3.4.21.57: Leucyl endopeptidase

This is an abbreviated version, for detailed information about Leucyl endopeptidase, go to the full flat file.

Reaction

Hydrolysis of proteins. Preferential cleavage: Leu-/- in small molecule substrates =

Synonyms

Leu-proteinase, Leucine endopeptidase, Leucine-specific serine proteinase, Plant Leu-proteinase, Proteinase, leucine-specific, Proteinase, spinach serine (leucine specific), Spinach leucine-specific serine proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.57 Leucyl endopeptidase

Turnover Number

Turnover Number on EC 3.4.21.57 - Leucyl endopeptidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.1
Nalpha-benzoyl-Arg 4-nitroanilide
-
-
1.2
Nalpha-benzoyl-Gly 4-nitroanilide
-
-
4.9
Nalpha-benzoyl-L-Ala 4-nitroanilide
-
-
1.8
Nalpha-benzoyl-L-Lys 4-nitroanilide
-
-
21.3
Nalpha-benzoyl-Leu 4-nitroanilide
-
-
6.1
Nalpha-benzoyl-Val 4-nitroanilide
-
-
94
Nalpha-carbobenzoxy-Ala 4-nitrophenyl ester
-
-
43
Nalpha-carbobenzoxy-Arg 4-nitrophenyl ester
-
-
21
Nalpha-carbobenzoxy-Gly 4-nitrophenyl ester
-
-
140
Nalpha-carbobenzoxy-Ile 4-nitrophenyl ester
-
-
430
Nalpha-carbobenzoxy-Leu 4-nitrophenyl ester
-
-
45
Nalpha-carbobenzoxy-Lys 4-nitrophenyl ester
-
-
140
Nalpha-carbobenzoxy-Val 4-nitrophenyl ester
-
-
additional information
additional information
-
the acylation step is the rate-limiting in catalysis
-