3.4.21.61: Kexin

This is an abbreviated version!
For detailed information about Kexin, go to the full flat file.

Word Map on EC 3.4.21.61

3.4.21.61

cholesterol

lipoprotein

cardiovascular

low-density

statin

hypercholesterolemia

coronary

lipid-lowering

atherosclerotic

ezetimibe

evolocumab

alirocumab

furin

artery

apolipoprotein

triglyceride

ldl-cholesterol

dyslipidemias

myocardial

placebo

stroke

high-risk

ascvd

infarction

atherogenic

hyperlipidemia

atorvastatin

cholesterol-lowering

intolerance

lipoprotein-cholesterol

hdl

cardiology

apheresis

diagnostics

non-high-density

ldl-receptors

angiopoietin-like

proinsulin

proopiomelanocortin

treatment-emergent

srebp-2

endoproteolytic

guideline-recommended

triglyceride-rich

drug development

prodomain

endoproteases

degradation

non-hdl-c

fibrates

xanthoma

statin-treated

molecular biology

medicine

niacin

Reaction

Cleavage of -Lys-Arg-/- and -Arg-Arg-/- bonds to process yeast alpha-factor pheromone and killer toxin precursors =

Synonyms

adrenorphin-Gly-generating enzyme, ASP, BLI-4, corin activating enzyme, EC 3.4.22.23, endoproteinase Kex2p, Gene KEX2 dibasic proteinase, HuPCSK6, Kex 2p proteinase, Kex2, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, Kex2 proteinase, Kex2-660, Kex2-like endoproteinase, Kex2-like precursor protein processing endoprotease, Kex2p, kexin, More, NARC-1, Paired-basic endopeptidase, PC 1/3, PC1, PC1/3, PC2, PCSK type 9, PCSK6, PCSK9, plasma proprotein convertase subtilisin-kexin type 9, pro-protein convertase subtilisin/kexin type 9, prohormone convertase 1, prohormone convertase 1/3, prohormone convertase 2, prohormone processing protease, Prohormone-processing endoprotease, Prohormone-processing KEX2 proteinase, Prohormone-processing proteinase, Proprotein convertase, proprotein convertase 1/3, proprotein convertase Kex2, proprotein convertase subtilisin kexin type 9, proprotein convertase subtilisin kexin-9, proprotein convertase subtilisin-like/kexin type 9, proprotein convertase subtilisin/kexin 6, proprotein convertase subtilisin/kexin type 6, proprotein convertase subtilisin/kexin type 9, proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9, proprotein processing protease, Protease KEX2, Proteinase Kex2p, Proteinase yscF, Proteinase, prohormone-processing, Yeast KEX2 protease

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.61 Kexin

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Results	in table
10	Activating Compound
23	AA Sequence
24	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Crystallization (Commentary)
9474	Disease/ Diagnostics
9	Expression
31	General Information
6	IC50 Value
73	Inhibitors
14	Ki Value [mM]
9	KM Value [mM]
24	Localization
10	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
209	Organism
10	PDB ID
6	pH Optimum
1	pH Range
10	pH Stability
5	Posttranslational Modification
60	Protein Variants
18	Purification (Commentary)
2	Reaction
1	Reaction Type
70	Reference
71	Source Tissue
2	Storage Stability
108	Substrates and Products (Substrate)
4	Subunits
120	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.21.61 - Kexin

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O13359 pBLAST

KEX2_CANAW

Candida albicans (strain WO-1)

938

105144

Swiss-Prot