Wiegers, U.; Adamietz, P.
Stimulation of proteinase K action by denaturing agents: application to the isolation of nucleic acids and the degradation of masked proteins
Eur. J. Biochem.
56
103-108
1975
Parengyodontium album
Dattagupta, J.K.; Fujiwara, T.; Grishin, E.V.; Lindner, K.; Manor, P.C.; Pieniazek, N.J.; Saenger, W.; Suck, D.
Crystallization of the fungal enzyme proteinase K and amino acid composition
J. Mol. Biol.
97
267-271
1975
Parengyodontium album
Hilz, H.; Fanick, W.
Divergent denaturation of proteases by urea and dodecylsulfate in the absence of substrate
Hoppe-Seyler's Z. Physiol. Chem.
359
1447-1450
1978
Parengyodontium album
Pellegrini, A.; Hägeli, G.; von Fellenberg, R.
Isolation and characterization of two new low-molecular-weight protein proteinase inhibitors from the granule-rich fraction of equine neutrophilic granulocytes
Biochim. Biophys. Acta
952
309-316
1988
Parengyodontium album
Bajorath, J.; Hinrichs, W.; Saenger, W.
The enzymatic activity of proteinase K is controlled by calcium
Eur. J. Biochem.
176
441-447
1988
Parengyodontium album
Betzel, C.; Pal, G.P.; Saenger, W.
Three-dimensional structure of proteinase K at 0.15-nm resolution
Eur. J. Biochem.
178
155-171
1988
Parengyodontium album
Ardelt, W.; Laskowski, M.
Turkey ovomucoid third domain inhibits eight different serine proteinases of varied specificity on the same ...Leu18-Glu19 ... reactive site
Biochemistry
24
5313-5320
1985
Parengyodontium album
Betzel, C.; Pal, G.P.; Struck, M.; Jany, K.D.; Saenger, W.
Active-site geometry of proteinase K. Crystallographic study of its complex with a dipeptide chloromethyl ketone inhibitor
FEBS Lett.
197
105-110
1986
Parengyodontium album
Pähler, A.; Banerjee, A.; Dattagupta, J.K.; Fujiwara, T.; Lindner, K.; Pal, G.P.; Suck, D.; Weber, G.; Saenger, W.
Three-dimensional structure of fungal proteinase K reveals similarity to bacterial subtilisin
EMBO J.
3
1311-1314
1984
Parengyodontium album
Muller, A.; Hinrichs, W.; Wolf, W.M.; Saenger, W.
Crystal structure of calcium-free proteinase K at 1.5-A resolution
J. Biol. Chem.
269
23108-23111
1994
Parengyodontium album
Betzel, C.; Singh, T.P.; Visanji, M.; Peters, K.; Fittkau, S.; Saenger, W.; Wilson, K.S.
Structure of the complex of proteinase K with a substrate analogue hexapeptide inhibitor at 2.2-A resolution
J. Biol. Chem.
268
15854-15858
1993
Parengyodontium album
Segal, D.; Shalitin, Y.; Wingert, H.; Kitamura, T.; Stang, P.J.
The interaction of alkynyl carboxylates with serine enzymes. A potent new class of serine enzyme inhibitors
FEBS Lett.
247
217-220
1989
Parengyodontium album
Jany, K.D.; Nitsche, E.
Limited proteolysis of glucose dehydrogenase from Bacillus megaterium by proteinase K
Hoppe-Seyler's Z. Physiol. Chem.
364
839-844
1983
Parengyodontium album
Pal, G.P.; Kavounis, C.A.; Jany, K.D.; Tsernoglou, D.
The three-dimensional structure of the complex of proteinase K with its naturally occurring protein inhibitor, PKI3
FEBS Lett.
341
167-170
1994
Parengyodontium album
Zemke, K.J.; Muller-Fahrnow, A.; Jany, K.D.; Pal, G.P.; Saenger, W.
The three-dimensional structure of the bifunctional proteinase K/alpha-amylase inhibitor from wheat (PK13) at 2.5 A resolution
FEBS Lett.
279
240-242
1991
Triticum aestivum
Bajorath, J.; Raghunathan, S.; Hinrichs, W.; Saenger, W.
Long-range structural changes in proteinase K triggered by calcium ion removal
Nature
337
481-484
1989
Parengyodontium album
Okotore, R.O.; Uhlenbruck, G.
Proteinase inhibitors in albumin glands of Achatina fulica
Z. Naturforsch. C
37
142-144
1982
Parengyodontium album
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Orstan, A.; Gafni, A.
