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3.4.21.47: alternative-complement-pathway C3/C5 convertase

This is an abbreviated version!
For detailed information about alternative-complement-pathway C3/C5 convertase, go to the full flat file.

Word Map on EC 3.4.21.47

Reaction

Cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to yield C5a and C5b =

Synonyms

(C3b)n,Bb, (CVF)-dependent glycine-rich-beta-glucoprotein, alternative C3 convertase, alternative C5 convertase, alternative complement pathway C3 convertase, alternative complement pathway C3(C5) convertase, alternative pathway C3 convertase, alternative pathway C3 convertase complex, alternative pathway C3-convertase, alternative pathway C3/C5 convertase, alternative pathway C5 convertase, alternative pathway of complement C3/C5 convertase, alternative-complement-pathway C3/C5 convertase, AP C3 convertase, AP C3-convertase, AP C3/C5 convertase, AP C5 convertase, APC C3/C5 convertase, C3 convertase, C3 proactivator, C3/C5 convertase, C3b,Bb, C3b2, C3bB complex, C3bBb, C3bBb convertase, C3bBb(C3b)n, C3bBb3b, C3bBbC3b, C5 convertase, cobra venom factor-dependent C3 convertase, complement alternative pathway C3 convertase, complement C 3(C 5) convertase (amplification), complement C5 convertase, complement component C3/C5 convertase (alternative), convertase, complement C3(C5) (amplification), CVF,Bb, CVFh,Bb, CVFn,Bb, GBG, Glycine-rich beta glycoprotein, heat-labile factor, PBF2, proenzyme factor B, properdin factor B

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.47 alternative-complement-pathway C3/C5 convertase

General Stability

General Stability on EC 3.4.21.47 - alternative-complement-pathway C3/C5 convertase

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
marked stabilization of enzyme by naturally occuring IgG directed against the enzyme. Antibody prevents convertase decay in the presence of factor H. In addition, the antibody stabilizes enzyme precursors and promotes enzyme assembly
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properdin stabilizes enzyme-IgG complexes before any other complement protein has bound to them. The alternative pathway of convertase generation may depend on whether properdin is bound to its precursor, a C3b or a C3b2-IgG complex
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the C3 convertase is stabilized by the binding of properdin
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the enzyme has a very short half-life. Dissociation of the two noncovalently bound subunits proceeds with a half-life of 1-3 min at 37°C under physiological conditions, and this rate increases greatly if regulatory proteins are present. Numerous decay-accelerating proteins are present in plasma and on host cells that bind to the noncatalytic subunit C3b and increase the rate at which the catalytic subunit Bb is released into the medium. Bb loses its enzymatic activity and its ability to bind to C3b upon release. Although C3b is able to rebind Bb and reform the enzyme, the interaction with most decay-accelerating factors also leads to permanent proteolytic interaction of the cell-bound subunit C3b by a fluid-phase protease Factor I. These regulatory events limit cleavage of C3, reduce release of the anaphylatoxin C3a and control the formation of more efficient C5 convertase enzymes
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the enzyme is subject to irreversible dissociation by three proteins: DAF, CR1 and factor H
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