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3.4.21.59: Tryptase

This is an abbreviated version!
For detailed information about Tryptase, go to the full flat file.

Word Map on EC 3.4.21.59

Reaction

Preferential cleavage: Arg-/-, Lys-/-, but with additional information restricted specificity than trypsin =

Synonyms

alpha 1-tryptase, alpha tryptase, alpha-tryptase, basal serum tryptase, beta tryptase I, beta tryptase II, beta-tryptase, betaI-tryptase, betaII-tryptase, BLCT, bovine liver capsule tryptase, bovine mast cell tryptase, BTM, delta-tryptase, gamma-tryptase, group 2 tryptase, HAST, HMC-1 tryptase, HTbeta, human beta-tryptase, human betaII-tryptase, human lung tryptase, human mast cell tryptase, human mast cell tryptase beta I, human tryptase alpha, human tryptase beta, human tryptase beta/2, human tryptase-beta, Lung tryptase, Mast cell neutral proteinase, mast cell protease 11, mast cell protease 6, mast cell protease 7, Mast cell protease II, mast cell protease-6, Mast cell proteinase II, mast cell specific tryptase, Mast cell tryptase, mast cell tryptase beta, mast cell-derived tryptase, mast cell-specific protease, mast cell-specific tryptase, MC protease 6, MC protease 7, MC protease-6, MC tryptase, MCP-11, MCP-6, MCP-7, Mcpt6, MCT, mMCP-6, mouse mast cell protease 6, mouse mast cell protease-6, Pituitary tryptase, Proteinase, mast cell neutral, Proteinase, mast cell serine, II, Proteinase, mast cell serine, tryptase, Prss31, Rat mast cell protease II, rHT, S-tryptase, sBT, serine protease tryptase, serum baseline tryptase, serum mast cell tryptase, serum tryptase, Skin tryptase, TMT, TPSAB1, TPSB2, transmembrane tryptase, tryptase, tryptase alpha, tryptase alpha-1, tryptase beta, tryptase beta-1, tryptase beta-2, Tryptase M, Tryptase, skin, tryptase-2, tryptase-beta, tryptase-beta1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.59 Tryptase

Expression

Expression on EC 3.4.21.59 - Tryptase

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
elevated postmortem mast cell tryptase level indicate anaphylaxis
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elevated tryptase levels are found to cluster in patients with myeloid neoplasms, including chronic myeloid leukaemia, chronic myelomonocytic leukaemia, myelodysplastic syndromes, acute myeloid leukaemia, and mastocytosis
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Hymenoptera venom immunotherapy is associated with a small, but continuous decrease of baseline serum mast cell tryptase concentration over time
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increased tryptase is associated with higher tumor grade and more lymph node metastasis in breast cancer tissue
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mast cell tryptase level is significantly lower in pregnant women with preeclampsia and healthy pregnant women than in healthy non-pregnant women
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mast cells from IL1RL1-null mice exhibit a marked reduction in MCP-6 expression
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mast cells lacking IL1RL1 exhibit defective fibroblast-driven tryptase accumulation
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microphthalmia-associated transcription factor plays a role in regulating the transcription of tryptase gene in human mast cells
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morphometric analysis shows a significantly higher positivity for tryptase in the cords of liveborn fetuses than in those of stillborn fetuses
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serum tryptase levels are positively associated with beekeeping activities, Hymenoptera venom allergy, age, and male sex
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significantly higher concentrations of tryptase are found in peripheral blood of sarcoidosis patients than controls, patients with progressive disease show the highest tryptase concentrations in serum
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the transcriptional activity of tryptase gene is specifically higher in HMC-1 cells compared to the tryptase-negative cells
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tryptase (MCP-6 and MCP-7) expression and activity are increased during progression of skin tumors in mice
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tryptase levels are higher in individuals that are non-atopic, overweight, or have metabolic syndrome compared to individuals that are atopic, normal weight, or do not have the metabolic syndrome, however, these associations are attenuated after adjusting for age
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