Inhibition of proteinase K by phosphorylated sugars
Biochem. Int.
25
657-662
1991
Parengyodontium album
Uhlenbruck, G.; Sprenger, I.; Ishiyama, I.
A new polyvalent proteinase-inhibitor occurring in the albumin gland of Helix pomatia
Z. Klin. Chem. Klin. Biochem.
9
361-362
1971
Parengyodontium album
Sprenger, I.; Uhlenbruck, G.; Hermann, G.
Snail albumin gland: a new source of proteinase inhibitors
Enzymologia
43
83-88
1972
Parengyodontium album
Deepthi, S.; Venkatesh, R.; Sundaram, P.V.
Catalytic efficiency of covalently modified proteases against proteinaceous substrates
Ann. N. Y. Acad. Sci.
864
521-523
1998
Tritirachium album Limber
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Betzel, C.; Gourinath, S.; Kumar, P.; Kaur, P.; Perbandt, M.; Eschenburg, S.; Singh, T.P.
Structure of a serine protease proteinase K from Tritirachium album limber at 0.98 A resolution
Biochemistry
40
3080-3088
2001
Tritirachium album Limber
Koeditz, J.; Arnold, U.; Ulbrich-Hofmann, R.
Dissecting the effect of trifluoroethanol on ribonuclease A: subtle structural changes detected by nonspecific proteases
Eur. J. Biochem.
269
3831-3837
2002
Tritirachium album Limber
Leydier, C.; Andersen, J.S.; Couthon, F.; Forest, E.; Marcillat, O.; Denoroy, L.; Vial, C.; Clottes, E.
Proteinase K processing of rabbit muscle creatine kinase
J. Protein Chem.
16
67-74
1997
Tritirachium album Limber
Singh, R.K.; Gourinath, S.; Sharma, S.; Roy, I.; Gupta, M.N.; Betzel, C.; Srinivasan, A.; Singh, T.P.
Enhancement of enzyme activity through three-phase partitioning: crystal structure of a modified serine proteinase at 1.5 A resolution
Protein Eng.
14
307-313
2001
Tritirachium album Limber
Singh, T.P.; Sharma, S.; Karthikeyan, S.; Betzel, C.; Bhatia, K.L.
Crystal structure of a complex formed between proteolytically-generated lactoferrin fragment and proteinase K
Proteins Struct. Funct. Genet.
33
30-38
1998
Tritirachium album Limber
Gupta, M.N.; Tyagi, R.; Sharma, S.; Karthikeyan, S.; Singh, T.P.
Enhancement of catalytic efficiency of enzymes through exposure to anhydrous organic solvent at 70 DegC. Three-dimensional structure of a treated serine proteinase at 2.2.ANG. resolution
Proteins Struct. Funct. Genet.
39
226-234
2000
Tritirachium album Limber
Georgieva, D.; Rypniewski, W.; Echner, H.; Perbandt, M.; Koker, M.; Clos, J.; Redecke, L.; Bredehorst, R.; Voelter, W.; Genov, N.; Betzel, C.
Synthetic human prion protein octapeptide repeat binds to the proteinase K active site
Biochem. Biophys. Res. Commun.
325
1406-1411
2004
Parengyodontium album
Yamashita, K.; Kikkawa, Y.; Kurokawa, K.; Doi, Y.
Enzymatic degradation of poly(L-lactide) film by proteinase K: quartz crystal microbalance and atomic force microscopy study
Biomacromolecules
6
850-857
2005
Komagataella pastoris
Larsen, A.N.; Moe, E.; Helland, R.; Gjellesvik, D.R.; Willassen, N.P.
Characterization of a recombinantly expressed proteinase K-like enzyme from a psychrotrophic Serratia sp
FEBS J.
273
47-60
2006
Serratia sp., Parengyodontium album
Stone, L.A.; Jackson, G.S.; Collinge, J.; Wadsworth, J.D.; Clarke, A.R.
Inhibition of proteinase K activity by copper(II) ions
Biochemistry
46
245-252
2007
Tritirachium album Limber
Slovakova, M.; Peyrin, J.M.; Bilkova, Z.; Juklickova, M.; Hernychova, L.; Viovy, J.L.
Magnetic proteinase K reactor as a new tool for reproducible limited protein digestion
Bioconjug. Chem.
19
966-972
2008
Parengyodontium album
Liao, J.; Warmuth, M.K.; Govindarajan, S.; Ness, J.E.; Wang, R.P.; Gustafsson, C.; Minshull, J.
Engineering proteinase K using machine learning and synthetic genes
BMC Biotechnol.
