3.4.21.59: Tryptase

This is an abbreviated version!
For detailed information about Tryptase, go to the full flat file.

Word Map on EC 3.4.21.59

3.4.21.59

histamine

allergic

chymase

anaphylaxis

degranulation

eosinophil

mastocytosis

ige

granule

airway

asthma

marrow

mucosal

anaphylactic

nasal

c-kit

basophil

lavage

par-2

rhinitis

bronchial

asthmatic

urticaria

atopic

leukotriene

toluidine

sting

hymenoptera

trypsin-like

receptor-2

provocation

ige-mediated

prick

anti-ige

metachromatic

proteinase-activated

mast-cell

antihistamine

sneezing

nonallergic

ige-dependent

angioedema

bronchospasm

pruritus

drug development

wheal

nonatopic

ketotifen

nafamostat

cladribine

enzyme-histochemical

medicine

Reaction

Preferential cleavage: Arg-/-, Lys-/-, but with additional information restricted specificity than trypsin =

Synonyms

alpha 1-tryptase, alpha tryptase, alpha-tryptase, basal serum tryptase, beta tryptase I, beta tryptase II, beta-tryptase, betaI-tryptase, betaII-tryptase, BLCT, bovine liver capsule tryptase, bovine mast cell tryptase, BTM, delta-tryptase, gamma-tryptase, group 2 tryptase, HAST, HMC-1 tryptase, HTbeta, human beta-tryptase, human betaII-tryptase, human lung tryptase, human mast cell tryptase, human mast cell tryptase beta I, human tryptase alpha, human tryptase beta, human tryptase beta/2, human tryptase-beta, Lung tryptase, Mast cell neutral proteinase, mast cell protease 11, mast cell protease 6, mast cell protease 7, Mast cell protease II, mast cell protease-6, Mast cell proteinase II, mast cell specific tryptase, Mast cell tryptase, mast cell tryptase beta, mast cell-derived tryptase, mast cell-specific protease, mast cell-specific tryptase, MC protease 6, MC protease 7, MC protease-6, MC tryptase, MCP-11, MCP-6, MCP-7, Mcpt6, MCT, mMCP-6, mouse mast cell protease 6, mouse mast cell protease-6, Pituitary tryptase, Proteinase, mast cell neutral, Proteinase, mast cell serine, II, Proteinase, mast cell serine, tryptase, Prss31, Rat mast cell protease II, rHT, S-tryptase, sBT, serine protease tryptase, serum baseline tryptase, serum mast cell tryptase, serum tryptase, Skin tryptase, TMT, TPSAB1, TPSB2, transmembrane tryptase, tryptase, tryptase alpha, tryptase alpha-1, tryptase beta, tryptase beta-1, tryptase beta-2, Tryptase M, Tryptase, skin, tryptase-2, tryptase-beta, tryptase-beta1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.59 Tryptase

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Results	in table
5	Activating Compound
22	AA Sequence
24	Application
1	CAS Registry Number
31	Cloned(Commentary)
8	Crystallization (Commentary)
6216	Disease/ Diagnostics
14	Expression
20	General Information
28	General Stability
20	IC50 Value
346	Inhibitors
5	kcat/KM [mM/s]
149	Ki Value [mM]
93	KM Value [mM]
43	Localization
1	Metals/Ions
46	Molecular Weight [Da]
56	Natural Substrates/ Products (Substrates)
160	Organism
79	PDB ID
12	pH Optimum
4	pH Range
2	pH Stability
3	pI Value
9	Posttranslational Modification
18	Protein Variants
43	Purification (Commentary)
1	Reaction
1	Reaction Type
157	Reference
1	Renatured (Commentary)
154	Source Tissue
7	Specific Activity [micromol/min/mg]
6	Storage Stability
207	Substrates and Products (Substrate)
55	Subunits
213	Synonyms
6	Temperature Optimum [°C]
7	Temperature Stability [°C]
111	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.59 - Tryptase

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100000

Homo sapiens

enzyme-antithrombin III complex, gel filtration

683545

110000

Homo sapiens

human, gel filtration in presence of 0.3 M NaCl

120000

132000

134000

135000 - 144000

human

140000

Canis lupus familiaris

dog, gel filtration

29382

144000

Canis lupus familiaris

dog

145000

rat, gel filtration

145000 - 160000

rat mast cell enzyme

147000

enzyme in complex with murine B12 Fab, gel filtration

150000

16000 - 120000

gel filtration

200000

29000

x * 29000 + x * 33000, human, SDS-PAGE

29000 - 40000

immunoreaction

30000

4 * 30000, rHTalpha, mutant D216G, SDS-PAGE, recombinant rHTbeta

650140

30000 - 37000

Homo sapiens

Western blotting with monoclonal antibody AA5

31000

32000

33000

34000

35000

360000

38000

x * 34000 + x * 38000, human, SDS-PAGE

29373

39000

Bos taurus

x * 39000 + x * 40000, SDS-PAGE of DFP-labelled enzyme

29393

40000

Bos taurus

x * 39000 + x * 40000, SDS-PAGE of DFP-labelled enzyme

29393

additional information

Rattus norvegicus

MW of the complex of tryptase and trypstatin: 144000, rat, gel filtration, MW of trypstatin is 7600 on gel filtration

29374