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Ac-(beta-cyclohexyl)alanineYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-(beta-cyclohexyl)alanineYKK
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-
-
?
Ac-Ala-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + ?
-
-
-
?
Ac-Ala-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + ?
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-
-
?
Ac-alpha-aminobutyric acid-YKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-alpha-aminobutyric acid-YKK
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-
-
?
Ac-Arg-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Arg-Tyr-Lys-Lys
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-
-
?
Ac-AYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-AYKK
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-
-
?
Ac-AYKR 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-AYKR
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-
-
?
Ac-Cit-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Cit-Tyr-Lys-Lys 4-methylcoumarin
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this substrate is cleaved poorly
-
?
Ac-CYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-CYKK
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-
-
?
Ac-FYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-FYKK
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-
-
?
Ac-Leu-Lys-Arg-p-nitroanilide + H2O
?
-
-
-
?
Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Nle-Tyr-Lys-Arg-COOH
Ac-Nle-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + ?
-
-
-
?
Ac-Nle-YKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Nle-YKK
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-
-
?
Ac-Nle-YKR 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + ?
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-
-
?
Ac-Nle-YKR 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Nle-YKR
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-
-
?
Ac-norvaline-YKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-norvaline-YKK
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-
-
?
Ac-Pro-Met-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + ?
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-
-
?
Ac-Pro-Met-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Pro-Met-Tyr-Lys-Arg
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-
-
?
Ac-RYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-RYKK
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-
-
?
Ac-VYKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-VYKK
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?
alpha-mating factor + H2O
?
-
cleavage of dibasic sites
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?
Arg-Lys(DABCYL)-Nle-Tyr-Lys-Arg-Glu-Ala-Glu-Ala-Glu(EDANS)-Arg + H2O
Arg-Lys(DABCYL)-Nle-Tyr-Lys-Arg + Glu-Ala-Glu-Ala-Glu(EDANS)-Arg
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-
-
?
Arg-Lys(DABCYL)-Nle-Tyr-Lys-Lys-Glu-Ala-Glu-Ala-Glu(EDANS)-Arg + H2O
Arg-Lys(DABCYL)-Nle-Tyr-Lys-Lys + Glu-Ala-Glu-Ala-Glu(EDANS)-Arg
-
-
-
?
benzyloxycarbonyl-Ala-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + benzyloxycarbonyl-Ala-Tyr-Lys-Lys
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-
-
?
benzyloxycarbonyl-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
?
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-
-
?
benzyloxycarbonyl-Nle-Tyr-Lys-Lys 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Cbz-Nle-Tyr-Lys-Lys
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-
-
?
benzyloxycarbonyl-Nle-YKR 4-methylcoumarin 7-amide + H2O
?
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-
-
?
Benzyloxycarbonyl-Tyr-Lys-Arg 4-nitroanilide + H2O
?
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-
-
-
?
CLC chloride channel + H2O
proteolytically processed CLC chloride channel
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cleavage in first intracellular loop at residues K136/R137
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?
corin + H2O
?
-
activating processing of corin by enzyme PCSK6
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-
?
D-Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
?
-
-
-
?
Dpy-5 procollagen + H2O
?
-
-
-
-
?
Killer toxin precursors + H2O
?
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cleavage of dibasic sites
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-
?
L-pyroglutamyl-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide + H2O
L-pyroglutamyl-Arg-Thr-Lys-Arg + 7-amino-4-methyl-coumarin
-
-
-
-
?
low density lipoprotein receptor
?
-
-
-
?
low density lipoprotein receptor + H2O
?
low density lipoprotein receptor-related protein 1 + H2O
?
low-density lipoprotein receptor
?
PCSK9 posttranslationally promotes the degradation of the low-density lipoprotein receptor
-
-
?