7
16
2007
Parengyodontium album
Gardberg, A.S.; Blakeley, M.P.; Myles, D.A.
A preliminary neutron crystallographic study of proteinase K at pD 6.5
Acta Crystallogr. Sect. F
65
184-187
2009
Parengyodontium album (P06873)
Larson, S.B.; Day, J.S.; Nguyen, C.; Cudney, R.; McPherson, A.
High-resolution structure of proteinase K cocrystallized with digalacturonic acid
Acta Crystallogr. Sect. F
65
192-198
2009
Parengyodontium album (P06873)
Cronier, S.; Gros, N.; Tattum, M.H.; Jackson, G.S.; Clarke, A.R.; Collinge, J.; Wadsworth, J.D.
Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
Biochem. J.
416
297-305
2008
Parengyodontium album
Kore, A.R.; Shanmugasundaram, M.; Hoang, Q.; Kuo, M.; Chapman, L.M.; Chen, H.H.
Synthesis and application of MeOSuc-Ala-Ala-Pro-Phe-CH2Cl as potent proteinase K inhibitor
Bioorg. Med. Chem. Lett.
19
1296-1300
2009
Parengyodontium album (P06873)
Tomar, R.; Dubey, V.K.; Jagannadham, M.V.
Effect of alkyl alcohols on partially unfolded state of proteinase K: Differential stability of alpha-helix and beta-sheet rich regions of the enzyme
Biochimie
91
951-960
2009
Parengyodontium album
Liu, S.; Meng, Z.; Fu, Y.; Zhang, K.
Insights derived from molecular dynamics simulation into the molecular motions of serine protease proteinase K
J. Mol. Model.
16
17-28
2010
Parengyodontium album
Liu, S.Q.; Tao, Y.; Meng, Z.H.; Fu, Y.X.; Zhang, K.Q.
The effect of calciums on molecular motions of proteinase K
J. Mol. Model.
17
289-300
2011
Parengyodontium album
Zauner, G.; Koeleman, C.A.; Deelder, A.M.; Wuhrer, M.
Protein glycosylation analysis by HILIC-LC-MS of Proteinase K-generated N- and O-glycopeptides
J. Sep. Sci.
33
903-910
2010
Parengyodontium album
Pechkova, E.; Tripathi, S.; Ravelli, R.B.; McSweeney, S.; Nicolini, C.
Radiation stability of proteinase K crystals grown by LB nanotemplate method
J. Struct. Biol.
168
409-418
2009
Parengyodontium album (P06873)
Panek, J.J.; Mazzarello, R.; Novic, M.; Jezierska-Mazzarello, A.
Impact of mercury(II) on proteinase K catalytic center: investigations via classical and Born-Oppenheimer molecular dynamics
Mol. Divers.
15
215-226
2011
Parengyodontium album
Chatake, T.; Ishikawa, T.; Yanagisawa, Y.; Yamada, T.; Tanaka, I.; Fujiwara, S.; Morimoro, Y.
High-resolution X-ray study of the effects of deuteration on crystal growth and the crystal structure of proteinase K
Acta Crystallogr. Sect. F
67
1334-1338
2011
Parengyodontium album
Sommer, C.; Hertel, T.; Schmelzer, C.; Pietzsch, M.
Investigations on the activation of recombinant microbial pro-transglutaminase: in contrast to proteinase K, dispase removes the histidine-tag
Amino Acids
42
997-1006
2012
Parengyodontium album
Kore, A.R.; Shanmugasundaram, M.
Design, synthesis and inhibitory effect of pentapeptidyl chloromethyl ketones on proteinase K
Bioorg. Med. Chem.
18
8383-8387
2010
Homo sapiens
Tao, Y.; Rao, Z.; Liu, S.
Insight derived from molecular dynamics simulation into substrate-induced changes in protein motions of proteinase K
J. Biomol. Struct. Dyn.
28
143-157
2010
Parengyodontium album
Tiberti, M.; Papaleo, E.
Dynamic properties of extremophilic subtilisin-like serine-proteases
J. Struct. Biol.
174
69-83
2011
Parengyodontium album
Kore, A.; Shanmugasundaram, M.; Charles, I.
Synthesis and application of new rearranged tetrapeptidyl chloromethyl ketones as potent proteinase k inhibitor
Lett. Org. Chem.
8
33-37
2011
Homo sapiens
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Ageitos, J.M.; Baker, P.J.; Sugahara, M.; Numata, K.
