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3.4.21.59: Tryptase

This is an abbreviated version!
For detailed information about Tryptase, go to the full flat file.

Word Map on EC 3.4.21.59

Reaction

Preferential cleavage: Arg-/-, Lys-/-, but with additional information restricted specificity than trypsin =

Synonyms

alpha 1-tryptase, alpha tryptase, alpha-tryptase, basal serum tryptase, beta tryptase I, beta tryptase II, beta-tryptase, betaI-tryptase, betaII-tryptase, BLCT, bovine liver capsule tryptase, bovine mast cell tryptase, BTM, delta-tryptase, gamma-tryptase, group 2 tryptase, HAST, HMC-1 tryptase, HTbeta, human beta-tryptase, human betaII-tryptase, human lung tryptase, human mast cell tryptase, human mast cell tryptase beta I, human tryptase alpha, human tryptase beta, human tryptase beta/2, human tryptase-beta, Lung tryptase, Mast cell neutral proteinase, mast cell protease 11, mast cell protease 6, mast cell protease 7, Mast cell protease II, mast cell protease-6, Mast cell proteinase II, mast cell specific tryptase, Mast cell tryptase, mast cell tryptase beta, mast cell-derived tryptase, mast cell-specific protease, mast cell-specific tryptase, MC protease 6, MC protease 7, MC protease-6, MC tryptase, MCP-11, MCP-6, MCP-7, Mcpt6, MCT, mMCP-6, mouse mast cell protease 6, mouse mast cell protease-6, Pituitary tryptase, Proteinase, mast cell neutral, Proteinase, mast cell serine, II, Proteinase, mast cell serine, tryptase, Prss31, Rat mast cell protease II, rHT, S-tryptase, sBT, serine protease tryptase, serum baseline tryptase, serum mast cell tryptase, serum tryptase, Skin tryptase, TMT, TPSAB1, TPSB2, transmembrane tryptase, tryptase, tryptase alpha, tryptase alpha-1, tryptase beta, tryptase beta-1, tryptase beta-2, Tryptase M, Tryptase, skin, tryptase-2, tryptase-beta, tryptase-beta1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.59 Tryptase

Cloned

Cloned on EC 3.4.21.59 - Tryptase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cDNA cloned and expressed in the methylotrophic yeast Pichia pastoris as protryptase
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commercial preparation
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expressed in baculovirus-infected Trichoplusia ni insect cells
expressed in Pichia pastoris
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expressed in Pichia pastoris yeast system pPICZa
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expression of alphaI-tryptase mutants in insect cells
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expression of gamma-tryptase as either a soluble, single-chian enzyme with a C-terminal His tag or as a soluble pseudozymogen activated by enterokinase cleavage to form a two-chain protein with an N-terminal His tag. Both recombinant proteins are expressed at high levels in Pichia pastoris
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expression pattern and sequence comparisons of isozymes, overview
gene mtc1, DNA and amino acid sequence determination and analysis, equine tryptase has alanine at residue 216, rather than glycine, which confers increased arginine substrate specificity in vitro and may restrict fibrinogenolysis in vivo
genetic localization
human mast cell tryptases are the products of a multigene family
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lung beta-tryptase, commercial preparation
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recombinant tryptase expressed in human 293 cells
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skin beta-tryptase, commercial preparation
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tryptases alpha and beta/II cDNA cloned and expressed in baculovirus-infected high five TM insect cells
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tryptases betaI and betaII heterolougously expressed in the yeast Pichia pastoris
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version with Flag peptide and enterokinase-cleavage site expressed in Sf9 insect cells
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