N-tert-butyloxycarbonyl-Gly-Lys-Arg 4-methylcoumarin 7-amide + H2O
N-tert-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methylcoumarin
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59.2% of the activity with tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide
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?
pGlu-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide + H2O
7-amino-4-methylcoumarin
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-
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?
Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O
?
prekallikrein
?
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cleaved into four fragments by ASP, protein cleaved at specific sequences
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-
?
pro-alpha-mating factor + H2O
alpha-mating factor + ?
Proinsulin + H2O
Insulin + ?
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cleaves human proinsulin at the peptide bond between Arg32 and Glu33
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?
proopiomelanocortin + H2O
beta-lipotropic hormone + adrenocorticotropic hormone + ?
-
-
-
-
?
t-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumaryl-7-amide + H2O
t-butyloxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methyl-coumarin
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-
-
-
?
t-butyloxycarbonyl-EKK 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + t-butyloxycarbonyl-EKK
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-
-
?
t-butyloxycarbonyl-Glu-Lys-Lys-4-methylcoumaryl-7-amide + H2O
t-butyloxycarbonyl-Glu-Lys-Lys + 7-amino-4-methyl-coumarin
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best substrate
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-
?
t-butyloxycarbonyl-Gly-Lys-Arg-4-methylcoumaryl-7-amide + H2O
t-butyloxycarbonyl-Gly-Lys-Arg + 7-amino-4-methyl-coumarin
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-
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?
t-butyloxycarbonyl-QGR 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + t-butyloxycarbonyl-QGR
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-
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?
tert-Butyloxycarbonyl-Ala-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
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17% of the activity with tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide
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?
tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide + H2O
tert-butyloxycarbonyl-Gln-Arg-Arg + 7-amino-4-methylcoumarin
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-
-
-
?
tert-Butyloxycarbonyl-Leu-Arg-Arg 4-methylcoumarin 7-amide + H2O
?
-
116% of the activity with tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide
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-
?
tert-Butyloxycarbonyl-Leu-Lys-Arg 4-methylcoumarin 7-amide + H2O
?
-
92.8% of the activity with tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide
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-
?
tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
?
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38% of the activity with tert-butyloxycarbonyl-Gln-Arg-Arg 4-methylcoumarin 7-amide
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-
?
additional information
?
-
Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Nle-Tyr-Lys-Arg-COOH
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-
-
?
Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide + H2O
7-amino-4-methylcoumarin + Ac-Nle-Tyr-Lys-Arg-COOH
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-
-
?
low density lipoprotein receptor + H2O
?
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-
?
low density lipoprotein receptor + H2O
?
-
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-
?
low density lipoprotein receptor + H2O
?
degradation
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-
?
low density lipoprotein receptor + H2O
?
-
C-terminal domain of enzyme has a stronger affinity for substrate low density lipoprotein receptor than catalytic domain. A C-terminal deletion mutant does not mediate low density lipoprotein receptor degradation
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?
low density lipoprotein receptor + H2O
?
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PCSK9 binding to cell surface low density lipoprotein receptor cannot be described by a simple bimolecular reaction. Data suggest the presence of two populations of binding site
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-
?
low density lipoprotein receptor + H2O
?
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-
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?
low density lipoprotein receptor + H2O
?
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?
low density lipoprotein receptor + H2O
?
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a discrete C-terminal protein fragment competes with full-length PCSK9 for binding to LDLR in vitro and attenuates PCSK9-mediated hypercholesterolemia in mice
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
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degradation
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
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the enzyme acts on the extracellular domain of the receptor molecule
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
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degradation
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?
low density lipoprotein receptor-related protein 1 + H2O
?
degradation
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
-
the enzyme acts on the extracellular domain of the receptor molecule
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
degradation
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-
?
low density lipoprotein receptor-related protein 1 + H2O
?
the enzyme acts on the extracellular domain of the receptor molecule
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-
?
Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O
?
-
processing
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-
?
Precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae + H2O
?
-
processing
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-
?
pro-alpha-mating factor + H2O
alpha-mating factor + ?