Proteinase K-catalyzed synthesis of linear and star oligo(L-phenylalanine) conjugates
Biomacromolecules
14
3635-3642
2013
Parengyodontium album (P06873)
Kumar Shukla, S.; Rao, T.S.
Dispersal of Bap-mediated Staphylococcus aureus biofilm by proteinase K
J. Antibiot.
66
55-60
2013
Parengyodontium album
Villarreal, J.V.; Jungfer, C.; Obst, U.; Schwartz, T.
DNase I and proteinase K eliminate DNA from injured or dead bacteria but not from living bacteria in microbial reference systems and natural drinking water biofilms for subsequent molecular biology analyses
J. Microbiol. Methods
94
161-169
2013
Parengyodontium album (P06873)
Petrotchenko, E.V.; Serpa, J.J.; Hardie, D.B.; Berjanskii, M.; Suriyamongkol, B.P.; Wishart, D.S.; Borchers, C.H.
Use of proteinase K nonspecific digestion for selective and comprehensive identification of interpeptide cross-links: application to prion proteins
Mol. Cell. Proteomics
11
M111.013524
2012
Parengyodontium album (P06873)
Imamura, M.; Kato, N.; Okada, H.; Yoshioka, M.; Iwamaru, Y.; Shimizu, Y.; Mohri, S.; Yokoyama, T.; Murayama, Y.
Insect cell-derived cofactors become fully functional after proteinase K and heat treatment for high-fidelity amplification of glycosylphosphatidylinositol-anchored recombinant scrapie and BSE prion proteins
PLoS ONE
8
e82538
2013
Parengyodontium album (P06873)
Sajnani, G.; Requena, J.R.
Prions, proteinase K and infectivity
Prion
6
430-432
2012
Parengyodontium album (P06873)
Yazawa, K.; Sugahara, M.; Yutani, K.; Takehira, M.; Numata, K.
Derivatization of proteinase K with heavy atoms enhances its thermal stability
ACS Catal.
6
3036-3046
2016
Parengyodontium album (P06873)
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Gheczy, N.; Kuechler, A.; Walde, P.
Proteinase K activity determination with beta-galactosidase as sensitive macromolecular substrate
Anal. Biochem.
513
54-60
2016
Parengyodontium album (P06873)
Jikuzono, T.; Horikawa, A.; Ishikawa, T.; Hirokawa, M.; Sugitani, I.; Inui, T.; Ishibashi, O.
Proteinase K treatment improves RNA recovery from thyroid cells fixed with liquid-based cytology solution
BMC Res. Notes
11
822
2018
Parengyodontium album (P06873)
Tajima, T.; Ogawa, F.; Nakamura, S.; Hashimoto, M.; Omote, M.; Nishimura, H.
Proteinase K is an activator for the male-dependent spermiogenesis pathway in Caenorhabditis elegans Its application to pharmacological dissection of spermiogenesis
Genes Cells
24
244-258
2019
Parengyodontium album (P06873)
Gulmez, C.; Altinkaynak, C.; Oezdemir, N.; Atakisi, O.
Proteinase K hybrid nanoflowers (P-hNFs) as a novel nanobiocatalytic detergent additive
Int. J. Biol. Macromol.
119
803-810
2018
Parengyodontium album (P06873)
Hosseini-Koupaei, M.; Shareghi, B.; Saboury, A.A.; Davar, F.; Sirotkin, V.A.; Hosseini-Koupaei, M.H.; Enteshari, Z.
Catalytic activity, structure and stability of proteinase K in the presence of biosynthesized CuO nanoparticles
Int. J. Biol. Macromol.
122
732-744
2019
Parengyodontium album (P06873)
Hosseini-Koupaei, M.; Shareghi, B.; Saboury, A.A.; Davar, F.
Molecular investigation on the interaction of spermine with proteinase K by multispectroscopic techniques and molecular simulation studies
Int. J. Biol. Macromol.
94
406-414
2017
Parengyodontium album (P06873)
Sang, P.; Yang, Q.; Du, X.; Yang, N.; Yang, L.Q.; Ji, X.L.; Fu, Y.X.; Meng, Z.H.; Liu, S.Q.
Effect of the solvent temperatures on dynamics of serine protease proteinase K
Int.J. Mol. Sci.
17
254
2016
Parengyodontium album (P06873)
Hosseini-Koupaei, M.; Shareghi, B.; Saboury, A.; Davar, F.; Raisi, F.
The effect of spermidine on the structure, kinetics and stability of proteinase K spectroscopic and computational approaches
RSC Adv.
6
105476-105486
2016
Parengyodontium album (P06873)
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