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-
-
?
pro-alpha-mating factor + H2O
alpha-mating factor + ?
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-
-
?
pro-alpha-mating factor + H2O
alpha-mating factor + ?
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mating pheromone precursor, physiological substrate
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?
proGIP + H2O
GIP
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?
proGIP + H2O
GIP
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?
Protein + H2O
?
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?
Protein + H2O
?
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specificity: preference for Lys-Arg, while Arg-Arg, Pro-Arg, Ala-Arg, and Thr-Arg are equally rapidly cleaved but with higher Km
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-
?
Protein + H2O
?
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autocatalytic activation at an internal Lys108-Arg109
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-
?
Protein + H2O
?
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precursor protein of the mating hormone alpha-factor of Saccharomyces cerevisiae
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-
?
Protein + H2O
?
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specificity towards the carbonyl side of Lys-Arg, Arg-Arg and Pro-Arg sequences
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?
Protein + H2O
?
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cleaves a wide variety of precursors from higher eukaryotes including prohormones, such as proinsulin and proopiomelanocortin, as well as precursors of constitutively secreteted proteins, such as proalbumin
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-
?
Protein + H2O
?
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-
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-
?
additional information
?
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FRETS-25Xaa libraries as substrates. Best FRETS contains Lys at position Xaa (FRETS-25K). No cleavage of succinyl-Ala-Ala-Pro-Phe-4-methylylcoumaryl-7-amide, t-butyloxycarbonyl-Gly-Arg-Arg-4-methylylcoumaryl-7-amide, Z-His-Glu-Lys-4-methylylcoumaryl-7-amide, and t-butyloxycarbonyl-Phe-Ser-Arg-4-methylylcoumaryl-7-amide
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-
?
additional information
?
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both furinand hepsin-cleaved enzymes are able to degrade LDL receptor on HepG2 cells resulting in elevated serum cholesterol levels
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-
?
additional information
?
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the enzyme catalytic domain is capable of proteolysis in trans (i.e. as two separate polypeptides), and can perform intermolecular proteolysis
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-
?
additional information
?
-
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CT-peptide is not cleaved by enzymatically active PC1/3
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?
additional information
?
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a variety of trypsin substrates containing only one basic amino acid
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?
additional information
?
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cleaves peptide substrates at both Lys-Arg and Arg-Arg sites, not: benzyloxycarbonyl-Lys-Arg 4-nitroanilide, benzyloxycarbonyl-Arg-Arg 4-nitroanilide
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-
?
additional information
?
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exhibits optimal activity toward substrates with Lys or Arg at P2 and Arg at P1, also recognizes P4, with dual specificity for aliphatic and basic residues
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?
additional information
?
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generates peptide hormone by specific processing of propeptides
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?
additional information
?
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hydrolyzes peptides and proteins with basic amino acid pairs which are cleaved at the C-ends of their peptide bonds, cleaves specifically large recombinant proteins, for example a protein consisting of a gamma-interferon fragment linked to HIV1-proteinase via a Lys-Arg-containing peptide
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?
additional information
?
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carries out specific endoproteolytic cleavage of proprotein and prohormone precursors in the secretory pathway, hydrolyzes ester and amide substrates
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?
additional information
?
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transforming the precursors of biologically active agents into their functional forms, processing and conversion of prohormones
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?
additional information
?
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wild-type, preference for positively charged residues at P2 position. Mutant D176G/D210A/D211S, preference for MR- over LR- or FR-containing substrates, which cannot be cleaved by wild-type
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-
?
additional information
?
-
-
a variety of trypsin substrates containing only one basic amino acid
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-
?
additional information
?
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cleaves peptide substrates at both Lys-Arg and Arg-Arg sites, not: benzyloxycarbonyl-Lys-Arg 4-nitroanilide, benzyloxycarbonyl-Arg-Arg 4-nitroanilide
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-
?